New susceptibility loci associated with kidney disease in type 1 diabetes.

Autor: Niina Sandholm, Rany M Salem, Amy Jayne McKnight, Eoin P Brennan, Carol Forsblom, Tamara Isakova, Gareth J McKay, Winfred W Williams, Denise M Sadlier, Ville-Petteri Mäkinen, Elizabeth J Swan, Cameron Palmer, Andrew P Boright, Emma Ahlqvist, Harshal A Deshmukh, Benjamin J Keller, Huateng Huang, Aila J Ahola, Emma Fagerholm, Daniel Gordin, Valma Harjutsalo, Bing He, Outi Heikkilä, Kustaa Hietala, Janne Kytö, Päivi Lahermo, Markku Lehto, Raija Lithovius, Anne-May Osterholm, Maija Parkkonen, Janne Pitkäniemi, Milla Rosengård-Bärlund, Markku Saraheimo, Cinzia Sarti, Jenny Söderlund, Aino Soro-Paavonen, Anna Syreeni, Lena M Thorn, Heikki Tikkanen, Nina Tolonen, Karl Tryggvason, Jaakko Tuomilehto, Johan Wadén, Geoffrey V Gill, Sarah Prior, Candace Guiducci, Daniel B Mirel, Andrew Taylor, S Mohsen Hosseini, DCCT/EDIC Research Group, Hans-Henrik Parving, Peter Rossing, Lise Tarnow, Claes Ladenvall, François Alhenc-Gelas, Pierre Lefebvre, Vincent Rigalleau, Ronan Roussel, David-Alexandre Tregouet, Anna Maestroni, Silvia Maestroni, Henrik Falhammar, Tianwei Gu, Anna Möllsten, Danut Cimponeriu, Mihai Ioana, Maria Mota, Eugen Mota, Cristian Serafinceanu, Monica Stavarachi, Robert L Hanson, Robert G Nelson, Matthias Kretzler, Helen M Colhoun, Nicolae Mircea Panduru, Harvest F Gu, Kerstin Brismar, Gianpaolo Zerbini, Samy Hadjadj, Michel Marre, Leif Groop, Maria Lajer, Shelley B Bull, Daryl Waggott, Andrew D Paterson, David A Savage, Stephen C Bain, Finian Martin, Joel N Hirschhorn, Catherine Godson, Jose C Florez, Per-Henrik Groop, Alexander P Maxwell

Publikováno v: PLoS Genetics, Vol 8, Iss 9, p e1002921 (2012)

Diabetic kidney disease, or diabetic nephropathy (DN), is a major complication of diabetes and the leading cause of end-stage renal disease (ESRD) that requires dialysis treatment or kidney transplantation. In addition to the decrease in the quality

Externí odkaz: https://doaj.org/article/818e5a61debb4667aafbe14358bd9b2a

The effect of obesity on acute kidney injury after cardiac surgery

Autor: Anna Marie Murphy, Denise M. Sadlier, John S Byrne, John Hurley, Katie E O'Sullivan, Amy Hudson

Publikováno v: The Journal of Thoracic and Cardiovascular Surgery. 150:1622-1628

Objective Postoperative acute kidney injury is a frequent and serious consequence of cardiac surgery. We undertook to investigate the association of obesity and the risk of acute kidney injury development after cardiac surgery. Methods A total of 432

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ff1b5ec5ca4e334813f70dddaab816e
https://doi.org/10.1016/j.jtcvs.2015.08.082

The Genetics of Diabetic Nephropathy

Autor: Eoin P. Brennan, Finian Martin, Caitriona McEvoy, Denise M. Sadlier, Catherine Godson

Publikováno v: Genes
Genes, Vol 4, Iss 4, Pp 596-619 (2013)

Up to 40% of patients with type 1 and type 2 diabetes will develop diabetic nephropathy (DN), resulting in chronic kidney disease and potential organ failure. There is evidence for a heritable genetic susceptibility to DN, but despite intensive resea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7444c36813a50736b37f2f49db916389
http://europepmc.org/articles/PMC3927570

Lipoxins Attenuate Renal Fibrosis by Inducing let-7c and Suppressing TGFβR1

Autor: Karen A. Nolan, Patrick J. Guiry, Alexander P. Maxwell, David A. Savage, Catherine Godson, Eoin P. Brennan, Finian Martin, Denise M. Sadlier, Madeline Murphy, Emma Börgeson, Syed Tasadaque Ali-Shah, Neil G. Docherty, Oisín S. Gough, Caitriona McEvoy, Debra F. Higgins

Publikováno v: Journal of the American Society of Nephrology. 24:627-637

Lipoxins, which are endogenously produced lipid mediators, promote the resolution of inflammation, and may inhibit fibrosis, suggesting a possible role in modulating renal disease. Here, lipoxin A4 (LXA4) attenuated TGF-β1-induced expression of fibr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8b61b0ed4edd610755741764dd04cb4
https://doi.org/10.1681/asn.2012060550

Early viral and peripheral blood mononuclear cell responses to pegylated interferon and ribavirin treatment: the first 24 h

Autor: Emma J. Devitt, John Crowe, Caroline Walsh, Matthew W. Lawless, John A. Browne, Denise M. Sadlier

Publikováno v: European Journal of Gastroenterology & Hepatology. 22:1211-1220

OBJECTIVES This study explored gene expression differences in predicting response to pegylated interferon (IFN-PEG) and ribavirin (RBV) in hepatitis C infection. Current treatment for hepatitis C virus (HCV) with IFN-PEG alpha-2a/b and RBV is an expe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::760b8e037aec7830eb029817c0b1444b
https://doi.org/10.1097/meg.0b013e32833caf7b