Zobrazeno 1 - 10 of 20 pro vyhledávání: '"Denise E. Lackey"'
1
TAZ Is a Negative Regulator of PPARγ Activity in Adipocytes and TAZ Deletion Improves Insulin Sensitivity and Glucose Tolerance
Autor: Gautam Bandyopadhyay, Joshua Wollam, Revathy Sampath-Kumar, Matthew Riopel, Da Young Oh, Roi Isaac, Jerrold M. Olefsky, Denise E. Lackey, Dalila El Ouarrat, Jong Bae Seo, Yun Sok Lee
Publikováno v: Cell metabolism, vol 31, iss 1
Summary Insulin resistance is a major factor in obesity-linked type 2 diabetes. PPARγ is a master regulator of adipogenesis, and small molecule agonists, termed thiazolidinediones, are potent therapeutic insulin sensitizers. Here, we studied the rol
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c672e9d63ffb002037fd9ce51c6b9833
https://escholarship.org/uc/item/0gv7h5s9
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2
Adipocyte PU.1 knockout promotes insulin sensitivity in HFD-fed obese mice
Autor: Rizaldy C. Zapata, Jachelle M. Ofrecio, Denise E. Lackey, Yun Sok Lee, Dalila El Ouarrat, Olivia Osborn, Gautam Bandyopadhyay, Felipe C.G. Reis, Roi Isaac, Da Young Oh
Publikováno v: Scientific reports, vol 9, iss 1
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)
Insulin resistance is a key feature of obesity and type 2 diabetes. PU.1 is a master transcription factor predominantly expressed in macrophages but after HFD feeding PU.1 expression is also significantly increased in adipocytes. We generated adipocy
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9120ba092959af384bf5ccef1314fce1
https://escholarship.org/uc/item/7zk4903p
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3
RalA controls glucose homeostasis by regulating glucose uptake in brown fat
Autor: Claudia Cordon, Denise E. Lackey, Chao-Wei Hung, Xiao Wei Chen, Yuliya Skorobogatko, Morgan Dragan, Peng Zhao, Martina Wallace, Dan Theodorescu, Christian M. Metallo, Olivia Osborn, Jerrold M. Olefsky, Alan R. Saltiel, Juliane G. Bogner-Strauss, Wenmin Xia, Shannon M. Reilly
Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, vol 115, iss 30
Significance The primary event in diabetes pathogenesis is the development of insulin resistance. Insulin is elevated during feeding and maintains blood glucose levels within a physiological range, largely by increasing glucose uptake in muscle and f
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc10c357f3e6d7f0030f516af33f4b55
https://europepmc.org/articles/PMC6065037/
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5
Endocrinization of FGF1 produces a neomorphic and potent insulin sensitizer
Autor: Regina Goetz, Christopher Liddle, Annette R. Atkins, Olivia Osborn, Jerrold M. Olefsky, Ronald M. Evans, Jae Myoung Suh, Ruth T. Yu, Weiwei Fan, Yun-Qiang Yin, Moosa Mohammadi, Johan W. Jonker, Maryam Ahmadian, Michael Downes, Eiji Yoshihara, Zhifeng Huang, Weilin Liu, Denise E. Lackey, Rick Havinga, Theo H. van Dijk
Publikováno v: Nature, 513(7518), 436-439. Nature Publishing Group
Fibroblast growth factor 1 (FGF1) is an autocrine/paracrine regulator whose binding to heparan sulphate proteoglycans effectively precludes its circulation. Although FGF1 is known as a mitogenic factor, FGF1 knockout mice develop insulin resistance w
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11618c3182f62ca084ad1abc9e055865
https://doi.org/10.1038/nature13540
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6
Contributions of adipose tissue architectural and tensile properties toward defining healthy and unhealthy obesity
Autor: Colin S. McCoin, Rouzbeh Mostaedi, Sean H. Adams, Denise E. Lackey, William H. Smith, Philipp E. Scherer, Mohamed R. Ali, Shundra A. Seay, Jiyoung Park, David H. Burk, Paolo Bonaldo
Publikováno v: American Journal of Physiology-Endocrinology and Metabolism. 306:E233-E246
The extracellular matrix (ECM) plays an important role in the maintenance of white adipose tissue (WAT) architecture and function, and proper ECM remodeling is critical to support WAT malleability to accomodate changes in energy storage needs. Obesit
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94880690fb0ad24a66fbf6d3a9d4c3c4
https://doi.org/10.1152/ajpendo.00476.2013
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7
Regulation of adipose branched-chain amino acid catabolism enzyme expression and cross-adipose amino acid flux in human obesity
Autor: William H. Smith, Sean H. Adams, Tracy G. Anthony, Paska Permana, Sandy M. Humphreys, Pieter J. Oort, Kristine C. Olson, Fawaz G. Haj, Ahmed Bettaieb, Tamara N. Dunn, Rouzbeh Mostaedi, Rajesh Amin, Fredrik Karpe, Dorothy A. Kieffer, Daniel Bedinger, Anthony P. Thomas, Mohamed R. Ali, Christopher J. Lynch, Denise E. Lackey
Publikováno v: American Journal of Physiology-Endocrinology and Metabolism. 304:E1175-E1187
Elevated blood branched-chain amino acids (BCAA) are often associated with insulin resistance and type 2 diabetes, which might result from a reduced cellular utilization and/or incomplete BCAA oxidation. White adipose tissue (WAT) has become apprecia
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8516945b626445c57d080ce9b56fd4ef
https://doi.org/10.1152/ajpendo.00630.2012
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8
The role of dietary fat in obesity-induced insulin resistance
Autor: Ivetta Vorobyova, Hidekazu Tsukomoto, Natalie Weber, Angelina Hernandez-Carretero, Raul Lazaro, Olivia Osborn, Andrew M.F. Johnson, Denise E. Lackey, Pingping Li
Consumption of excess calories results in obesity and insulin resistance and has been intensively studied in mice and humans. The objective of this study was to determine the specific contribution of dietary fat rather than total caloric intake to th
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59365bc57ec8416fac8798df7203bbe0
https://europepmc.org/articles/PMC5183884/
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9
Vitamin A Upregulates Matrix Metalloproteinase-9 Activity by Murine Myeloid Dendritic Cells through a Nonclassical Transcriptional Mechanism
Autor: Denise E. Lackey, Kathleen A. Hoag
Publikováno v: The Journal of Nutrition. 140:1502-1508
Myeloid dendritic cells (DC) are specialized antigen-presenting immune cells. Upon activation in peripheral tissues, DC migrate to lymph nodes to activate T lymphocytes. Matrix metalloproteinase (MMP)-9 is a gelatinase essential for DC migration. We
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89be49779ae1746503b0fc517e53ac13
https://doi.org/10.3945/jn.110.122556
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10
Vitamin A as a Regulator of Antigen Presenting Cells
Autor: Denise E. Lackey, Kathleen A. Hoag, David M. Duriancik
Publikováno v: The Journal of Nutrition. 140:1395-1399
Vitamin A has been long associated with immune system competence. Vitamin A deficiency is known to compromise many aspects of both innate and adaptive immune responses. Recent advances in retinol uptake and metabolism have identified the antigen pres
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e07f6ede54212ef11a15ab1bf54ebd67
https://doi.org/10.3945/jn.110.124461
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