Zobrazeno 1 - 10
of 183
pro vyhledávání: '"Denise E. Kirschner"'
Publikováno v:
Frontiers in Systems Biology, Vol 3 (2024)
Computational models of disease progression have been constructed for a myriad of pathologies. Typically, the conceptual implementation for pathology-related in silico intervention studies has been ad hoc and similar in design to experimental studies
Externí odkaz:
https://doaj.org/article/86874475a14645c9a49b4ee563927aac
Autor:
Pariksheet Nanda, Denise E. Kirschner
Publikováno v:
Frontiers in Applied Mathematics and Statistics, Vol 9 (2023)
Mathematical and computational models of biological systems are increasingly complex, typically comprised of hybrid multi-scale methods such as ordinary differential equations, partial differential equations, agent-based and rule-based models, etc. T
Externí odkaz:
https://doaj.org/article/cf6d58c632d14872a45ce4c905fe6438
Autor:
Soorya Janakiraman, Sophie Engels, Pariksheet Nanda, Maral Budak, Talia Greenstein, Mariana Pereira Moraes, Bree B. Aldridge, Denise E. Kirschner
Publikováno v:
STAR Protocols, Vol 4, Iss 3, Pp 102442- (2023)
Summary: Biosafety level 3 decontamination precautions motivate measuring microbial colonies using consumable photography instead of expensive automated plate counters or smartphones, and assaying drug treatments–with multiple concentrations per tr
Externí odkaz:
https://doaj.org/article/a6091adfdbaf4a2785b744c1a57ce5f3
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Some persistent infections provide a level of immunity that protects against reinfection with the same pathogen, a process referred to as concomitant immunity. To explore the phenomenon of concomitant immunity during Mycobacterium tuberculos
Externí odkaz:
https://doaj.org/article/2142c077147c49f5b7fe08c4bb5950db
Autor:
Marissa E. Renardy, Craig Gillen, Zhenhua Yang, Leonard Mukasa, Joseph Bates, Russ Butler, Denise E. Kirschner
Publikováno v:
PLOS Global Public Health, Vol 3, Iss 2 (2023)
Tuberculosis (TB) elimination in the United States remains elusive, and community-specific, localized intervention strategies may be necessary to meet elimination goals. A better understanding of the genotypic diversity of Mtb, the population subgrou
Externí odkaz:
https://doaj.org/article/fdd629e98eb7423b89bcd5950f57ecce
Autor:
Nicole L. Grant, Pauline Maiello, Edwin Klein, Philana Ling Lin, H. Jacob Borish, Jaime Tomko, L. James Frye, Alexander G. White, Denise E. Kirschner, Joshua T. Mattila, JoAnne L. Flynn
Publikováno v:
Cell Reports, Vol 39, Iss 7, Pp 110826- (2022)
Summary: Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), is a global health concern, yearly resulting in 10 million new cases of active TB. Immunologic investigation of lung granulomas is essential for understanding host c
Externí odkaz:
https://doaj.org/article/27d79ee8867c4472a720d0e7466b5302
Autor:
Jess A. Millar, J. Russell Butler, Stephanie Evans, Nicole L. Grant, Joshua T. Mattila, Jennifer J. Linderman, JoAnne L. Flynn, Denise E. Kirschner
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Externí odkaz:
https://doaj.org/article/bf3567b2577c4e5a9d254f761658596f
Autor:
Caitlin Hult, Joshua T. Mattila, Hannah P. Gideon, Jennifer J. Linderman, Denise E. Kirschner
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Neutrophil infiltration into tuberculous granulomas is often associated with higher bacteria loads and severe disease but the basis for this relationship is not well understood. To better elucidate the connection between neutrophils and pathology in
Externí odkaz:
https://doaj.org/article/ffd382aa6ff94234b3091ff7cd878378
Autor:
Jess A. Millar, J. Russell Butler, Stephanie Evans, Nicole L. Grant, Joshua T. Mattila, Jennifer J. Linderman, JoAnne L. Flynn, Denise E. Kirschner
Publikováno v:
Frontiers in Immunology, Vol 11 (2021)
Tuberculosis (TB) is a worldwide health problem; successful interventions such as vaccines and treatment require a 2better understanding of the immune response to infection with Mycobacterium tuberculosis (Mtb). In many infectious diseases, pathogen-
Externí odkaz:
https://doaj.org/article/18bc1f958e4442d3b25681c8a9dfda80
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
Tuberculosis (TB) remains as one of the world's deadliest infectious diseases despite the use of standardized antibiotic therapies. Recommended therapy for drug-susceptible TB is up to 6 months of antibiotics. Factors that contribute to lengthy regim
Externí odkaz:
https://doaj.org/article/acbad03bd7b94fb2af3327865b37c85f