Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Denise Zembryki"'
Autor:
Eric P. Winer, Paolo Paoletti, Debasish Roychowdhury, Cristina Oliva, Denise Zembryki, Klaudia Steplewski, Bernie Dharan, Stephen D. Rubin, Joanne L. Blum, Adam Brufsky, Denise Yardley, Andrew Wardley, Stefania Gori, Sibylle Loibl, Eva Ciruelos, Richard Greil, Minetta C. Liu, Henri Roché, Hans-Joachim Stemmler, Christos Christodoulou, Dominique Lossignol, Devchand Paul, Véronique Diéras, Nancy U. Lin
Purpose: Brain metastases develop in one third of patients with advanced HER2+ breast cancer. Effective therapy for patients with central nervous system (CNS) progression after cranial radiation is extremely limited and represents a major clinical ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b28dc6c170e4838f473d40e9f1c8e4f
https://doi.org/10.1158/1078-0432.c.6517522
https://doi.org/10.1158/1078-0432.c.6517522
Autor:
Eric P. Winer, Paolo Paoletti, Debasish Roychowdhury, Cristina Oliva, Denise Zembryki, Klaudia Steplewski, Bernie Dharan, Stephen D. Rubin, Joanne L. Blum, Adam Brufsky, Denise Yardley, Andrew Wardley, Stefania Gori, Sibylle Loibl, Eva Ciruelos, Richard Greil, Minetta C. Liu, Henri Roché, Hans-Joachim Stemmler, Christos Christodoulou, Dominique Lossignol, Devchand Paul, Véronique Diéras, Nancy U. Lin
Supplementary Data from Multicenter Phase II Study of Lapatinib in Patients with Brain Metastases from HER2-Positive Breast Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56d13815d0dc2df0ff0ad271f6254216
https://doi.org/10.1158/1078-0432.22440151.v1
https://doi.org/10.1158/1078-0432.22440151.v1
Autor:
Debasish F. Roychowdhury, Henri Roché, Hans-Joachim Stemmler, Cristina Oliva, Joanne L. Blum, Paolo Paoletti, Minetta C. Liu, Richard Greil, Devchand Paul, Dominique Lossignol, Denise A. Yardley, Denise Zembryki, Eric P. Winer, Sibylle Loibl, Nan Lin, Christos Christodoulou, Stephen D. Rubin, Eva Ciruelos, Bernie Dharan, Stefania Gori, Andrew M Wardley, Klaudia Steplewski, Adam Brufsky, Véronique Diéras
Publikováno v:
Clinical Cancer Research. 15:1452-1459
Purpose: Brain metastases develop in one third of patients with advanced HER2+ breast cancer. Effective therapy for patients with central nervous system (CNS) progression after cranial radiation is extremely limited and represents a major clinical ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3640e97ec8c0d3be765c0aa7b751d1ca
https://doi.org/10.1158/1078-0432.ccr-08-1080
https://doi.org/10.1158/1078-0432.ccr-08-1080
Autor:
Maxine Gowen, Catherine J. Gress, Shing Mei Hwang, Michael W. Lark, Michael S. McQueney, Ian E. James, Robert W. Marquis, Simon M. Blake, Ru Yu, Daniel F. Veber, Hye-Ja Oh, Denise Zembryki, Thaddeus A. Tomaszek, Dennis S. Yamashita
Publikováno v:
Journal of Biological Chemistry. 276:11507-11511
Cathepsins K and L are related cysteine proteases that have been proposed to play important roles in osteoclast-mediated bone resorption. To further examine the putative role of cathepsin L in bone resorption, we have evaluated selective and potent i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::892b89bfe824acabaf8fa273601f5802
https://doi.org/10.1074/jbc.m010684200
https://doi.org/10.1074/jbc.m010684200
Autor:
David J. Rieman, William F. Huffaman, Kevin L. Salyers, Richard M. Keenan, Michael W. Lark, Janice A. Vasko-Moser, Thomas W. Ku, Maxine Gowen, Leonard M. Azzarano, Karl F. Erhard, Stephen T. Ross, Denise Zembryki, Bradbeer Jeremy N, Bondinell William E, Shing-Mei Hwang, William H. Miller, Kenneth A. Newlander, George B. Stroup, Beata Lechowska, Fred H. Drake, Keith W. Ward, Kyung O. Johanson, Brian R. Smith, Paula C. Adams, Ian E. James, R. Curtis Haltiwanger, Russell D. Cousins, Dalia R. Jakas, Sandra J. Hoffman
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 9:1807-1812
A new series of potent nonpeptide vitronectin receptor antagonists, based on a novel carbocyclic Gly-Asp mimetic, has been discovered. A representative of this series, SB 265123 (4), has 100% oral bioavailability in rats, and is orally active in vivo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49bebe15e69e0b6c6398f79a6e04504c
