Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Denise E. Fedele"'
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract Adenosine kinase (ADK), the major adenosine-metabolizing enzyme, plays a key role in brain development and disease. In humans, mutations in the Adk gene have been linked to developmental delay, stunted growth, and intellectual disability. To
Externí odkaz:
https://doaj.org/article/0bd6d0dbb5974d448b5c43cff7b1ac1a
Publikováno v:
Experimental Neurology. 200:184-190
Adenosine is an endogenous neuromodulator with anticonvulsant and neuroprotective properties presumably mediated by activation of adenosine A1 receptors (A1Rs). To study the involvement of A1Rs in neuroprotection during epileptogenesis, we induced st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::799ce9c19fac1b50bed91befb92c7082
https://doi.org/10.1016/j.expneurol.2006.02.133
https://doi.org/10.1016/j.expneurol.2006.02.133
Autor:
Laetitia Gabernet, Martin Güttinger, Nicolette Gouder, Louis Scheurer, Florence Crestani, Thomas Rülicke, Denise E. Fedele, Detlev Boison
Publikováno v:
Brain. 128:2383-2395
Adenosine kinase (ADK) is considered to be the key regulator of the brain's endogenous anticonvulsant, adenosine. In adult brain, ADK is primarily expressed in a subpopulation of astrocytes and striking upregulation of ADK in these cells has been ass
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::433f57d67b63dde1fbd59eeb53a4d215
https://doi.org/10.1093/brain/awh555
https://doi.org/10.1093/brain/awh555
Autor:
Francesca M. Coppelli, Anne M. Andrews, Amy M. Avila, Tiffany A. Mathews, Dennis L. Murphy, Denise E. Fedele
Publikováno v:
Journal of Neuroscience Methods. 140:169-181
Serotonin (5-HT) plays an integral regulatory role in mood, anxiety, cognition, appetite and aggressive behavior. Many therapeutic and illicit drugs that modulate these functions act at the serotonin transporter (SERT), thus a mouse model with reduce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0a013e58766b2ffdad45d3604186412
https://doi.org/10.1016/j.jneumeth.2004.05.017
https://doi.org/10.1016/j.jneumeth.2004.05.017
Autor:
Hanns Möhler, Elizabeth M. Simpson, Oliver Brüstle, Denise E. Fedele, Louis Scheurer, Detlev Boison, Peter Koch
Publikováno v:
Neuroscience Letters. 370:160-165
Based on the anticonvulsant and neuroprotective properties of adenosine, and based on the long-term survival potential of stem cell derived brain implants, adenosine releasing stem cells may constitute a novel tool for the treatment of epilepsy. Plur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5019aa433ea9daa8740ff02d6cd15f00
https://doi.org/10.1016/j.neulet.2004.08.031
https://doi.org/10.1016/j.neulet.2004.08.031
Autor:
Lorenz Meinel, Denise E. Fedele, Lorenz Uebersax, Claudia Schumacher, Hans P. Merkle, Detlev Boison, David L. Kaplan
Publikováno v:
Biomaterials. 27(26)
Adenosine kinase deficient (Adk−/−) embryonic stem cells (ESCs) encapsulated in synthetic polymers have previously been shown to provide therapeutic adenosine release and transient seizure suppression in epileptic rats. Here we explored the utili
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12bc1fc5d952f63f8453dd825d5d5d15
https://pubmed.ncbi.nlm.nih.gov/16709437
https://pubmed.ncbi.nlm.nih.gov/16709437
Suppression of kindled seizures by paracrine adenosine release from stem cell-derived brain implants
Autor:
Peter Koch, Oliver Brüstle, Denise E. Fedele, Martin Güttinger, William F. Pralong, Detlev Boison, Vivianne Padrun
Publikováno v:
Epilepsia. 46(8)
Summary: Purpose: Stem cells and their derivatives have emerged as a promising tool for cell-based drug delivery because of (a) their unique ability to differentiate into various somatic cell types, (b) the virtually unlimited donor source for transp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a01bf4690c2c5dccea77b4f398f61a4f
https://pubmed.ncbi.nlm.nih.gov/16060924
https://pubmed.ncbi.nlm.nih.gov/16060924
Autor:
Denise E. Fedele, Nicolette Gouder
Publikováno v:
Brain: A Journal of Neurology; Oct2005, Vol. 128 Issue 10, p2383-2395, 13p