Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Denise C. Miles"'
Autor:
Nienke A. de Vries, Danielle Hulsman, Waseem Akhtar, Johann de Jong, Denise C. Miles, Marleen Blom, Olaf van Tellingen, Jos Jonkers, Maarten van Lohuizen
Publikováno v:
Cell Reports, Vol 10, Iss 3, Pp 383-397 (2015)
EZH2 is frequently overexpressed in glioblastoma (GBM), suggesting an oncogenic function that could be a target for therapeutic intervention. However, reduced EZH2 activity can also promote tumorigenesis, leading to concerns about the use of EZH2 inh
Externí odkaz:
https://doaj.org/article/54dcc483deca4827a54ac64469f6ef27
Autor:
Tom S. Weber, Christine Biben, Denise C. Miles, Stefan Glaser, Sara Tomei, Stephen Zhang, Patrick P. L. Tam, Samir Taoudi, Shalin H. Naik
Contribution of the mammalian epiblast to fetal organs during embryogenesis has been investigated using reporters of marker genes, or through single cell or spatial RNA sequencing to infer differentiation trajectories. However, much remains to be lea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1db86fc92d1177c437df38e49b42f47a
https://doi.org/10.1101/2023.01.02.522501
https://doi.org/10.1101/2023.01.02.522501
Autor:
Katie A. Fennell, Dane Vassiliadis, Enid Y. N. Lam, Luciano G. Martelotto, Jesse J. Balic, Sebastian Hollizeck, Tom S. Weber, Timothy Semple, Qing Wang, Denise C. Miles, Laura MacPherson, Yih-Chih Chan, Andrew A. Guirguis, Lev M. Kats, Emily S. Wong, Sarah-Jane Dawson, Shalin H. Naik, Mark A. Dawson
Publikováno v:
Nature. 601:125-131
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eca5ec36241dd90dcfbc07c2d0e36859
https://doi.org/10.1038/s41586-021-04206-7
https://doi.org/10.1038/s41586-021-04206-7
Autor:
Denise C Miles, Stephanie I Wakeling, Jessica M Stringer, Jocelyn A van den Bergen, Dagmar Wilhelm, Andrew H Sinclair, Patrick S Western
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e54606 (2013)
The developing testis provides an environment that nurtures germ cell development, ultimately ensuring spermatogenesis and fertility. Impacts on this environment are considered to underlie aberrant germ cell development and formation of germ cell tum
Externí odkaz:
https://doaj.org/article/e7f2b59458ea4d6b968f5ba8f98802d4
Autor:
Katie A, Fennell, Dane, Vassiliadis, Enid Y N, Lam, Luciano G, Martelotto, Jesse J, Balic, Sebastian, Hollizeck, Tom S, Weber, Timothy, Semple, Qing, Wang, Denise C, Miles, Laura, MacPherson, Yih-Chih, Chan, Andrew A, Guirguis, Lev M, Kats, Emily S, Wong, Sarah-Jane, Dawson, Shalin H, Naik, Mark A, Dawson
Publikováno v:
Nature. 601(7891)
All cancers emerge after a period of clonal selection and subsequent clonal expansion. Although the evolutionary principles imparted by genetic intratumour heterogeneity are becoming increasingly clear
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8459e6cb4928f5f8f8255b8ea866fba1
https://pubmed.ncbi.nlm.nih.gov/34987227
https://pubmed.ncbi.nlm.nih.gov/34987227
Autor:
Danielle Hulsman, Nienke A. de Vries, Waseem Akhtar, Ewa Gogola, Martijn A.J. Koppens, Cor Lieftink, Santiago Gisler, Roderick L. Beijersbergen, Inka Pawlitzky, Denise C. Miles, Maarten van Lohuizen, Ellen Tanger
Publikováno v:
Stem Cells. 35:147-157
Since the discovery of induced pluripotent stem cells there has been intense interest in understanding the mechanisms that allow a somatic cell to be reprogrammed back to a pluripotent state. Several groups have studied the alterations in gene expres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::028d0a3592c8dcaf3ee7ae72b1581a17
https://doi.org/10.1002/stem.2453
https://doi.org/10.1002/stem.2453
Autor:
Emanuele Pelosi, Patrick S. Western, Dagmar Wilhelm, Andrew H. Sinclair, Raphael H. Rastetter, Kirsten Hogg, Denise C. Miles, Sonja E. Gustin, Jessica M Stringer
Publikováno v:
Developmental Biology. 412:250-260
Sexual development is initiated through differentiation of testicular Sertoli cells or ovarian granulosa cells. Although these supporting cells are considered to develop from common bipotential precursors, recent evidence suggests that distinct suppo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4a0f44e6a27518641a0d14f80570a0b
https://doi.org/10.1016/j.ydbio.2016.02.024
https://doi.org/10.1016/j.ydbio.2016.02.024
Publikováno v:
BMC Systems Biology
Background Cellular barcoding is a recently developed biotechnology tool that enables the familial identification of progeny of individual cells in vivo. In immunology, it has been used to track the burst-sizes of multiple distinct responding T cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad428fcb4a97e9536b509ad449615010
http://eprints.maynoothuniversity.ie/8187/
http://eprints.maynoothuniversity.ie/8187/
Autor:
Patrick S. Western, Andrew H. Sinclair, Jocelyn van den Bergen, Denise C. Miles, Stephanie I. Wakeling, Richard B. Anderson
Publikováno v:
Developmental Biology. 365:101-109
The spermatogenic and oogenic lineages originate from bipotential primordial germ cells in response to signalling in the foetal testis or ovary, respectively. The signals required for male germ cell commitment and their entry into mitotic arrest rema
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7eb6b29f22d02fb244ff1ede2106131f
https://doi.org/10.1016/j.ydbio.2012.02.014
https://doi.org/10.1016/j.ydbio.2012.02.014
Publikováno v:
Cell Cycle. 9:408-418
During mouse embryonic development germ cells proliferate extensively until they commit to the male or female pathway and arrest in mitosis or meiosis respectively. Whilst the transition of female germ cells exiting the mitotic cell cycle and enterin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4067f11997dfd9fd9564b83ea4a5f6db
https://doi.org/10.4161/cc.9.2.10691
https://doi.org/10.4161/cc.9.2.10691