Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Deniz Kent"'
Autor:
Joe M. Segal, Deniz Kent, Daniel J. Wesche, Soon Seng Ng, Maria Serra, Bénédicte Oulès, Gozde Kar, Guy Emerton, Samuel J. I. Blackford, Spyros Darmanis, Rosa Miquel, Tu Vinh Luong, Ryo Yamamoto, Andrew Bonham, Wayel Jassem, Nigel Heaton, Alessandra Vigilante, Aileen King, Rocio Sancho, Sarah Teichmann, Stephen R. Quake, Hiromitsu Nakauchi, S. Tamir Rashid
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
The liver parenchyma consists of several cell types, but the origin of this tissue in humans is unclear. Here, the authors perform single cell RNA sequencing of human fetal and adult liver to identify a hepatobiliary hybrid progenitor population of c
Externí odkaz:
https://doaj.org/article/6bbc0c0ed8f149fd9701e5f07676f1d3
Autor:
Deniz Kent, Soon Seng Ng, Payam Khoshkenar, Adam Syanda, Chao Zheng Li, Marina Zieger, Stephanie Hatch, Joe Segal, Samuel Blackford, Kaixing Le, Vivek Chowdary, Taylor Ismaili, Davide Danovi, Patrick Lewis, Sunil Sahdeo, Daniel Ebner, Christian Mueller, S. Tamir Rashid
Alpha-1 antitrypsin deficiency (A1ATD) is a life-threatening condition caused by inheritance of the SERPINA1-Z genetic variant (PiZ) leading to protein misfolding and liver toxicity. There remain no approved medicines for this disease. Here we report
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fb8daaf1f53f7f2962db34f88649f13a
https://doi.org/10.21203/rs.3.rs-1283764/v1
https://doi.org/10.21203/rs.3.rs-1283764/v1
Autor:
Ryo Yamamoto, Rosa Miquel, Rocio Sancho, Andrew Bonham, Wayel Jassem, Stephen R. Quake, Spyros Darmanis, Deniz Kent, Bénédicte Oulès, Maria Paola Serra, Joe M. Segal, Sarah A. Teichmann, Hiromitsu Nakauchi, Guy Emerton, S. Tamir Rashid, Alessandra Vigilante, Aileen King, Samuel J.I. Blackford, Soon Seng Ng, Gozde Kar, Nigel Heaton, Daniel J. Wesche, Tu Vinh Luong
Publikováno v:
Segal, J M, Kent, D H, Wesche, D, Ng, S S, Quake, S, Serra, M, Nakauchi, H, Rashid, S T, King, A, Oules, B, Kar, G, Emerton, G, Blackford, S, Darmanis, S, Miquel, R, Luong, T V, Yamamoto, R, Bonham, A, Jassem, W, Heaton, N, Vigilante, A, Sancho, R & Teichmann, S A 2019, ' Single cell analysis of human foetal liver captures the transcriptional profile of hepatobiliary hybrid progenitors ', Nature Communications, vol. 10, no. 1, 3350 . https://doi.org/10.1038/s41467-019-11266-x
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Nature Communications
The liver parenchyma is composed of hepatocytes and bile duct epithelial cells (BECs). Controversy exists regarding the cellular origin of human liver parenchymal tissue generation during embryonic development, homeostasis or repair. Here we report t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ca01778b6f9524ce9dc061cb4df0234
https://kclpure.kcl.ac.uk/ws/files/112627999/NCOMMS_Final.pdf
https://kclpure.kcl.ac.uk/ws/files/112627999/NCOMMS_Final.pdf
Autor:
Samuel J I, Blackford, Soon Seng, Ng, Joe M, Segal, Aileen J F, King, Amazon L, Austin, Deniz, Kent, Jennifer, Moore, Michael, Sheldon, Dusko, Ilic, Anil, Dhawan, Ragai R, Mitry, S Tamir, Rashid
Publikováno v:
Stem Cells Translational Medicine
Recent advancements in the production of hepatocytes from human pluripotent stem cells (hPSC‐Heps) afford tremendous possibilities for treatment of patients with liver disease. Validated current good manufacturing practice (cGMP) lines are an essen
Autor:
Joe M. Segal, Deniz Kent, Hiromitsu Nakauchi, Gozde Kar, Tu Vinh, S. Tamir Rashid, Alessandra Vigilante, Samuel J.I. Blackford, Guy Emerton, Bénédicte Oulès, Ryo Yamamoto, Spyros Darmanis, Andrew Bonham, Maria Paola Serra, Daniel J. Wesche, Stephen R. Quake, Rosa Miquel, Soon Seng Ng, Sarah A. Teichmann
The liver is largely composed of hepatocytes and bile duct epithelial cells (BECs). Controversy exists as to whether a liver stem/progenitor cell capable of renewing both hepatocytes and BECs exists. Single cell RNA sequencing of freshly isolated hum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d6b89481ebb38efb3fb460a1d579bad