Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Denise Sickert"'
Autor:
Shannon L. Maude, Patricia A. Wood, Tetiana Taran, Mimi Leung, Sweta S. Shah, Lori Tomassian, Carl H. June, Bruce L. Levine, Abhijit Chakraborty, Denise Sickert, Andrew M. Stein, Rakesh Awasthi, Jason Hamilton, Keith J. August, Michael W. Boyer, Michael A. Pulsipher, Theodore W. Laetsch, John E. Levine, Stephan A. Grupp, Edward Waldron, Karen Thudium Mueller
Supplementary Data
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d26112761ad0dea9547df85ecdd32fd
https://doi.org/10.1158/1078-0432.22468554.v1
https://doi.org/10.1158/1078-0432.22468554.v1
Autor:
Shannon L. Maude, Patricia A. Wood, Tetiana Taran, Mimi Leung, Sweta S. Shah, Lori Tomassian, Carl H. June, Bruce L. Levine, Abhijit Chakraborty, Denise Sickert, Andrew M. Stein, Rakesh Awasthi, Jason Hamilton, Keith J. August, Michael W. Boyer, Michael A. Pulsipher, Theodore W. Laetsch, John E. Levine, Stephan A. Grupp, Edward Waldron, Karen Thudium Mueller
Purpose:Tisagenlecleucel is an anti-CD19 chimeric antigen receptor (CAR19) T-cell therapy approved for the treatment of children and young adults with relapsed/refractory (r/r) B-cell acute lymphoblastic leukemia (B-ALL).Patients and Methods:We evalu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2966852df65c2babfb4fccdcb3c7560
https://doi.org/10.1158/1078-0432.c.6526989.v1
https://doi.org/10.1158/1078-0432.c.6526989.v1
Autor:
Michael A. Pulsipher, Carl H. June, Jason Hamilton, Shannon L. Maude, Michael Boyer, Rakesh Awasthi, Bruce L. Levine, Keith J. August, Lori Tomassian, Mimi Leung, Theodore W. Laetsch, Andrew M. Stein, Edward Waldron, Sweta Shah, Tetiana Taran, Denise Sickert, Karen Thudium Mueller, Abhijit Chakraborty, Stephan A. Grupp, Patricia A. Wood, John E. Levine
Publikováno v:
Clin Cancer Res
Purpose: Tisagenlecleucel is an anti-CD19 chimeric antigen receptor (CAR19) T-cell therapy approved for the treatment of children and young adults with relapsed/refractory (r/r) B-cell acute lymphoblastic leukemia (B-ALL). Patients and Methods: We ev
Autor:
Viswanath Devanarayan, Simon Cowen, Michaela Golob, Daniel Kramer, Jim McNally, Venke Skibeli, David Egging, Marianne Scheel Fjording, Robert Nelson, Timo Piironen, Thomas Emrich, Joao Pedras-Vasconcelos, Denise Sickert, Philip Timmerman, James Munday, Joanne Goodman
Publikováno v:
Bioanalysis. 10:197-204
European Bioanalysis Forum Workshop, Lisbon, Portugal, September 2016: At the recent European Bioanalysis Forum Focus Workshop, ‘current analysis of immunogenicity: best practices and regulatory hurdles’, several important challenges facing the b
Publikováno v:
Journal of immunological methods. 476
The use of T-cells expressing Chimeric Antigen Receptors (CARs) offers new opportunities for cancer treatment, as well as new challenges for the bioanalysis of this new class of drugs. The analysis of humoral immunogenicity (anti-drug antibodies) aga
Autor:
Roland Schuler, Michael Rotte, Yan-Ling He, Peter Gergely, Pascal Espie, Laurence Colin, Anita Auger, Heidi Mergentaler, Martha Hernandez‐Illas, James S. Rush, Jacinda Ristov, Julie Milojevic, Denise Sickert, Cyrielle Dupuy, Alexandre Avrameas, Edwige Chokote, Phillip Koo, Aurelie Verles, Andrea Groenewegen, Charles S. Tomek
Publikováno v:
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant SurgeonsReferences. 20(2)
Iscalimab is a fully human, CD40 pathway blocking, nondepleting monoclonal antibody being developed as an immunosuppressive agent. We describe a first-in-human, randomized, double-blind, placebo-controlled study investigating the safety, tolerability
Autor:
Tina Rubic-Schneider, Pascal Espie, Thierry Flandre, Denise Sickert, David Andrew Shaw, James S. Rush, Peter Ulrich
Publikováno v:
Toxicological Sciences.
CFZ533 is a pathway blocking, nondepleting anti-CD40 antibody that is in clinical development for inhibition of transplant organ rejection and therapy for autoimmune diseases. A 26-week GLP toxicity study in sexually mature Cynomolgus monkeys was con
Autor:
James S. Rush, Christoph Heusser, Dorothee Müller-Ristig, Peter Ulrich, Christian Bruns, Pascal Espie, Gautier Robert, Doris Weider, Patrick Schmutz, Serge Côté, Max Warncke, Jacinda Ristov, Frank Kolbinger, Francisco Cordoba-Castro, Thierry Flandre, Denise Sickert, Barbara Greutmann, Martin A. Schneider, Mirela Dimitrova
Publikováno v:
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 18(12)
The CD40-CD154 costimulatory pathway is essential for T cell-dependent immune responses, development of humoral memory, and antigen presenting cell function. These immune functions have been implicated in the pathology of multiple autoimmune diseases
Autor:
Tetiana Taran, Jason Hamilton, Shannon L. Maude, Rakesh Awasthi, Abhijit Chakraborty, Theodore W. Laetsch, Carl H. June, Stephan A. Grupp, Lori Tomassian, Keith J. August, Michael A. Pulsipher, Bruce L. Levine, Patricia A. Wood, John E. Levine, Mimi Leung, Edward Waldron, Karen Thudium Mueller, Denise Sickert, Michael Boyer
Publikováno v:
Clinical Lymphoma Myeloma and Leukemia. 17:S261-S262
Autor:
Denise Sickert, Christophe Zickler, Barbara Winkler, Francois Legay, Annette Zaar, Edwige Chokote, Kerstin Kroeger, Jean-Michel Grenet
Publikováno v:
Journal of Immunological Methods. 334:29-36
Detection of anti-drug antibodies (ADA) can be difficult, if not impossible, in the presence of drug in the sample. This is a particular concern with therapeutic monoclonal antibodies (mAbs), which have typically longer half-lives than other proteins