Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Denise Ragusa"'
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-15 (2024)
Abstract The identification of clinically-relevant biomarkers is of upmost importance for the management of cancer, from diagnosis to treatment choices. We performed a pan-cancer analysis of the mitotic checkpoint budding uninhibited by benzimidazole
Externí odkaz:
https://doaj.org/article/5282491e834d41238917e4dcb7e66885
Autor:
Denise Ragusa, Paola Vagnarelli
Publikováno v:
Frontiers in Genetics, Vol 14 (2023)
Histone variants, which generally differ in few amino acid residues, can replace core histones (H1, H2A, H2B, and H3) to confer specific structural and functional features to regulate cellular functions. In addition to their role in DNA packaging, hi
Externí odkaz:
https://doaj.org/article/795bf6d0d45048bfb7147d87b5b4a460
Autor:
Elisa Garimberti, Concetta Federico, Denise Ragusa, Francesca Bruno, Salvatore Saccone, Joanna Mary Bridger, Sabrina Tosi
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 4, p 2377 (2024)
Chromosomal rearrangements have been shown to alter genome organization, consequently having an impact on gene expression. Studies on certain types of leukemia have shown that gene expression can be exacerbated by the altered nuclear positioning of f
Externí odkaz:
https://doaj.org/article/f7b40dc630094e28817b5b8b94c2c35f
Autor:
Denise Ragusa, Ylenia Cicirò, Concetta Federico, Salvatore Saccone, Francesca Bruno, Reza Saeedi, Cristina Sisu, Cristina Pina, Arturo Sala, Sabrina Tosi
Publikováno v:
Oncogenesis, Vol 11, Iss 1, Pp 1-7 (2022)
Abstract Acute myeloid leukaemia carrying the translocation t(7;12)(q36;p13) is an adverse-risk leukaemia uniquely observed in infants. Despite constituting up to 30% of cases in under 2-year-olds, it remains poorly understood. Known molecular featur
Externí odkaz:
https://doaj.org/article/5e65c05896734882813936b8b25d5ac4
Publikováno v:
Cells, Vol 11, Iss 22, p 3577 (2022)
The identification of diagnostic and prognostic biomarkers is a major objective in improving clinical outcomes in cancer, which has been facilitated by the availability of high-throughput gene expression data. A growing interest in non-coding genomic
Externí odkaz:
https://doaj.org/article/36c23c3945a24da08394a4bac8d9be64
Autor:
Concetta Federico, Francesca Bruno, Denise Ragusa, Craig S. Clements, Desiree Brancato, Marianne P. Henry, Joanna M. Bridger, Sabrina Tosi, Salvatore Saccone
Publikováno v:
Cancers, Vol 13, Iss 22, p 5860 (2021)
The last decade has seen significant progress in understanding how the genome is organized spatially within interphase nuclei. Recent analyses have confirmed earlier molecular cytogenetic studies on chromosome positioning within interphase nuclei and
Externí odkaz:
https://doaj.org/article/28e2f2c3cdeb4c978b1d450bad5ca58b
Publikováno v:
Genes & Nutrition, Vol 12, Iss 1, Pp 1-15 (2017)
Abstract Background Folic acid and its derivates, known as folates, are chemoprotective micronutrients of great interest because of their essential role in the maintenance of health and genomic integrity. The supplementation of folic acid during preg
Externí odkaz:
https://doaj.org/article/c5c73e38c44545c5826c5d7acbf5dfd9
Autor:
Gesualda M. Gulino, Francesca Bruno, Valentina Sturiale, Desiree Brancato, Denise Ragusa, Sabrina Tosi, Salvatore Saccone, Concetta Federico
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 5, p 2338 (2021)
Fluorescence in situ hybridization (FISH) and Hi-C methods are largely used to investigate the three-dimensional organization of the genome in the cell nucleus and are applied here to study the organization of genes (LMBR1, NOM1, MNX1, UBE3C, PTPRN2)
Externí odkaz:
https://doaj.org/article/10a10c7988f4406a9afc5dfb660fba53
Publikováno v:
Cells, Vol 8, Iss 11, p 1341 (2019)
The MLL (mixed-lineage leukemia) gene, located on chromosome 11q23, is involved in chromosomal translocations in a subtype of acute leukemia, which represents approximately 10% of acute lymphoblastic leukemia and 2.8% of acute myeloid leukemia cases.
Externí odkaz:
https://doaj.org/article/5467738591e6455799c8b2591d8b7a23
Autor:
Concetta Federico, Temitayo Owoka, Denise Ragusa, Valentina Sturiale, Domenica Caponnetto, Claudia Giovanna Leotta, Francesca Bruno, Helen A. Foster, Silvia Rigamonti, Giovanni Giudici, Giovanni Cazzaniga, Joanna M. Bridger, Cristina Sisu, Salvatore Saccone, Sabrina Tosi
Publikováno v:
Cancers, Vol 11, Iss 4, p 585 (2019)
The radial spatial positioning of individual gene loci within interphase nuclei has been associated with up- and downregulation of their expression. In cancer, the genome organization may become disturbed due to chromosomal abnormalities, such as tra
Externí odkaz:
https://doaj.org/article/9671d82545ea4b61bebd9b2e0a2da148