Výsledky vyhledávání - "Denise L. Holzle"

Binding Ensemble Profiling with Photoaffinity Labeling (BEProFL) Approach: Mapping the Binding Poses of HDAC8 Inhibitors

Autor: Denise L. Holzle, Pavel A. Petukhov, Subash Velaparthi, Bai He, Chris Pennington, Richard B. van Breemen, Aruna Mahesh, Sylvie Y. Blond, Michael Brunsteiner, Gilles Pieffet

Publikováno v: Journal of Medicinal Chemistry. 52:7003-7013

A binding ensemble profiling with (f)photoaffinity labeling (BEProFL) approach that utilizes photolabeling of HDAC8 with a probe containing a UV-activated aromatic azide, mapping of the covalent modifications by liquid chromatography-tandem mass spec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02204d7e13dd2a07ea7ab49d96ebd1a0
https://doi.org/10.1021/jm9005077

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Use of molecular modeling, docking, and 3D-QSAR studies for the determination of the binding mode of benzofuran-3-yl-(indol-3-yl)maleimides as GSK-3β inhibitors

Autor: Alan P. Kozikowski, Andrew D. Mesecar, Sylvie Y. Blond, Denise L. Holzle, Franck Gallier, Irina N. Gaisina, Ki Hwan Kim

Publikováno v: Journal of Molecular Modeling. 15:1463-1479

Molecular modeling and docking studies along with three-dimensional quantitative structure relationships (3D-QSAR) studies have been used to determine the correct binding mode of glycogen synthase kinase 3beta (GSK-3beta) inhibitors. The approaches o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::69fc441842085d7b1cc537d840507c81
https://doi.org/10.1007/s00894-009-0498-x

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From a Natural Product Lead to the Identification of Potent and Selective Benzofuran-3-yl-(indol-3-yl)maleimides as Glycogen Synthase Kinase 3β Inhibitors That Suppress Proliferation and Survival of Pancreatic Cancer Cells

Autor: Alan P. Kozikowski, Sylvie Y. Blond, Franck Gallier, Andrei V. Ougolkov, Songpo Guo, Daniel D. Billadeau, Irina N. Gaisina, Toru Kurome, Denise L. Holzle, Doris N. Luchini, Ki Hwan Kim

Publikováno v: Journal of Medicinal Chemistry. 52:1853-1863

Recent studies have demonstrated that glycogen synthase kinase 3beta (GSK-3beta) is overexpressed in human colon and pancreatic carcinomas, contributing to cancer cell proliferation and survival. Here, we report the design, synthesis, and biological

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8b5e73cfb9faf8350c5e0a6466df322
https://doi.org/10.1021/jm801317h

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Design, synthesis, docking, and biological evaluation of novel diazide-containing isoxazole- and pyrazole-based histone deacetylase probes

Autor: Denise L. Holzle, Pavel A. Petukhov, He Bai, Subash Velaparthi, Michael Brunsteiner, Sylvie Y. Blond, Raghupathi Neelarapu

Publikováno v: Journal of medicinal chemistry. 54(13)

The design, synthesis, docking, and biological evaluation of novel potent HDAC3 and HDAC8 isoxazole- and pyrazole-based diazide probes suitable for binding ensemble profiling with photoaffinity labeling (BEProFL) experiments in cells is described. Bo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69c8398e80d5080bf2c1d0ea5938fd58
https://pubmed.ncbi.nlm.nih.gov/21548582

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Akademický článek

Binding Ensemble Profiling with Photoaffinity Labeling (BEProFL) Approach: Mapping the Binding Poses of HDAC8 Inhibitors.

Autor: Bai He, Subash Velaparthi, Gilles Pieffet, Chris Pennington, Aruna Mahesh, Denise L. Holzle, Michael Brunsteiner, Richard van Breemen, Sylvie Y. Blond, Pavel A. Petukhov

Publikováno v: Journal of Medicinal Chemistry; Nov2009, Vol. 52 Issue 22, p7003-7013, 11p

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