Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Denise J. Tsagris"'
Autor:
Nathalie Bouloc, Kristian Birchall, Andy Merritt, Keith H. Ansell, David A. Baker, Paul W. Bowyer, David Whalley, Simon A. Osborne, Denise J. Tsagris, P.J. Coombs, Ela Smiljanic-Hurley, Jonathan M. Large, Lindsay B. Stewart, Mary C. Wheldon, Catherine A. Kettleborough
Publikováno v:
Bioorganic & Medicinal Chemistry Letters
Graphical abstract
Development of a class of bicyclic inhibitors of the Plasmodium falciparum cyclic GMP-dependent protein kinase (PfPKG), starting from known compounds with activity against a related parasite PKG orthologue, is reported. Examin
Development of a class of bicyclic inhibitors of the Plasmodium falciparum cyclic GMP-dependent protein kinase (PfPKG), starting from known compounds with activity against a related parasite PKG orthologue, is reported. Examin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a01a5f293ace057b567da68eeb378c47
https://doi.org/10.1016/j.bmcl.2018.11.039
https://doi.org/10.1016/j.bmcl.2018.11.039
Autor:
Nathalie Bouloc, Paul W. Bowyer, Keith H. Ansell, Jonathan M. Large, Kristian Birchall, Catherine A. Kettleborough, Denise J. Tsagris, David A. Baker, Ela Smiljanic-Hurley, Mary C. Wheldon, Lindsay B. Stewart, David Whalley, Simon A. Osborne, Andy Merritt
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 28:3168-3173
A series of trisubstituted thiazoles have been identified as potent inhibitors of Plasmodium falciparum (Pf) cGMP-dependent protein kinase (PfPKG) through template hopping from known Eimeria PKG (EtPKG) inhibitors. The thiazole series has yielded com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49b91d780c2345c0f96aac2b5f0ee17a
https://doi.org/10.1016/j.bmcl.2018.08.028
https://doi.org/10.1016/j.bmcl.2018.08.028
Autor:
Dario R. Alessi, Kristian Birchall, Ela Smiljanic-Hurley, Alison Levy, Edward G. McIver, Denise J. Tsagris, Joanne Osborne, Stephen John Lewis, Debra L. Taylor
Publikováno v:
Bioorganicmedicinal chemistry letters. 29(4)
Parkinson's disease is a relatively common neurological disorder with incidence increasing with age. Present treatments merely alleviate the symptoms and do not alter the course of the disease, thus identification of disease modifying therapies repre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85ceb9c04ce3ece4e8597335904def25
https://pubmed.ncbi.nlm.nih.gov/30554956
https://pubmed.ncbi.nlm.nih.gov/30554956
Autor:
Catherine A. Kettleborough, Kristian Birchall, David Whalley, Nathalie Bouloc, Paul W. Bowyer, Keith H. Ansell, Lindsay B. Stewart, Jonathan M. Large, David A. Baker, Ela Smiljanic-Hurley, Mary C. Wheldon, Andy Merritt, P.J. Coombs, Denise J. Tsagris, Simon A. Osborne
Publikováno v:
Bioorganic & Medicinal Chemistry Letters
Graphical abstract
Focussed studies on imidazopyridine inhibitors of Plasmodium falciparum cyclic GMP-dependent protein kinase (PfPKG) have significantly advanced the series towards desirable in vitro property space. LLE-based approaches towards
Focussed studies on imidazopyridine inhibitors of Plasmodium falciparum cyclic GMP-dependent protein kinase (PfPKG) have significantly advanced the series towards desirable in vitro property space. LLE-based approaches towards
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9f9f3e44a380c2be3d4299d3f1cc6aa
https://doi.org/10.1016/j.bmcl.2019.08.014
https://doi.org/10.1016/j.bmcl.2019.08.014