Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Denisse L. Leyton"'
Autor:
Daniel Fox, Anukriti Mathur, Yansong Xue, Yunqi Liu, Wei Hong Tan, Shouya Feng, Abhimanu Pandey, Chinh Ngo, Jenni A. Hayward, Ines I. Atmosukarto, Jason D. Price, Matthew D. Johnson, Nadja Jessberger, Avril A. B. Robertson, Gaetan Burgio, David C. Tscharke, Edward M. Fox, Denisse L. Leyton, Nadeem O. Kaakoush, Erwin Märtlbauer, Stephen H. Leppla, Si Ming Man
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
The Bacillus haemolytic enterotoxin haemolysin BL has been shown to activate the NLRP3 inflammasome. Here the authors show that a non-haemolytic enterotoxin (NHE) from B. cereus can also activate the NLRP3 inflammasome with a similar mechanism of lyt
Externí odkaz:
https://doaj.org/article/a3d1c668fd514f4c9ccf1972f0c941e9
Autor:
Xiaojun Yuan, Matthew D. Johnson, Jing Zhang, Alvin W. Lo, Mark A. Schembri, Lakshmi C. Wijeyewickrema, Robert N. Pike, Gerard H. M. Huysmans, Ian R. Henderson, Denisse L. Leyton
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Autotransporter passenger domains are presented on or released from the bacterial surface upon translocation through an outer membrane β-barrel anchor. Here the authors study the two E. coli autotransporters Pet and EspP and propose that the β-barr
Externí odkaz:
https://doaj.org/article/f98a1b1242774a1e9a6565cc46622c09
Autor:
Denisse L. Leyton, David C. Tscharke, Nadja Jessberger, Edward M. Fox, Abhimanu Pandey, Jason D. Price, Daniel Fox, Gaetan Burgio, Si Ming Man, Chinh Ngo, Jenni A. Hayward, Erwin Märtlbauer, Anukriti Mathur, Shouya Feng, Wei Hong Tan, Stephen H. Leppla, Yansong Xue, Ines Atmosukarto, Nadeem O. Kaakoush, Avril A. B. Robertson, Matthew D. Johnson, Yunqi Liu
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Nature Communications
Nature Communications
Inflammasomes are important for host defence against pathogens and homeostasis with commensal microbes. Here, we show non-haemolytic enterotoxin (NHE) from the neglected human foodborne pathogen Bacillus cereus is an activator of the NLRP3 inflammaso
Autor:
Jennifer C Tsai, Ming-Ren Yen, Rostislav Castillo, Denisse L Leyton, Ian R Henderson, Milton H Saier
Publikováno v:
PLoS ONE, Vol 5, Iss 12, p e14403 (2010)
Gram-negative bacteria have developed a limited repertoire of solutions for secreting proteins from the cytoplasmic compartment to the exterior of the cell. Amongst the spectrum of secreted proteins are the intimins and invasins (the Int/Inv family;
Externí odkaz:
https://doaj.org/article/ba8be97cf14640d4b6616d319bfd464a
Autor:
Esther Braselmann, James P. Nataro, Harris D. Bernstein, Julie L. Chaney, Patricia L. Clark, Denisse L. Leyton, Trevor Lithgow, Igor Drobnak, Joen Luirink
Publikováno v:
Molecular Microbiology. 95:1-16
Autotransporter (AT) proteins provide a diverse array of important virulence functions to Gram-negative bacterial pathogens, and have also been adapted for protein surface display applications. The 'autotransporter' moniker refers to early models tha
Autor:
Jing Zhang, Robert N. Pike, Lakshmi C. Wijeyewickrema, Mark A. Schembri, Denisse L. Leyton, Alvin W. Lo, Matthew D. Johnson, Ian R. Henderson, Gerard H. M. Huysmans, Xiaojun Yuan
Publikováno v:
Nature Communications
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Bacterial autotransporters comprise a C-terminal β-barrel domain, which must be correctly folded and inserted into the outer membrane to facilitate translocation of the N-terminal passenger domain to the cell exterior. Once at the surface, the passe
Autor:
Timothy J. Wells, Richard A. Strugnell, Anthony W. Purcell, Nermin Celik, Chaille T. Webb, Sri H. Ramarathinam, Daniel Walker, Joel Selkrig, Minh-Duy Phan, Clare V. Oates, Elizabeth L. Hartland, Faye C. Morris, Roy M. Robins-Browne, Trevor Lithgow, Matthew J. Belousoff, Mark A. Schembri, Denisse L. Leyton, Ian R. Henderson, Khedidja Mosbahi, Andrew J. Perry, Michelle Kelly, Makrina Totsika
Publikováno v:
Nature Structural & Molecular Biology. 19:506-510
Bacteria have mechanisms to export proteins for diverse purposes, including colonization of hosts and pathogenesis. A small number of archetypal bacterial secretion machines have been found in several groups of bacteria and mediate a fundamentally di
From self sufficiency to dependence: mechanisms and factors important for autotransporter biogenesis
Publikováno v:
Nature Reviews Microbiology. 10:213-225
Autotransporters are a superfamily of proteins that use the type V secretion pathway for their delivery to the surface of Gram-negative bacteria. At first glance, autotransporters look to contain all the functional elements required to promote their
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1329
The outer membranes of gram-negative bacteria contain integral membrane proteins, most of which are of β-barrel structure, and critical for bacterial survival. These β-barrel proteins rely on the β-barrel assembly machinery (BAM) complex for their
Autor:
Robin C. May, Calman A. MacLennan, John Pravin, Duncan J. Maskell, Sarah Peters, Claudia T. P. Moraes, Karina Tveen Jensen, Douglas F. Browning, Ian R. Henderson, Dhaarini Raghunathan, Adriana Flores-Langarica, Roxane M. F. Piazza, Jessica Hitchcock, Laura J. V. Piddock, Mark A. Webber, Timothy J. Wells, Faye C. Morris, Gavin K. Paterson, Denisse L. Leyton, Saeeda Bobat, Jessica M A Blair, Adam F. Cunningham, Robert K. Shaw
Publikováno v:
Infection and Immunity. 79:4342-4352
Salmonella enterica is a major cause of morbidity worldwide and mortality in children and immunocompromised individuals in sub-Saharan Africa. Outer membrane proteins of Salmonella are of significance because they are at the interface between the pat