Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Denise J. Cai"'
Autor:
Zachary T. Pennington, Alexa R. LaBanca, Patlapa Sompolpong, Shereen D. Abdel-Raheim, Bumjin Ko, Zoe Christenson Wick, Yu Feng, Zhe Dong, Taylor R. Francisco, Madeline E. Bacon, Lingxuan Chen, Sasha L. Fulton, Ian Maze, Tristan Shuman, Denise J. Cai
Publikováno v:
Cell Reports, Vol 43, Iss 11, Pp 114871- (2024)
Summary: Stress can have profound consequences on mental health. While much is known about the neural circuits supporting associative memories of stressful events, our understanding of the circuits underlying the non-associative impacts of stress, su
Externí odkaz:
https://doaj.org/article/8a2081e121f540ad9c755bfe4c392e22
Publikováno v:
Frontiers in Human Neuroscience, Vol 13 (2019)
Real-world memories involve the integration of multiple events across time, yet the mechanisms underlying this integration is unknown. Recent rodent studies show that distinct memories encoded within a few hours, but not several days, share a common
Externí odkaz:
https://doaj.org/article/cec5a5875e814ccc9fe175c7f77faf4c
Autor:
Zhe Dong, William Mau, Yu Feng, Zachary T Pennington, Lingxuan Chen, Yosif Zaki, Kanaka Rajan, Tristan Shuman, Daniel Aharoni, Denise J Cai
Publikováno v:
eLife, Vol 11 (2022)
Miniature microscopes have gained considerable traction for in vivo calcium imaging in freely behaving animals. However, extracting calcium signals from raw videos is a computationally complex problem and remains a bottleneck for many researchers uti
Externí odkaz:
https://doaj.org/article/5952920a702b47c081ead444addae62c
Autor:
Lingxuan Chen, Taylor R. Francisco, Austin M. Baggetta, Yosif Zaki, Steve Ramirez, Roger L. Clem, Tristan Shuman, Denise J. Cai
Publikováno v:
Neurobiology of Aging. 123:92-97
With the prevalence of age-related cognitive deficits on the rise, it is essential to identify cellular and circuit alterations that contribute to age-related memory impairment. Increased intrinsic neuronal excitability after learning is important fo
Publikováno v:
eLife, Vol 9 (2020)
While memories are often thought of as flashbacks to a previous experience, they do not simply conserve veridical representations of the past but must continually integrate new information to ensure survival in dynamic environments. Therefore, ‘dri
Externí odkaz:
https://doaj.org/article/605862363064401dbf9f1a42bcbe2cdc
Representational drift refers to the dynamic nature of neural representations in the brain despite the behavior being seemingly stable. Although drift has been observed in many different brain regions, the mechanisms underlying it are not known. Sinc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::631c500239e35b1ed3e61e6fad3400dc
http://hdl.handle.net/10044/1/103941
http://hdl.handle.net/10044/1/103941
Autor:
Romain Durand-de Cuttoli, Freddyson J. Martínez-Rivera, Long Li, Angélica Minier-Toribio, Zhe Dong, Denise J. Cai, Scott J. Russo, Eric J. Nestler, Brian M. Sweis
Economic stress can serve as a “second-hit” for those who already accumulated a history of adverse life experiences. How one recovers from a setback is a core feature of resilience but is seldom captured in animal studies. We challenged mice in a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4cbe75b8f393ba1bec8aa3eee91104c0
https://doi.org/10.1101/2023.03.19.533304
https://doi.org/10.1101/2023.03.19.533304
Autor:
Yosif Zaki, Zachary T. Pennington, Denisse Morales-Rodriguez, Taylor R. Francisco, Alexa R. LaBanca, Zhe Dong, Simon Carrillo Segura, Alcino J. Silva, Tristan Shuman, Andre Fenton, Kanaka Rajan, Denise J. Cai
Publikováno v:
bioRxiv
Memories are encoded in neural ensembles during learning and stabilized by post-learning reactivation. Integrating recent experiences into existing memories ensures that memories contain the most recently available information, but how neural ensembl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::facb758913cd2f41ba5800448ea731a5
https://doi.org/10.1101/2023.03.13.532469
https://doi.org/10.1101/2023.03.13.532469
Autor:
Zachary T. Pennington, Alexa R. LaBanca, Patlapa Sompolpong, Zoe Christenson Wick, Yu Feng, Zhe Dong, Taylor R. Francisco, Lingxuan Chen, Sasha L. Fulton, Ian Maze, Tristan Shuman, Denise J. Cai
Severe stress can produce multiple persistent changes in defensive behavior. While much is known about the circuits supporting stress-induced associative fear responses, how circuit plasticity supports the broader changes in defensive behavior observ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a4517d0fd7e1c98bc739a37e2198f418
https://doi.org/10.1101/2023.02.27.530077
https://doi.org/10.1101/2023.02.27.530077
Autor:
Behnam Javidfar, Wei-Dong Yao, Fatemeh Haghighi, M. Foo, C. P. Watkins, C. G. Hahn, Søren Heissel, H. L. Phillips, Schahram Akbarian, Sohit Miglani, Jennifer Blaze, Henrik Molina, B. Rostandy, Zachary T. Pennington, Albertas Navickas, Tao Pan, Hani Goodarzi, Denise J. Cai, Hanan Alwaseem, A. Plaza-Jennings, Sergio Espeso-Gil, Christopher D. Katanski, Hosseinali Asgharian
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Nature communications, vol 12, iss 1
Nature Communications
Nature communications, vol 12, iss 1
Nature Communications
Epitranscriptomic mechanisms linking tRNA function and the brain proteome to cognition and complex behaviors are not well described. Here, we report bi-directional changes in depression-related behaviors after genetic disruption of neuronal tRNA cyto