Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Denise D. Beusen"'
Autor:
Garland R. Marshall, Denise D. Beusen
Publikováno v:
Burger's Medicinal Chemistry and Drug Discovery. :77-168
This chapter examines the approaches to molecular modeling and drug design and emphasizes their limitations. Useful information to guide the design and synthesis of potential novel therapeutics can be developed from an analysis of structure-activity
Publikováno v:
Journal of Medicinal Chemistry. 41:3609-3623
Constrained systematic search was used in an exhaustive conformational analysis of a structurally diverse set of substance P (SP) antagonists to identify a unique hypothesis for their bound conformation at the neurokinin-1 receptor. In this conformat
Autor:
Richard A. Dammkoehler, E.F. Berkley Shands, S. F. Karasek, Denise D. Beusen, Garland R. Marshall
Publikováno v:
Journal of Molecular Structure: THEOCHEM. 370:157-171
The coupling of conformation to activity and reactivity is a widely accepted concept, and as such has driven the development of tools which execute conformational searches in rapid and robust fashion [T.F. Havel, Prog. Biophys. Molec. Biol., 56 (1991
Autor:
and Kevin D. Moeller, Denise D. Beusen, Garland R. Marshall, David K. Chalmers, Urszula Slomczynska, Fabrice Cornille, Mark L. Smythe
Publikováno v:
The Journal of Organic Chemistry. 61:1198-1204
Novel, highly constrained, 6,5-bicyclic dipeptides (1-aza-5-oxa-2-oxobicyclo[4.3.0]nonane ring skeletons, 2) have been synthesized by a one-step electrochemical cyclization from the dipeptides Boc-(S)-serine-(S)-proline-OMe (Boc-(S)-Ser-(S)-Pro-OMe,
Autor:
Jeff L.-F. Kao, Garland R. Marshall, Urszula Slomczynska, Janusz Zabrocki, Richard D. Head, Denise D. Beusen
Publikováno v:
Biopolymers. 36:181-200
Potent, cyclic hexapeptide analogues of somatostatin are generally believed to adopt some common secondary structural features: a II′ β turn at one end of the cycle, and a type VI turn with a cis amide bond at the other. A proposed cis amide surro
Autor:
Fabrice Cornille, Kevin D. Moeller, Urszula Slomczynska, Garland R. Marshall, Denise D. Beusen, Mark L. Smythe
Publikováno v:
Journal of the American Chemical Society. 117:909-917
Autor:
Yvette M. Fobian, Fabrice Cornille, Kevin D. Moeller, Denise D. Beusen, Garland R. Marshall, Urszula Slomczynska
Publikováno v:
Tetrahedron Letters. 35:6989-6992
A pair of bicyclic lactam based conformationally restricted peptide mimetics have been synthesized in good yield by the direct anodic oxidation of dipeptides. This work highlights the simplicity of using electrochemistry to construct peptide mimetics
Autor:
William C. Hutton, Karol Kociolek, Miroslaw T. Leplawy, Fritz Reusser, Janusz Zabrocki, Denise D. Beusen, Urszula Slomczynska, Adam S. Redlinski, Garland R. Marshall
Publikováno v:
ChemInform. 23
The peptaibol antibiotics, emerimicin III and IV (Ac-Phe 1 -MeA 2 -MeA 3 -MeA 4 -Val 5 -Gly 6 -Leu 7 -MeA 8 -MeA 9 - Hyp 10 -Gln 11 -R-EtA 12 -Hyp 13 -Xxx 14 -Phol 15 , where Xxx=Ala for emerimicin III and Xxx=MeA for emerimicin IV) and their EtA 12
Autor:
Urszula Slomczynska, Garland R. Marshall, Kevin D. Moeller, Yvette M. Fobian, Fabrice Cornille, Denise D. Beusen
Publikováno v:
ChemInform. 26
A pair of bicyclic lactam based conformationally restricted peptide mimetics have been synthesized in good yield by the direct anodic oxidation of dipeptides. This work highlights the simplicity of using electrochemistry to construct peptide mimetics
Publikováno v:
ChemInform. 27