Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Denise G Teotico"'
Autor:
Denise G Teotico, Monica L Frazier, Feng Ding, Nikolay V Dokholyan, Brenda R S Temple, Matthew R Redinbo
Publikováno v:
PLoS Computational Biology, Vol 4, Iss 7, p e1000111 (2008)
Nuclear receptor ligand binding domains (LBDs) convert ligand binding events into changes in gene expression by recruiting transcriptional coregulators to a conserved activation function-2 (AF-2) surface. While most nuclear receptor LBDs form homo- o
Externí odkaz:
https://doaj.org/article/f1758556d4e849d491ec7f8883923860
Autor:
Haiyan Huang, Jeff L. Staudinger, Hao Li, Matthew R. Redinbo, Michael Sinz, Ganjam V. Kalpana, Sridhar Mani, Denise G. Teotico, Hongwei Wang, Sharyn D. Baker
Publikováno v:
Clinical Cancer Research. 13:2488-2495
Purpose: Variations in biotransformation and elimination of microtubule-binding drugs are a major cause of unpredictable side effects during cancer therapy. Because the orphan receptor, pregnenolone X-receptor (PXR), coordinately regulates the expres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::760a568ff270f0205ece64919c86003d
https://doi.org/10.1158/1078-0432.ccr-06-1592
https://doi.org/10.1158/1078-0432.ccr-06-1592
Autor:
Gabriel J. Rocklin, Kerim Babaoglu, Anthony M. Giannetti, Denise G. Teotico, Brian K. Shoichet, Rafaela Salgado Ferreira
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 106(18)
Fragment screens for new ligands have had wide success, notwithstanding their constraint to libraries of 1,000–10,000 molecules. Larger libraries would be addressable were molecular docking reliable for fragment screens, but this has not been widel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7dc07026c6e3ad9d8ee7d87f725dc7eb
https://pubmed.ncbi.nlm.nih.gov/19416920
https://pubmed.ncbi.nlm.nih.gov/19416920
Publikováno v:
Molecular pharmacology. 74(6)
Hops extracts are used to alleviate menopausal symptoms and as an alternative to hormone replacement therapy, but they can produce potentially harmful drug-drug interactions. The nuclear xenobiotic receptor pregnane X receptor (PXR) is promiscuously
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40592bdabe8c433bb36a19933a331b3a
https://pubmed.ncbi.nlm.nih.gov/18768384
https://pubmed.ncbi.nlm.nih.gov/18768384
Publikováno v:
Journal of computer-aided molecular design. 22(9)
The use of inaccurate scoring functions in docking algorithms may result in the selection of compounds with high predicted binding affinity that nevertheless are known experimentally not to bind to the target receptor. Such falsely predicted binders
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f4d42ae4afd59b7109da86b1464d7ee
https://pubmed.ncbi.nlm.nih.gov/18338225
https://pubmed.ncbi.nlm.nih.gov/18338225
Autor:
Jeff L. Staudinger, M. Zoeckler, Hongwei Wang, H. Huang, Matthew R. Redinbo, Michael Sinz, Sridhar Mani, Ganjam V. Kalpana, Joseph Locker, Denise G. Teotico
Publikováno v:
Oncogene. 26(2)
Individual variation in drug metabolism is a major cause of unpredictable side effects during therapy. Drug metabolism is controlled by a class of orphan nuclear receptors (NRs), which regulate expression of genes such as CYP (cytochrome)3A4 and MDR-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b557cd766657fa17a77d0bb3e09ecf1a
https://pubmed.ncbi.nlm.nih.gov/16819505
https://pubmed.ncbi.nlm.nih.gov/16819505
Publikováno v:
Molecular endocrinology (Baltimore, Md.). 19(12)
The nuclear receptor pregnane X receptor (PXR) plays a key but structurally enigmatic role in human biology. This ligand-regulated transcription factor responds to a diverse array of chemically distinct ligands, including many endogenous compounds an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2075bfe3cc14511b1e8f63ed50157769
https://pubmed.ncbi.nlm.nih.gov/15961506
https://pubmed.ncbi.nlm.nih.gov/15961506
Autor:
Feng Ding, Denise G. Teotico, Nikolay V. Dokholyan, Matthew R. Redinbo, Monica L. Frazier, Brenda Temple
Publikováno v:
PLoS Computational Biology, Vol 4, Iss 7, p e1000111 (2008)
PLoS Computational Biology
PLoS Computational Biology
Nuclear receptor ligand binding domains (LBDs) convert ligand binding events into changes in gene expression by recruiting transcriptional coregulators to a conserved activation function-2 (AF-2) surface. While most nuclear receptor LBDs form homo- o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fca2c648ba3d5ddc54f2fc1352e3712
https://doi.org/10.1371/journal.pcbi.1000111
https://doi.org/10.1371/journal.pcbi.1000111