Zobrazeno 1 - 10
of 169
pro vyhledávání: '"Deniz, Dalkara"'
Autor:
Juliette Pulman, Catherine Botto, Hugo Malki, Duohao Ren, Paul Oudin, Anne De Cian, Marie As, Charlotte Izabelle, Bruno Saubamea, Valerie Forster, Stéphane Fouquet, Camille Robert, Céline Portal, Aziz El-Amraoui, Sylvain Fisson, Jean-Paul Concordet, Deniz Dalkara
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 35, Iss 4, Pp 102349- (2024)
Genome editing by CRISPR-Cas holds promise for the treatment of retinal dystrophies. For therapeutic gene editing, transient delivery of CRISPR-Cas9 is preferable to viral delivery which leads to long-term expression with potential adverse consequenc
Externí odkaz:
https://doaj.org/article/79b809bb916648639568bb98681ed82b
Autor:
Takahiro Nemoto, Tommaso Ocari, Arthur Planul, Muge Tekinsoy, Emilia A. Zin, Deniz Dalkara, Ulisse Ferrari
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-11 (2023)
Abstract Forward genetic screens of mutated variants are a versatile strategy for protein engineering and investigation, which has been successfully applied to various studies like directed evolution (DE) and deep mutational scanning (DMS). While nex
Externí odkaz:
https://doaj.org/article/ca14d5d691344b0d9cf2055c415a56e5
Autor:
Hanen Khabou, Elaine Orendorff, Francesco Trapani, Marco Rucli, Melissa Desrosiers, Pierre Yger, Deniz Dalkara, Olivier Marre
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 31, Iss , Pp 101107- (2023)
Most inherited retinal dystrophies display progressive photoreceptor cell degeneration leading to severe visual impairment. Optogenetic reactivation of inner retinal neurons is a promising avenue to restore vision in retinas having lost their photore
Externí odkaz:
https://doaj.org/article/b78a68eae9bd436db9cd81cc7fa020a7
Autor:
Ophélie Vacca, Faouzi Zarrouki, Charlotte Izabelle, Mehdi Belmaati Cherkaoui, Alvaro Rendon, Deniz Dalkara, Cyrille Vaillend
Publikováno v:
Cells, Vol 13, Iss 8, p 718 (2024)
A deficiency in the shortest dystrophin-gene product, Dp71, is a pivotal aggravating factor for intellectual disabilities in Duchenne muscular dystrophy (DMD). Recent advances in preclinical research have achieved some success in compensating both mu
Externí odkaz:
https://doaj.org/article/eca27be8b77145bdab86d84d8f2672b5
Autor:
Laia Sitjà Roqueta, Neville M Ngum, Melike küçükerden, Sara Conde Berriozabal, Yihe Zhang, Alba Ramon-Lainez, Anna Castañé, Manuel J Rodríguez, Jordi Alberch, Deniz Dalkara, Andreas Möglich, H Rheinallt Parri, Mercè Masana
Publikováno v:
IBRO Neuroscience Reports, Vol 15, Iss , Pp S501-S502 (2023)
Externí odkaz:
https://doaj.org/article/71fd803393bd49059746708f9b61aaa6
Autor:
Melike küçükerden, Laia Sitjà Roqueta, Albert Coll-Manzano, Sara Conde Berriozabal, Esther García García, Alba Ramon-Lainez, Sara Fernández García, H Rheinallt Parri, Manuel J Rodríguez, Deniz Dalkara, Andreas Möglich, Jordi Alberch, Jordi Soriano, Mercè Masana
Publikováno v:
IBRO Neuroscience Reports, Vol 15, Iss , Pp S350- (2023)
Externí odkaz:
https://doaj.org/article/e746ccd5ef384ff5a6193e0deddd5501
Autor:
Divya Ail, Duohao Ren, Elena Brazhnikova, Céline Nouvel-Jaillard, Stephane Bertin, Seyed Bagher Mirashrafi, Sylvain Fisson, Deniz Dalkara
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 24, Iss , Pp 306-316 (2022)
Positive clinical outcomes in adeno-associated virus (AAV)-mediated retinal gene therapy have often been attributed to the low immunogenicity of AAVs and immune privilege of the eye. However, several recent studies have shown potential for inflammato
Externí odkaz:
https://doaj.org/article/5f1307aa30894217bbe9ecb9a1d4feef
Autor:
Malou Dongelmans, Romain Durand-de Cuttoli, Claire Nguyen, Maxime Come, Etienne K. Duranté, Damien Lemoine, Raphaël Brito, Tarek Ahmed Yahia, Sarah Mondoloni, Steve Didienne, Elise Bousseyrol, Bernadette Hannesse, Lauren M. Reynolds, Nicolas Torquet, Deniz Dalkara, Fabio Marti, Alexandre Mourot, Jérémie Naudé, Philippe Faure
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Chronic nicotine exposure impacts various components of decision-making processes, such as exploratory behaviors. Here, the authors identify the cellular mechanism and show that chronic nicotine exposure increases the tonic activity of VTA dopaminerg
Externí odkaz:
https://doaj.org/article/ad5caf779392407fa4039e76c1116fb7
Autor:
Juliette Varin, Nassima Bouzidi, Gregory Gauvain, Corentin Joffrois, Melissa Desrosiers, Camille Robert, Miguel Miranda De Sousa Dias, Marion Neuillé, Christelle Michiels, Marco Nassisi, José-Alain Sahel, Serge Picaud, Isabelle Audo, Deniz Dalkara, Christina Zeitz
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 22, Iss , Pp 15-25 (2021)
Complete congenital stationary night blindness (cCSNB) due to mutations in TRPM1, GRM6, GPR179, NYX, or leucine-rich repeat immunoglobulin-like transmembrane domain 3 (LRIT3) is an incurable inherited retinal disorder characterized by an ON-bipolar c
Externí odkaz:
https://doaj.org/article/1f04f05b98504f5194e6bd3d6cde288d
Autor:
Gregory Gauvain, Himanshu Akolkar, Antoine Chaffiol, Fabrice Arcizet, Mina A. Khoei, Mélissa Desrosiers, Céline Jaillard, Romain Caplette, Olivier Marre, Stéphane Bertin, Claire-Maelle Fovet, Joanna Demilly, Valérie Forster, Elena Brazhnikova, Philippe Hantraye, Pierre Pouget, Anne Douar, Didier Pruneau, Joël Chavas, José-Alain Sahel, Deniz Dalkara, Jens Duebel, Ryad Benosman, Serge Picaud
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-15 (2021)
Gauvain et al demonstrate that optogenetic therapy using the AAV2.7m8- ChR-tdT construct can partially restore vision in non-human primates to levels above those considered legally-blind. This study enables the identification of the most suitable con
Externí odkaz:
https://doaj.org/article/0b4ca90d06f64da69afaff7c49d68f90