Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Deniz B Temel"'
Autor:
Loren E Hough, Kaushik Dutta, Samuel Sparks, Deniz B Temel, Alia Kamal, Jaclyn Tetenbaum-Novatt, Michael P Rout, David Cowburn
Publikováno v:
eLife, Vol 4 (2015)
Nuclear pore complexes (NPCs) form a selective filter that allows the rapid passage of transport factors (TFs) and their cargoes across the nuclear envelope, while blocking the passage of other macromolecules. Intrinsically disordered proteins (IDPs)
Externí odkaz:
https://doaj.org/article/4ededb97a7ec4287865fadfd89ee7512
Autor:
Noi Nuanmanee, Mike Treuheit, Deniz B. Temel, Wei Qi, Victoria Jann, Vladimir I. Razinkov, Larysa Alekseychyk
Publikováno v:
Journal of Pharmaceutical Sciences. 110:738-745
Liquid-liquid phase separation (LLPS) of protein solutions has been usually related to strong protein-protein interactions (PPI) under certain conditions. For the first time, we observed the LLPS phenomenon for a novel protein modality, peptide-fused
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74142b1cb7f104fbbbb44f03d243d218
https://doi.org/10.1016/j.xphs.2020.09.020
https://doi.org/10.1016/j.xphs.2020.09.020
Autor:
Yves Aubin, Steven A. Berkowitz, George M. Bou-Assaf, Mark L. Brader, Richard K. Burdick, John F. Carpenter, Stephen J. Demarest, Ertan Eryilmaz, Verna Frasca, Darron L. Freedberg, John P. Gabrielson, Andrea Hawe, Damian J. Houde, David A. Keire, Francis Kinderman, Lee Makowski, John P. Marino, Alan G. Marshall, A.J. Miles, John S. Philo, Angelika Reichel, Deniz B. Temel, B.A. Wallace, Daniel Weinbuch, William F. Weiss IV, Sarah Zölls
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8f1ba2bdc0d6cf5768a0331548186954
https://doi.org/10.1016/b978-0-444-64173-1.01002-7
https://doi.org/10.1016/b978-0-444-64173-1.01002-7
Autor:
Mengmeng Xu, James Angelo, Zheng Jian Li, Christopher Oliveira, Sanchayita Ghose, Chao Huang, Julia Ding, Xuankuo Xu, Deniz B. Temel, Jianlin Xu, Michael C. Borys, Xia Xu
Publikováno v:
mAbs
article-version (VoR) Version of Record
article-version (VoR) Version of Record
Process intensification has shown great potential to increase productivity and reduce costs in biomanufacturing. This case study describes the evolution of a manufacturing process from a conventional processing scheme at 1000-L scale (Process A, n =
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3e2974853c6954722e6d5ee9038f5e8
https://doi.org/10.1080/19420862.2020.1770669
https://doi.org/10.1080/19420862.2020.1770669
Publikováno v:
Journal of Pharmaceutical Sciences. 105:3278-3289
Characterization of immunoglobulin solutions at high concentrations represents a significant challenge. A current trend in the biopharmaceutical industry is to manufacture highly concentrated drug products, which can be used to deliver high doses in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74f3046ad95cd0f5542247e1cee875c8
https://doi.org/10.1016/j.xphs.2016.07.021
https://doi.org/10.1016/j.xphs.2016.07.021
Autor:
Olivia Henderson, Pavel Landsman, Deniz B. Temel, Andrea Spencer, Mark L. Brader, Fabian Vega, Damian Houde, Shujun Bai, Daniel P. DeCollibus
Publikováno v:
Journal of Pharmaceutical Sciences. 105:50-63
The evaluation of stability with respect to particles in prefilled syringes is complicated by the presence of silicone oil. The mobility, colloidal characteristics, and kinetic instability of silicone oil in contact with a protein formulation may be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68d7a7a76bed483f63041b9ff1447a08
https://doi.org/10.1016/j.xphs.2015.10.012
https://doi.org/10.1016/j.xphs.2015.10.012
Publikováno v:
The FASEB Journal. 32
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d1d4bf6e738e93e1c846e1b29690e3df
https://doi.org/10.1096/fasebj.2018.32.1_supplement.652.29
https://doi.org/10.1096/fasebj.2018.32.1_supplement.652.29
The largely intrinsically disordered phenylalanine-glycine-rich nucleoporins (FG Nups) underline a selectivity mechanism, which enables the rapid translocation of transport factors (TFs) through the nuclear pore complexes (NPCs). Conflicting models o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::644758f908abfbd31db11071c23239b9
Autor:
Laura Maguire, Kaushik Dutta, Michael P. Rout, Deniz B. Temel, Alia Kamal, Kathryn P. Wall, Jaclyn Tetenbaum-Novatt, Geoff Armstrong, Loren E. Hough, Samuel Sparks, David Cowburn
Publikováno v:
Biophysical Journal. 110(3)
Nuclear pore complexes form a selective filter that allows the rapid passage of transport factors and their cargoes across the nuclear envelope, while blocking the passage of other macromolecules. Intrinsically disordered proteins (IDPs) containing p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85a6b17bdcd5b6d6c6e69e51f0af674d
Publikováno v:
Methods in enzymology. 567
Evaluating prospective protein pharmaceutical stability from accelerated screening is a critical challenge in biotherapeutic discovery and development. Measurements of protein unfolding transitions are widely employed for comparing candidate molecule
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6a4ce0130f736008bc361af8af49ec4d
https://pubmed.ncbi.nlm.nih.gov/26794361
https://pubmed.ncbi.nlm.nih.gov/26794361