Zobrazeno 1 - 10
of 68
pro vyhledávání: '"Denise S Fernandez-Twinn"'
Autor:
Laura Dearden, Isadora C Furigo, Lucas C Pantaleão, L W P Wong, Denise S Fernandez-Twinn, Juliana de Almeida-Faria, Katherine A Kentistou, Maria V Carreira, Guillaume Bidault, Antonio Vidal-Puig, Ken K Ong, John R B Perry, Jose Donato, Susan E Ozanne
Publikováno v:
PLoS Biology, Vol 22, Iss 6, p e3002641 (2024)
In utero exposure to maternal obesity programs increased obesity risk. Animal models show that programmed offspring obesity is preceded by hyperphagia, but the mechanisms that mediate these changes are unknown. Using a mouse model of maternal obesity
Externí odkaz:
https://doaj.org/article/ab9fe1aaf89243808133bb36842e17d9
Autor:
Lucas C Pantaleão, Isabella Inzani, Samuel Furse, Elena Loche, Antonia Hufnagel, Thomas Ashmore, Heather L Blackmore, Benjamin Jenkins, Asha A M Carpenter, Ania Wilczynska, Martin Bushell, Albert Koulman, Denise S Fernandez-Twinn, Susan E Ozanne
Publikováno v:
eLife, Vol 11 (2022)
Maternal obesity during pregnancy has immediate and long-term detrimental effects on the offspring heart. In this study, we characterized the cardiac and circulatory lipid profiles in late gestation E18.5 fetuses of diet-induced obese pregnant mice a
Externí odkaz:
https://doaj.org/article/a87a0340baca416d87bef9384d650677
Autor:
Ionel Sandovici, Denise S. Fernandez-Twinn, Niamh Campbell, Wendy N. Cooper, Yoichi Sekita, Ilona Zvetkova, David Ferland-McCollough, Haydn M. Prosser, Lila M. Oyama, Lucas C. Pantaleão, Danilo Cimadomo, Karina Barbosa de Queiroz, Cecilia S.K. Cheuk, Nicola M. Smith, Richard G. Kay, Robin Antrobus, Katharina Hoelle, Marcella K.L. Ma, Noel H. Smith, Stefan H. Geyer, Lukas F. Reissig, Wolfgang J. Weninger, Kenneth Siddle, Anne E. Willis, Brian Y.H. Lam, Martin Bushell, Susan E. Ozanne, Miguel Constância
Publikováno v:
Cell Reports, Vol 43, Iss 9, Pp 114750- (2024)
Summary: Mir483 is a conserved and highly expressed microRNA in placental mammals, embedded within the Igf2 gene. Its expression is dysregulated in a number of human diseases, including metabolic disorders and certain cancers. Here, we investigate th
Externí odkaz:
https://doaj.org/article/abbc32c9c19d41bf953422abe96dc435
Autor:
Samuel Furse, Denise S. Fernandez-Twinn, Jessica H. Beeson, Davide Chiarugi, Susan E. Ozanne, Albert Koulman
Publikováno v:
Nutrition & Diabetes, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract Background Gestational diabetes is associated with increased risk of type 2 diabetes mellitus and cardiovascular disease for the mother in the decade after delivery. However, the molecular mechanisms that drive these effects are unknown. Rec
Externí odkaz:
https://doaj.org/article/e4d6352846024f0098ef7a1ae2c28d9f
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 14, p 7452 (2021)
The aim of the current study was to test the hypothesis that maternal lipid metabolism was modulated during normal pregnancy and that these modulations are altered in gestational diabetes mellitus (GDM). We tested this hypothesis using an established
Externí odkaz:
https://doaj.org/article/40ae4c69ca874432b8a1dbcb9e1ae3b1
Autor:
Josca M. Schoonejans, Heather L. Blackmore, Thomas J. Ashmore, Catherine E. Aiken, Denise S. Fernandez-Twinn, Susan E. Ozanne
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 15, p 8104 (2021)
Background: Metformin is commonly used to treat gestational diabetes mellitus. This study investigated the effect of maternal metformin intervention during obese glucose-intolerant pregnancy on the gonadal white adipose tissue (WAT) of 8-week-old mal
Externí odkaz:
https://doaj.org/article/9b59f51ca9104b268e47df0708017ac2
Publikováno v:
Journal of Endocrinology. 253:R47-R63
Obesity and gestational diabetes during pregnancy have multiple short- and long-term consequences for both mother and child. One common feature of pregnancies complicated by maternal obesity and gestational diabetes is maternal hyperinsulinaemia, whi
Autor:
Ionel Sandovici, Denise S. Fernandez-Twinn, Niamh Campbell, Wendy N. Cooper, Yoichi Sekita, Ilona Zvetkova, David Ferland-McCollough, Haydn M. Prosser, Lila M. Oyama, Danilo Cimadomo, Karina Barbosa de Queiroz, Cecilia S.K. Cheuk, Nicola M. Smith, Richard G. Kay, Katharina Hoelle, Noel H. Smith, Stefan H. Geyer, Lukas F. Reissig, Wolfgang J. Weninger, Kenneth Siddle, Anne E. Willis, Martin Bushell, Susan E. Ozanne, Miguel Constância
Mir483 is a conserved and highly expressed microRNA in placental mammals, embedded within the Igf2 gene. Here, we uncover the control mechanisms and physiological functions of Mir483 in vivo, by generating constitutive loss-of-function and over-expre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a46e279bb69b26d85a948cbb47f5772a
https://doi.org/10.1101/2022.09.09.507324
https://doi.org/10.1101/2022.09.09.507324
Autor:
Asha A. M. Carpenter, Lucas Carminatti Pantaleão, Thomas Prates Ong, Robin Antrobus, Elena Loche, Laura C. Kusinski, Susan E. Ozanne, Denise S. Fernandez-Twinn, Thomas J. Ashmore, Daniella Duque-Guimarães, Juliana de Almeida-Faria, Martin Bushell
Publikováno v:
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Diabetologia
Universidade de São Paulo (USP)
instacron:USP
Diabetologia
Aims/hypothesis Levels of the microRNA (miRNA) miR-126-3p are programmed cell-autonomously in visceral adipose tissue of adult offspring born to obese female C57BL/6J mice. The spectrum of miR-126-3p targets and thus the consequences of its dysregula
Autor:
Catherine E. Aiken, Susan E. Ozanne, Jane L. Tarry-Adkins, Laura Dearden, Denise S. Fernandez-Twinn
Publikováno v:
Gerontology. 67:233-242
Introduction: Due to increasing lifespan, global aging rates are rising rapidly and age-associated diseases are increasing. To ensure that health span is concomitant with life span, a greater understanding of cellular mechanisms of aging is important