https://doi.org/10.1016/s0960-894x(99)00283-8
https://doi.org/10.1016/s0960-894x(99)00283-8
Autor:
Stephen R. Lane, Denise Zembryki, Wolfgang Eierman, Nan Lin, Richard Greil, Stephen D. Rubin, Mario Campone, Klaudia Steplewski, Bella Kaufman, Eric P. Winer
Publikováno v:
Journal of neuro-oncology. 105(3)
Approximately one-third of patients with advanced, HER2-positive breast cancer develop brain metastases. A significant proportion of women experience central nervous system (CNS) progression after standard radiation therapy. The optimal treatment in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56906bc4e74c471fd2b99576801828f4
https://pubmed.ncbi.nlm.nih.gov/21706359
https://pubmed.ncbi.nlm.nih.gov/21706359
Autor:
Shin-Cheh Chen, John S. Link, Jungsil Ro, S. De Placido, Roma Parikh, Pierfranco Conte, K. Cwiertka, S.R.D. Johnston, Denise Zembryki, Guy Jerusalem, Z. Jiang, G. Capri, Cristina Oliva, J. Rosenlund, A. Preston, Bella Kaufman, J. Schutte, J. Chang, M. Selzer
Publikováno v:
Annals of oncology : official journal of the European Society for Medical Oncology. 21(3)
Background: The Lapatinib Expanded Access Program (LEAP) was designed to provide access to lapatinib plus capecitabine for HER2-positive metastatic breast cancer patients who previously received an anthracycline, a taxane, and a trastuzumab and had n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f08b677078bfd4c9721c2a8824ae098
https://pubmed.ncbi.nlm.nih.gov/19815649
https://pubmed.ncbi.nlm.nih.gov/19815649
Autor:
Jae U. Jeong, Keith W. Ward, Enoch Gao, Dennis S. Yamashita, Bing Wang, § H-Y. Cheng, Baoguang Zhao, Martha S. Head, Amy A. Sarjeant, § Louise M. Liable-Sands, Ian E. James, Neysa Nevins, Ren Xie, and Michael W. Lark, Karl F. Erhard, Denise Zembryki, Daniel F. Veber, Theresa J. Roethke, Robert W. Marquis, Brian R. Smith, Xiaoliu Geng, Michael S. McQueney, R. Curtis Haltiwanger, Ward W. Smith, Sirishkumar D. Nidamarthy, Catherine J. Gress, Priscilla H. Offen, Hye-Ja Oh, Cheryl A. Janson, Thaddeus A. Tomaszek, Fan Lin
Publikováno v:
Journal of medicinal chemistry. 49(5)
The syntheses, in vitro characterizations, and rat and monkey in vivo pharmacokinetic profiles of a series of 5-, 6-, and 7-methyl-substituted azepanone-based cathepsin K inhibitors are described. Depending on the particular regiochemical substitutio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87988c095a79f414b77817c8a504f022
https://pubmed.ncbi.nlm.nih.gov/16509577
https://pubmed.ncbi.nlm.nih.gov/16509577
Autor:
Elizabeth Lee-Rykaczewski, Ian E. James, Denise Zembryki, Michael W. Lark, Thaddeus A. Tomaszek, Pietro Belfiore, Maxine Gowen, Shing Mei Hwang
Publikováno v:
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 14(9)
A human in vitro resorption assay has been developed using osteoclastoma-derived osteoclasts and used to evaluate novel antiresorptive agents including antagonists of the alphavbeta3 integrin, and inhibitors of cathepsin K and the osteoclast ATPase.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b51a48f5d7f29acf1af3646b8840b91
https://pubmed.ncbi.nlm.nih.gov/10469285
https://pubmed.ncbi.nlm.nih.gov/10469285
Autor:
Carlo Parini, I. Delimoge, Pietro Belfiore, Elizabeth Lee-Rycakzewski, Marcel Morvan, Emanuela Consolandi, Andrea Zocchetti, Carlo Farina, Denise Zembryki, Stefania Gagliardi, Ian E. James, Guy Marguerite Marie Gerard Nadler
Publikováno v:
Bioorganicmedicinal chemistry letters. 8(24)
Optimisation of a novel series of osteoclast ATPase inhibitors led to (2Z,4E)-5-(5,6-dichloro-2-indolyl)-2-methoxy-N-(1,2,2,6,6- pentamethylpiperidin-4-yl)-2,4-pentadienamide (1) that was the most potent compound in an in vitro osteoclast ATPase assa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fd2cacd93d7abd64429001c60466f90
https://pubmed.ncbi.nlm.nih.gov/9934482
https://pubmed.ncbi.nlm.nih.gov/9934482