Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Denise da Gama Jaen, Batista"'
Autor:
Cassandra Present, Roberson Donola Girão, Cai Lin, Guy Caljon, Serge Van Calenbergh, Otacilio Moreira, Leonardo Alexandre de Souza Ruivo, Marcos Meuser Batista, Raquel Azevedo, Denise da Gama Jaen Batista, Maria de Nazaré Correia Soeiro
Publikováno v:
Parasitology, Vol 151, Pp 506-513 (2024)
Leishmania is a trypanosomatid parasite that causes skin lesions in its cutaneous form. Current therapies rely on old and expensive drugs, against which the parasites have acquired considerable resistance. Trypanosomatids are unable to synthesize pur
Externí odkaz:
https://doaj.org/article/fdbc09b2ce2b46c1a1ac11bb0c9763fd
Autor:
Daiane Dias Ferreira, Juliana Tonini Mesquita, Thais Alves da Costa Silva, Maiara Maria Romanelli, Denise da Gama Jaen Batista, Cristiane França da Silva, Aline Nefertiti Silva da Gama, Bruno Junior Neves, Cleber Camilo Melo-Filho, Maria de Nazare Correia Soeiro, Carolina Horta Andrade, Andre Gustavo Tempone
Publikováno v:
Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 24, Iss 1, Pp 1-12 (2018)
Abstract Background Drug repurposing has been an interesting and cost-effective approach, especially for neglected diseases, such as Chagas disease. Methods In this work, we studied the activity of the antidepressant drug sertraline against Trypanoso
Externí odkaz:
https://doaj.org/article/5fea82da8c5541068b69e7ccd07d156e
Autor:
Natália Lins da Silva-Gomes, Leonardo Alexandre de Souza Ruivo, Claudia Moreira, Marcelo Meuser-Batista, Cristiane França da Silva, Denise da Gama Jaen Batista, Stênio Fragoso, Gabriel Melo de Oliveira, Maria de Nazaré Correia Soeiro, Otacilio C. Moreira
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 23; Pages: 14661
Ecto-nucleoside triphosphate diphosphohydrolases (NTPDases) are enzymes located on the surface of the T.cruzi plasma membrane, which hydrolyze a wide range of tri-/-diphosphate nucleosides. In this work, we used previously developed genetically modif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11232c6cf23c07e9e4ff2e9a36507540
Autor:
Natália Lins da, Silva-Gomes, Leonardo Alexandre de Souza, Ruivo, Claudia, Moreira, Marcelo, Meuser-Batista, Cristiane França da, Silva, Denise da Gama Jaen, Batista, Stênio, Fragoso, Gabriel Melo de, Oliveira, Maria de Nazaré Correia, Soeiro, Otacilio C, Moreira
Publikováno v:
International journal of molecular sciences. 23(23)
Ecto-nucleoside triphosphate diphosphohydrolases (NTPDases) are enzymes located on the surface of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::11e6e486dce972b778fced531cedf93f
https://pubmed.ncbi.nlm.nih.gov/36498985
https://pubmed.ncbi.nlm.nih.gov/36498985
Autor:
Darliane A. Martins, Ligiane R. Gouvea, Gabriel S. Vignoli Muniz, Sonia R. W. Louro, Denise da Gama Jaen Batista, Maria de Nazaré C. Soeiro, Letícia R. Teixeira
Publikováno v:
Bioinorganic Chemistry and Applications, Vol 2016 (2016)
Copper(II) complexes with the first-generation quinolone antibacterial agent norfloxacin containing a nitrogen donor heterocyclic ligand 2,2′-bipyridine (bipy) or 1,10-phenanthroline (phen) were prepared and characterized by IR, EPR spectra, molar
Externí odkaz:
https://doaj.org/article/af50bbd6199d4a848f33d09b9d992f99
Autor:
Denise da Gama Jaen Batista, Alicia Gómez-Barrio, José Antonio Escario, Vicente J. Arán, Cristiane França da Silva, Maria de Nazaré Correia Soeiro, Raiza Brandão Peres, Gabriel Melo de Oliveira, A. S. G. Nefertiti, José Cumella, Marcos Meuser Batista, Cristina Fonseca-Berzal
