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pro vyhledávání: '"Denise F. Happ"'
The Kynurenine Pathway Is Upregulated by Methyl-deficient Diet and Changes Are Averted by Probiotics
Autor:
Per Magne Ueland, Hussain M. Awwad, Giulia Treccani, Sandra Tillmann, Chad W. MacPherson, Denise F. Happ, Thomas A. Tompkins, Gregers Wegener, Rima Obeid, Juergen Geisel
Publikováno v:
Tillmann, S, Awwad, H M, MacPherson, C W, Happ, D F, Treccani, G, Geisel, J, Tompkins, T A, Ueland, P M, Wegener, G & Obeid, R 2021, ' The kynurenine pathway is upregulated by methyl-deficient diet and changes are averted by probiotics ', Molecular Nutrition & Food Research, vol. 65, no. 9, 2100078, pp. e2100078 . https://doi.org/10.1002/mnfr.202100078
Molecular Nutrition & Food Research
Molecular Nutrition & Food Research
Scope Probiotics exert immunomodulatory effects and may influence tryptophan metabolism in the host. Deficiency of nutrients related to C1 metabolism might stimulate inflammation by enhancing the kynurenine pathway. This study used Sprague Dawley rat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e6901d8260975ae41e28ff7bd8b3216
Publikováno v:
Happ, D F, Wegener, G & Tasker, R A 2021, ' Behavioral and histopathological consequences of transient ischemic stroke in the Flinders Sensitive Line rat, a genetic animal model of depression ', Brain Research, vol. 1771, 147648 . https://doi.org/10.1016/j.brainres.2021.147648
Patients with depression have an increased risk for stroke, higher mortality rates following stroke and worse functional outcomes among survivors. Preclinical studies may help to better understand the underlying mechanisms linking these two diseases,
Autor:
Sandra Tillmann, Juergen Geisel, Per F. Mikkelsen, Gregers Wegener, Denise F. Happ, Rima Obeid
Publikováno v:
Tillmann, S, Happ, D F, Mikkelsen, P F, Geisel, J, Wegener, G & Obeid, R 2019, ' Behavioral and metabolic effects of S-adenosylmethionine and imipramine in the Flinders Sensitive Line rat model of depression ', Behavioural Brain Research, vol. 364, pp. 274-280 . https://doi.org/10.1016/j.bbr.2019.02.011
Depression is associated with dysregulation of methyl group metabolism such as low S-adenosylmethionine (SAM). We previously reported that Flinders Sensitive Line (FSL) rats, an animal model of depression, had lower concentrations of liver SAM than t
Autor:
R. Andrew Tasker, Maryam Ardalan, Vibeke Bay, Florian Oggiano, Ming Ding, Kasper M. Hansen, Carina Mallard, Tetyana Chumak, Gregers Wegener, Alexandra Quist, Denise F. Happ
Publikováno v:
Bay, V, Happ, D F, Ardalan, M, Quist, A, Oggiano, F, Chumak, T, Hansen, K, Ding, M, Mallard, C, Tasker, R A & Wegener, G 2020, ' Flinders sensitive line rats are resistant to infarction following transient occlusion of the middle cerebral artery ', Brain Research, vol. 1737, 146797 . https://doi.org/10.1016/j.brainres.2020.146797
BACKGROUND: Depression is a common complication of stroke and increases the risk of mortality and disability. Pre-stroke depression is a possible risk factor for stroke and has also been linked to adverse outcomes. The underlying mechanisms linking d
Autor:
R. Andrew Tasker, Denise F. Happ
Publikováno v:
Happ, D F & Tasker, R A 2018, ' Effects of α7 Nicotinic Receptor Activation on Cell Survival in Rat Organotypic Hippocampal Slice Cultures ', Neurotoxicity Research, vol. 33, no. 4, pp. 887-895 . https://doi.org/10.1007/s12640-017-9854-2
Glutamatergic signaling via N-methyl-D-aspartate receptors (NMDARs) is important for physiological functioning, but can also induce cell death via excitotoxic mechanisms in many neuropathological diseases, such as stroke. Altering the cellular respon
Publikováno v:
European Neuropsychopharmacology. 28:S48-S49
Background Stroke survivors commonly experience mood disturbances, such as depression (~30%) and anxiety (~25%). Post-stroke depression (PSD) and anxiety (PSA) commonly co-occur and can negatively impact stroke outcomes [1]. For example, they are lin
Autor:
R. Andrew Tasker, Denise F. Happ
Publikováno v:
Happ, D F & Tasker, A 2016, ' A method for objectively quantifying propidium iodide exclusion in organotypic hippocampal slice cultures ', Journal of Neuroscience Methods, vol. 269, pp. 1-5 . https://doi.org/10.1016/j.jneumeth.2016.05.006
BACKGROUND: Organotypic hippocampal slice cultures (OHSCs) are an attractive in vitro model to examine mechanisms of neuronal injury, because the normal hippocampal architecture, function and cellular diversity are mostly preserved. The effects of ex