Výsledky vyhledávání - "Denise Kavanaugh"

Immunization With Mutantp53- andK-ras–Derived Peptides in Cancer Patients: Immune Response and Clinical Outcome

Autor: Michael Stipanov, Jay A. Berzofsky, M. Charles Smith, I. Frank Ciernik, Denise Kavanaugh, Charley Carter, Elizabeth J. Read, David Contois, Morris I. Kelsey, Sorena Nadaf, Burkhardt Seifert, Lois E. Top, John D. Minna, C. David Pendleton, Bruce E. Johnson, Michael J. Kelley, David P. Carbone, Jay Greenblatt, V. Ellen Maher

Publikováno v: Journal of Clinical Oncology. 23:5099-5107

PurposeTo determine the ability to induce tumor-specific immunity with individual mutant K-ras–or p53-derived peptides and to monitor clinical outcome.Patients and MethodsPatients in varying stages of disease underwent genetic analysis for mutation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49d8c32f2572e9746b8ddbdd0c2a8991
https://doi.org/10.1200/jco.2005.03.158

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Production of vascular endothelial growth factor by human tumors inhibits the functional maturation of dendritic cells

Autor: Hailei L. Chen, Dmitry I. Gabrilovich, David P. Carbone, Geralyn M. Meny, Sorena Nadaf, H. Thomas Cunningham, Khaled R. Girgis, Denise Kavanaugh

Publikováno v: Nature Medicine. 2:1096-1103

Inadequate presentation of tumor antigens by host professional antigen-presenting cells (APCs), including dendritic cells (DCs), is one potential mechanism for the escape of tumors from the host immune system. Here, we show that human cancer cell lin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a55dc23bb378080e0277a31a78a23f2f
https://doi.org/10.1038/nm1096-1096

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IMMUNOLOGIC DYSFUNCTION IN CANCER

Autor: Denise Kavanaugh, David P. Carbone

Publikováno v: Hematology/Oncology Clinics of North America. 10:927-952

The interactions between the tumor and its host are complex, and many aspects of the immune system appear to be adversely affected directly or indirectly by the presence of the tumor. Virtually all of the processes involved in immune induction and ac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4aa705ad39e552fb4ac63fd8fdca30e9
https://doi.org/10.1016/s0889-8588(05)70376-2

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A higher plant enzyme exhibiting broad acceptance of stereoisomers

Autor: Denise Kavanaugh, Gerald A. Rosenthal, Milan A. Berge

Publikováno v: Plant physiology. 94(1)

An arginase, purified from the leaf of the jack bean, Canavalia ensiformis, can effectively hydrolyze both l- and d-arginine. Arginases, examined from a number of other plant and animal sources, exhibit marked substrate stereospecificity and fail to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d1c5404be5b8a8c0cbeb831bfa906b1
https://pubmed.ncbi.nlm.nih.gov/16667720

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