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
instname
In previous studies, we have identified several families of 5-nitroindazole derivatives as promising antichagasic prototypes. Among them, 1-(2-aminoethyl)-2-benzyl-5-nitro-1,2-dihydro-3H-indazol-3-one, (hydrochloride) and 1-(2-acetoxyethyl)-2-benzyl-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c1118d1fa4a53698738b806b85c7610
https://doi.org/10.1017/s0031182020000955
https://doi.org/10.1017/s0031182020000955
Autor:
Natália Lins da Silva Gomes, Camila Cardoso-Santos, Ana Lia Mazzeti, Ludmila Ferreira de Almeida Fiuza, Denise da Gama Jaen Batista, Cristiane França da Silva, Serge Van Calenbergh, Maria de Nazaré Correia Soeiro, Guy Caljon, Otacilio C. Moreira, Gabriel Melo de Oliveira, Louis Maes, Fabian Hulpia, Roberson Donola Girão
Publikováno v:
JAC-ANTIMICROBIAL RESISTANCE
JAC-Antimicrobial Resistance
JAC-Antimicrobial Resistance
Background The protozoan Trypanosoma cruzi is auxotrophic for purines and causes Chagas’ disease (CD), a neglected illness affecting >6 million people. Combining the 3-deoxyribofuranose part of cordycepin with the modified purine ring of a nucleosi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1731847b948decd661e97223fc6ed64e
https://doi.org/10.1093/jacamr/dlab168
https://doi.org/10.1093/jacamr/dlab168
Autor:
Camila, Cardoso-Santos, Ludmila, Ferreira de Almeida Fiuza, Cristiane, França da Silva, Ana Lia, Mazzeti, Roberson, Donola Girão, Gabriel, Melo de Oliveira, Denise, da Gama Jaen Batista, Otacilio, Cruz Moreira, Natália, Lins da Silva Gomes, Louis, Maes, Guy, Caljon, Fabian, Hulpia, Serge V, Calenbergh, Maria de Nazaré, Correia Soeiro
Publikováno v:
JAC-Antimicrobial Resistance
Background The protozoan Trypanosoma cruzi is auxotrophic for purines and causes Chagas’ disease (CD), a neglected illness affecting >6 million people. Combining the 3-deoxyribofuranose part of cordycepin with the modified purine ring of a nucleosi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d5bc5c8641b80fbd32683fb5beec9c6c
https://pubmed.ncbi.nlm.nih.gov/34806007
https://pubmed.ncbi.nlm.nih.gov/34806007
Autor:
Kristof Van Hecke, Guy Caljon, Denise da Gama Jaen Batista, Cai Lin, Fabian Hulpia, Louis Maes, Serge Van Calenbergh, Maria de Nazaré Correia Soeiro, Cristiane França da Silva
Publikováno v:
Journal of medicinal chemistry
Trypanosoma cruzi is the causative pathogen of Chagas disease and the main culprit for cardiac-related mortality in Latin-America triggered by an infective agent. Uncapable of synthesizing purines de novo, this parasite depends on acquisition and pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07c45766adae8b607a6408d1229d9126
https://doi.org/10.1021/acs.jmedchem.9b01275
https://doi.org/10.1021/acs.jmedchem.9b01275
Autor:
Galina I. Lepesheva, Marcos Meuser Batista, Constança Britto, Beatriz Philot Pavão, Denise da Gama Jaen Batista, Fernando Villalta, Leticia Rocha Quintino Souza, Cristiane França da Silva, Girish Rachakonda, Otacilio C. Moreira, F. H. Guedes-da-Silva, Maria de Nazaré Correia Soeiro
Publikováno v:
ACS Infectious Diseases. 5:365-371
Up to now, no vaccines are available for Chagas disease, and the current therapy is largely unsatisfactory. Novel imidazole-based scaffolds of protozoan sterol 14α-demethylase (CYP51) inhibitors have demonstrated potent antiparasitic activity with n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f2df7e65f9f2b952ecb5f19c71c2cb0
https://doi.org/10.1021/acsinfecdis.8b00253
https://doi.org/10.1021/acsinfecdis.8b00253