Výsledky vyhledávání - "Denise M.O. Ramirez"

Endogenous pathology in tauopathy mice progresses via brain networks

Autor: Denise M.O. Ramirez, Jennifer D. Whitesell, Nikhil Bhagwat, Talitha L. Thomas, Apoorva D. Ajay, Ariana Nawaby, Benoît Delatour, Sylvie Bay, Pierre LaFaye, Joseph E. Knox, Julie A. Harris, Julian P. Meeks, Marc I. Diamond

Publikováno v: bioRxiv

This archive contains the data and code used for the analyses in the manuscript: “Endogenous pathology in tauopathy mice progresses via brain networks”. One-Sentence Summary: Whole brain imaging of tau deposition reveals retrograde-dominant netwo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::703dbe6e8447c42eb34d23fa1ecc442e

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Establishment of patient-derived organoid models of lower-grade glioma

Autor: Timothy E. Richardson, Gao Zhang, Joseph Buehler, William H. Hicks, Michael M Levitt, Milan R. Savani, Toral R. Patel, Cylaina E. Bird, David M. Ashley, Lauren C. Gattie, Tomas Garzon-Muvdi, Kimmo J. Hatanpaa, Denise M.O. Ramirez, Alex C. Sternisha, Wenhao Li, Kalil G. Abdullah, Samuel L. Barnett, Samuel K. McBrayer, Yi Xiao

Publikováno v: Neuro-Oncology. 24:612-623

Background Historically, creating patient-derived models of lower-grade glioma (LGG) has been challenging, contributing to few experimental platforms that support laboratory-based investigations of this disease. Although organoid modeling approaches

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7837cbb159ea166f5ea43bc85b50f07e
https://doi.org/10.1093/neuonc/noab273

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B cells migrate into remote brain areas and support neurogenesis and functional recovery after focal stroke in mice

Autor: Amelia J. Eisch, Erik J. Plautz, Monica A. Benson, Sarah E. Latchney, Julian P. Meeks, Cody W. Whoolery, Mark P. Goldberg, Apoorva D. Ajay, Ann M. Stowe, Vanessa O. Torres, Sterling B. Ortega, Nancy L. Monson, Ibrahim Noorbhai, Uma Maheswari Selvaraj, Katie Poinsatte, Anouk Meeuwissen, Denise M.O. Ramirez, Xiangmei Kong

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America

Significance Neuroinflammation occurs immediately after stroke onset in the ischemic infarct, but whether neuroinflammation occurs in remote regions supporting plasticity and functional recovery remains unknown. We used advanced imaging to quantify w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eaeb37529d0cb03010df30ffb9ec6ebe
http://europepmc.org/articles/PMC7060723

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Milk Exosomes Cross the Blood-Brain Barrier in Murine Cerebral Cortex Endothelial Cells and Promote Dendritic Complexity in the Hippocampus and Brain Function in C57BL/6J Mice

Autor: Janos Zempleni, Peng Ji, Haluk Dogan, Wenhao Li, Ezra Mutai, Fang Zhou, Sonal Sukreet, Juan Cui, Pearl Ebea, Shya Navazesh, Denise M.O. Ramirez

BackgroundHuman milk contains large amounts of exosomes (MEs) and their regulatory microRNA cargos, whereas infant formulas contain only trace amounts of MEs and microRNAs. Breastfeeding has been implicated in optimal brain development but experiment

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::acec3a977a4ba4a3578034cad6e33f79
https://doi.org/10.1101/2021.11.24.469889

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Gross and Histologic Anatomy of the Pelvic Ureter

Autor: Alexandra Spirtos, Denise M.O. Ramirez, Lindsey A. Jackson, Marlene M. Corton, Rebecca Pedersen, Kelley Carrick

Publikováno v: Obstetrics & Gynecology. 133:896-904

Objective To further evaluate relationships of the pelvic ureter to clinically relevant structures and to characterize the anatomy, histology, and nerve density of the distal ureter. Methods In this observational cadaveric study, 35 female cadavers w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5592046ef58f47024f9d76fe9610afd8
https://doi.org/10.1097/aog.0000000000003221

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Abstract P367: Brain-Wide Quantification of Amyloid in Transgenic Mice Using Volumetric Imaging and Automated Image Analysis

Autor: Lauren L Schneider, Erik K Plautz, Mark P. Goldberg, Apoorva D. Ajay, Anaiza S Irani, Denise M.O. Ramirez, Xiangmei Kong

Publikováno v: Stroke. 52

Localizing and quantifying amyloid in three dimensions furthers understanding of spatial patterns of amyloid deposition and disease progression in experimental models of cerebral amyloid angiopathy (CAA). Serial two-photon tomography (STPT) is ideal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::826eea080e4567c12771a0a463b28fa3
https://doi.org/10.1161/str.52.suppl_1.p367

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Abstract 121: Visualization and Quantification of Post-Stroke Neural Connectivity in Mice Using Serial Two-Photon Tomography

Autor: Ann M. Stowe, Dene M Betz, Katherine Poinsatte, Denise M.O. Ramirez, Xiangmei Kong, Mark P. Goldberg, Julian P. Meeks, Erik J. Plautz, Apoorva D. Ajay

Publikováno v: Stroke. 51

Background: It is a challenge to characterize post-stroke changes in neural connectivity at microscopic scale across the entire rodent brain. Serial two-photon tomography (STPT) is an advanced laser-scanning microscopy technique which collects serial

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ff6bc6673234e99e4f5c9266b9427d3d
https://doi.org/10.1161/str.51.suppl_1.121

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Cell-Specific Loss of SNAP25 from Cortical Projection Neurons Allows Normal Development but Causes Subsequent Neurodegeneration

Autor: Helen C. Christian, Ege T. Kavalali, Zoltán Molnár, Eleanor Grant, Shuichi Hayashi, Denise M.O. Ramirez, Anna Hoerder-Suabedissen, Alexander Jeans, Kim K.V. Korrell, Michael Wilson

Publikováno v: Cereb Cortex

Synaptosomal associated protein 25 kDa (SNAP25) is an essential component of the SNARE complex regulating synaptic vesicle fusion. SNAP25 deficiency has been implicated in a variety of cognitive disorders. We ablated SNAP25 from selected neuronal pop

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https://doi.org/10.1093/cercor/bhy127

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