Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Denise M. Drotar"'
Autor:
Denise M. Drotar, Ana Karen Mojica-Avila, Drew T. Bloss, Christian M. Cohrs, Cameron T. Manson, Amanda L. Posgai, MacKenzie D. Williams, Maigan A. Brusko, Edward A. Phelps, Clive H. Wasserfall, Stephan Speier, Mark A. Atkinson
Publikováno v:
Cell Reports, Vol 43, Iss 6, Pp 114346- (2024)
Summary: Histopathological heterogeneity in the human pancreas is well documented; however, functional evidence at the tissue level is scarce. Herein, we investigate in situ glucose-stimulated islet and carbachol-stimulated acinar cell secretion acro
Externí odkaz:
https://doaj.org/article/fcfd2fb1042a446182c1c09a0ce0ffd8
Autor:
Christian M. Cohrs, Julia K. Panzer, Denise M. Drotar, Stephen J. Enos, Nicole Kipke, Chunguang Chen, Robert Bozsak, Eyke Schöniger, Florian Ehehalt, Marius Distler, Ana Brennand, Stefan R. Bornstein, Jürgen Weitz, Michele Solimena, Stephan Speier
Publikováno v:
Cell Reports, Vol 31, Iss 1, Pp - (2020)
Summary: Type 2 diabetes is characterized by peripheral insulin resistance and insufficient insulin release from pancreatic islet β cells. However, the role and sequence of β cell dysfunction and mass loss for reduced insulin levels in type 2 diabe
Externí odkaz:
https://doaj.org/article/74611d8ea8d3455cb3cb7f860abbdb27
Autor:
MOLLIE HUBER, MARJAN SLAK RUPNIK, DENISE M. DROTAR, HELMUT HILLER, SR., MARIA BEERY, IRINA KUSMARTSEVA, MARK A. ATKINSON, EDWARD PHELPS, CLAYTON E. MATHEWS
Publikováno v:
Diabetes. 71
Features of type 1 diabetes (T1D) include loss of first-phase insulin secretion in response to glucose, declining c-peptide, and glucose intolerance; indicating β cell dysfunction. Here, we investigate the mechanisms of this dysfunction with the hyp
Autor:
Stephen J. Enos, Mollie K. Huber, Joana Almaça, Jorge Santini, Ricardo L. Pastori, Mirza Muhammad Fahd Qadir, Alberto Pugliese, Christian M. Cohrs, Helmut Hiller, Stephan Speier, Maria Beery, Julia K. Panzer, Juan Domínguez-Bendala, Mark A. Atkinson, Alejandro Caicedo, Edward A. Phelps, Sirlene Cechin, John R. Weitz, Irina Kusmartseva, Denise M. Drotar
Publikováno v:
JCI insight 5:134525 (2020)
JCI Insight
JCI Insight
In type 1 diabetes (T1D), autoimmune destruction of pancreatic beta cells leads to insulin deficiency and loss of glycemic control. However, knowledge about human pancreas pathophysiology in T1D remains incomplete. To address this limitation, we esta
Autor:
Michele Solimena, Ana Brennand, Julia K. Panzer, Nicole Kipke, Marius Distler, Robert Bozsak, Christian M. Cohrs, Stephen J. Enos, Denise M. Drotar, Stefan R. Bornstein, Stephan Speier, Eyke Schöniger, Florian Ehehalt, Chunguang Chen, Jürgen Weitz
Publikováno v:
Cell Reports
Cell Reports, Vol 31, Iss 1, Pp-(2020)
Cell Rep. 31:107469 (2020)
Cell Reports, Vol 31, Iss 1, Pp-(2020)
Cell Rep. 31:107469 (2020)
Summary: Type 2 diabetes is characterized by peripheral insulin resistance and insufficient insulin release from pancreatic islet β cells. However, the role and sequence of β cell dysfunction and mass loss for reduced insulin levels in type 2 diabe