Challenges and insights in the exploration of the low abundance human ocular surface microbiome

Autor: Elio L. Herzog, Marco Kreuzer, Martin S. Zinkernagel, Denise C. Zysset-Burri

Publikováno v: Frontiers in Cellular and Infection Microbiology, Vol 13 (2023)

PurposeThe low microbial abundance on the ocular surface results in challenges in the characterization of its microbiome. The purpose of this study was to reveal factors introducing bias in the pipeline from sample collection to data analysis of low-

Externí odkaz: https://doaj.org/article/c4ecb4365c714c12b9b4cfd0951fbcc7

The importance of age in compositional and functional profiling of the human intestinal microbiome

Autor: Elio L. Herzog, Melania Wäfler, Irene Keller, Sebastian Wolf, Martin S. Zinkernagel, Denise C. Zysset-Burri

Publikováno v: PLoS ONE, Vol 16, Iss 10 (2021)

The intestinal microbiome plays a central role in human health and disease. While its composition is relatively stable throughout adulthood, the microbial balance starts to decrease in later life stages. Thus, in order to maintain a good quality of l

Externí odkaz: https://doaj.org/article/59a47782aa714f4faf4a5b56554f2d74

Associations of the intestinal microbiome with the complement system in neovascular age-related macular degeneration

Autor: Lieselotte Berger, Carlo R. Largiadèr, Denise C. Zysset-Burri, Matthias Wittwer, Martin S. Zinkernagel, Sebastian Wolf, Irene Keller

Publikováno v: npj Genomic Medicine, Vol 5, Iss 1, Pp 1-11 (2020)
NPJ Genomic Medicine
Zysset-Burri, Denise C.; Keller, Irene; Berger, Lieselotte E.; Largiadèr, Carlo R.; Wittwer, Matthias; Wolf, Sebastian; Zinkernagel, Martin S. (2020). Associations of the intestinal microbiome with the complement system in neovascular age-related macular degeneration. NPJ genomic medicine, 5(34), p. 34. Springer Nature 10.1038/s41525-020-00141-0

Age-related macular degeneration (AMD) is a leading cause of severe vision loss in the aged population. The etiology of AMD is multifactorial including nutritional factors, genetic variants mainly in the complement pathway, environmental risk factors

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::698a37bd10142a6077e6a01ba308fb64
http://link.springer.com/article/10.1038/s41525-020-00141-0

Genomics and transcriptomics yields a system-level view of the biology of the pathogen Naegleria fowleri

Autor: Kristína Záhonová, Lillian K. Fritz-Laylin, Georgina Macintyre, Denise C. Zysset-Burri, Michael L. Ginger, Marek Eliáš, Matthew T. Weirauch, Joel B. Dacks, Geoffrey J. Puzon, Inmaculada Ramírez-Macías, Tom Walsh, Emily K. Herman, Anastasios D. Tsaousis, Katrina B. Velle, Alexander L. Greninger, Francine Marciano-Cabral, Romana Vargová, Norbert Müller, Charles Y. Chiu, Sebastian Rodrigo Najle, Mark van der Giezen, Haylea C. Miller, Claudio H. Slamovits, Matthew J. Morgan, Mattias Wittwer

Publikováno v: BMC Biology
Herman, Emily K; Greninger, Alex; van der Giezen, Mark; Ginger, Michael L; Ramirez-Macias, Inmaculada; Miller, Haylea C; Morgan, Matthew J; Tsaousis, Anastasios D; Velle, Katrina; Vargová, Romana; Záhonová, Kristína; Najle, Sebastian Rodrigo; MacIntyre, Georgina; Muller, Norbert; Wittwer, Mattias; Zysset-Burri, Denise Corinne; Eliáš, Marek; Slamovits, Claudio H; Weirauch, Matthew T; Fritz-Laylin, Lillian; ... (2021). Genomics and transcriptomics yields a system-level view of the biology of the pathogen Naegleria fowleri. BMC biology, 19(1), p. 142. BioMed Central 10.1186/s12915-021-01078-1
BMC Biology, Vol 19, Iss 1, Pp 1-18 (2021)
Digital.CSIC. Repositorio Institucional del CSIC
instname

[Background] The opportunistic pathogen Naegleria fowleri establishes infection in the human brain, killing almost invariably within 2 weeks. The amoeba performs piece-meal ingestion, or trogocytosis, of brain material causing direct tissue damage an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f65e98aaa4032faf2ad946d969104d0b
https://doi.org/10.1186/s12915-021-01078-1

A comparative ‘omics approach to candidate pathogenicity factor discovery in the brain-eating amoebaNaegleria fowleri

Autor: Norbert Müller, Mark van der Giezen, Claudio H. Slamovits, Kristína Záhonová, Denise C. Zysset-Burri, Matthew T. Weirauch, Anastasios D. Tsaousis, Sebastian Rodrigo Najle, Haylea C. Miller, Katrina B. Velle, Matthias Wittwer, Marek Eliáš, Tom Walsh, Romana Vargová, Joel B. Dacks, Geoffrey J. Puzon, Francine Marciano-Cabral, Charles Y. Chiu, Michael L. Ginger, Alex Greninger, Lillian K. Fritz-Laylin, Georgina Macintyre, Inmaculada Ramírez-Macías, Emily K. Herman, Matthew J. Morgan

Of the 40 describedNaegleriaspecies, onlyN. fowlerican establish infection in humans, killing almost invariably within two weeks. In the brain, the amoeba performs piece-meal ingestion, or trogocytosis, of brain material causing massive inflammation.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f70e65bd960ae9dfa831ed97b6ac54d1
https://doi.org/10.1101/2020.01.16.908186