Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Deniz Baycin, Hizal"'
Autor:
Jahir M. Gutierrez, Amir Feizi, Shangzhong Li, Thomas B. Kallehauge, Hooman Hefzi, Lise M. Grav, Daniel Ley, Deniz Baycin Hizal, Michael J. Betenbaugh, Bjorn Voldborg, Helene Faustrup Kildegaard, Gyun Min Lee, Bernhard O. Palsson, Jens Nielsen, Nathan E. Lewis
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
The secretory pathway is used in the production of most biopharmaceuticals, but the associated biosynthetic costs are little understood. Here, the authors integrate the core secretory pathway into genome-scale metabolic models of human, mouse, and CH
Externí odkaz:
https://doaj.org/article/7b7b5cdd06f3404dbb201e1d925f5e77
Autor:
Nathan E. Lewis, Michael A. Bowen, Paula Meleady, Seong Won Cha, Shangzhong Li, Deniz Baycin Hizal, Susan T. Sharfstein, Prashant Kaushik, Vijay Tejwani, Robert N. Cole, Michael J. Betenbaugh, Kelley M. Heffner, Michael Henry, Raghothama Chaerkady, Vineet Bafna
Publikováno v:
J Proteome Res
A high quality genome annotation greatly facilitates successful cell line engineering. Standard draft genome annotation pipelines are based largely onde novogene prediction, homology, and RNA-Seq data. However, draft annotations can suffer from incor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::530ec4e0c70812cf31344fba75aa1e61
https://doi.org/10.1021/acs.jproteome.8b00935
https://doi.org/10.1021/acs.jproteome.8b00935
Autor:
Ayça Erşen Danyeli, Ege Ülgen, Pınar Kuru Bektaşoğlu, Deniz Baycin Hizal, M. Necmettin Pamir, Koray Özduman, M. Aydın Sav, Özge Can
Publikováno v:
World Neurosurgery. 123:e520-e535
Background Meningiomas are heterogeneous, with differences in anatomical, histopathological, and clinical characteristics. Such spatial variability in meningioma biology is thought to result from differences in the expression of critical developmenta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0b68a42f960ff243be2ce3ffd583677
https://doi.org/10.1016/j.wneu.2018.11.201
https://doi.org/10.1016/j.wneu.2018.11.201
Autor:
Miao Wang, Xianlin Han, Joseph Priola, Kelley M. Heffner, Yue Zhang, Deniz Baycin-Hizal, Michelle Bahri, Amit Kumar, Michael J. Betenbaugh, Michael A. Bowen
Publikováno v:
Analytical Chemistry. 89:1477-1485
A combined lipidomics and transcriptomics analysis was performed on mouse myeloma SP2/0, Chinese hamster ovary (CHO), and human embryonic kidney (HEK) cells in order to compare widely used mammalian expression systems. Initial thin layer chromatograp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a8b31d2b7373ae39544c07a5a9ce33b
https://doi.org/10.1021/acs.analchem.6b02984
https://doi.org/10.1021/acs.analchem.6b02984
Autor:
Athena Yerganian, Robert N. O'Meally, Michael A. Bowen, Venkata Gayatri Dhara, Kelley M. Heffner, Swetha Kumar, Natalia I. Majewska, Robert Cole, George Yerganian, Michael J. Betenbaugh, Deniz Baycin Hizal, Diane Hatton, Jie Zhu
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
Chinese hamster ovary (CHO) cells are the predominant production vehicle for biotherapeutics. Quantitative proteomics data were obtained from two CHO cell lines (CHO-S and CHO DG44) and compared with seven Chinese hamster (Cricetulus griseus) tissues
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa7911ff1513b39ed6a431d76914b64e
https://pubmed.ncbi.nlm.nih.gov/32985598
https://pubmed.ncbi.nlm.nih.gov/32985598
Autor:
Yuri A. Mirokhin, Dmitrii V. Tchekhovskoi, Sanford P. Markey, Jeri Roth, Deniz Baycin Hizal, Zheng Zhang, Xiaoyu Yang, Michael A. Bowen, Stephen E. Stein, Weihua Ji, Pedatsur Neta
Publikováno v:
Journal of Proteome Research. 15:3180-3187
Derivitization of peptides with isobaric tags such as iTRAQ and TMT is widely employed in proteomics due to their compatibility with multiplex quantitative measurements. We recently made publicly available a large peptide library derived from iTRAQ 4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4929a909ad7a315fc26c5f0a6ee6ba4
https://doi.org/10.1021/acs.jproteome.6b00406
https://doi.org/10.1021/acs.jproteome.6b00406
Publikováno v:
Advances in biochemical engineering/biotechnology. 175
Mammalian expression systems such as Chinese hamster ovary (CHO), mouse myeloma (NS0), and human embryonic kidney (HEK) cells serve a critical role in the biotechnology industry as the production host of choice for recombinant protein therapeutics. M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e4498df4d12aad15d7212504df2caca8
https://pubmed.ncbi.nlm.nih.gov/29532110
https://pubmed.ncbi.nlm.nih.gov/29532110
Publikováno v:
Advances in Glycobiotechnology ISBN: 9783030695897
Mammalian expression systems such as Chinese hamster ovary (CHO), mouse myeloma (NS0), and human embryonic kidney (HEK) cells serve a critical role in the biotechnology industry as the production host of choice for recombinant protein therapeutics. M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::19ff015273ed7333c00289110c38eb3f
https://doi.org/10.1007/10_2017_57
https://doi.org/10.1007/10_2017_57
Autor:
Michael J. Betenbaugh, Nathan E. Lewis, Michael A. Bowen, Deniz Baycin-Hizal, Raghothama Chaerkady, Amit Kumar, Daniel Wolozny, Kelley M. Heffner, Joseph Shiloach, Lasse Ebdrup Pedersen, Robert N. Cole, Hui Zhang
Publikováno v:
Journal of Proteome Research. 14:4687-4703
Chinese hamster ovary (CHO) cells are the preferred host cell line for manufacturing a variety of complex biotherapeutic drugs including monoclonal antibodies. We performed a proteomics and bioinformatics analysis on the spent medium from adherent CH
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b07a66597f91c417bb5d3d798f8ba687
https://doi.org/10.1021/acs.jproteome.5b00588
https://doi.org/10.1021/acs.jproteome.5b00588
Autor:
Dietmar Weilguny, Christian Müller, Anne Mathilde Lund, Jette Wagtberg Sen, Cleo Kontoravdi, Søren Kofoed Rasmussen, Yuzhou Fan, Ioscani Jimenez del Val, Michael J. Betenbaugh, Mikael Rørdam Andersen, Deniz Baycin-Hizal
Publikováno v:
Biotechnology and Bioengineering. 112:2172-2184
In this study, omics-based analysis tools were used to explore the effect of glucose starvation and culture duration on monoclonal antibody (mAb) production in fed-batch CHO cell culture to gain better insight into how these parameters can be control
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cf3ff5f631ee5d6f7a7ba698974c7826
https://doi.org/10.1002/bit.25620
https://doi.org/10.1002/bit.25620