Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Denise C. Matzelle"'
Autor:
Swapan K. Ray, Abhay K. Varma, Arabinda Das, Supriti Samantaray, Naren L. Banik, Denise C. Matzelle, Shan Ping Yu, Ling Wei
Publikováno v:
Journal of neurochemistry. 137(4)
Spinal cord injury (SCI) causes loss of neurological function and, depending upon the severity of injury, may lead to paralysis. Currently, no FDA-approved pharmacotherapy is available for SCI. High-dose methylprednisolone is widely used, but this tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f658ee1f65b283ed70bf60ba298a66a7
https://pubmed.ncbi.nlm.nih.gov/26998684
https://pubmed.ncbi.nlm.nih.gov/26998684
Autor:
Supriti Samantaray, Abhay K. Varma, Naren L. Banik, Swapan K. Ray, Denise C. Matzelle, Shan Ping Yu, Ling Wei, Arabinda Das
Publikováno v:
Journal of neurochemistry. 136(5)
Spinal cord injury (SCI) is a debilitating condition with neurological deficits and loss of motor function that, depending on the severity, may lead to paralysis. The only treatment currently available is methylprednisolone, which is widely used and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c2cb7b7328a9f84bc533ceb05c4843e
https://pubmed.ncbi.nlm.nih.gov/26662641
https://pubmed.ncbi.nlm.nih.gov/26662641
Publikováno v:
Brain Research. 867:80-89
Calpain, a Ca 2+ -dependent cysteine protease, has been implicated in cytoskeletal protein degradation and neurodegeneration in the lesion and adjacent areas following spinal cord injury (SCI). To attenuate apoptosis or programmed cell death (PCD) in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69998ea0e95be3cc5927bdb2f99832ec
https://doi.org/10.1016/s0006-8993(00)02260-5
https://doi.org/10.1016/s0006-8993(00)02260-5
Autor:
Swapan K. Ray, Donald C. Shields, Gloria G. Wilford, Edward L. Hogan, Takaomi C. Saido, Naren L. Banik, Denise C. Matzelle
Publikováno v:
Brain Research. 816:375-380
Calpain, a calcium-activated neutral proteinase, has been implicated in myelin and cytoskeletal protein degradation following spinal cord injury. In the present study, we examined the activity and transcriptional expression of calpain in spinal cord
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c191ecd7efab0e554b1b1250768e193f
https://doi.org/10.1016/s0006-8993(98)01128-7
https://doi.org/10.1016/s0006-8993(98)01128-7
Autor:
Edward L. Hogan, Denise C. Matzelle, Gloria G. Wilford, Naren L. Banik, Swapan K. Ray, Lawrence F. Eng
Publikováno v:
Role of Proteases in the Pathophysiology of Neurodegenerative Diseases ISBN: 9780306465796
Injury to the central nervous system (CNS) [e.g., spinal cord injury (SCI) and traumatic brain injury (TBI)] is one of the main health problems in the United States as well as in the world. CNS injury is also a major killer in the United States. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::29b1f62488d1208ab1662ce11cd443a0
https://doi.org/10.1007/0-306-46847-6_14
https://doi.org/10.1007/0-306-46847-6_14
Publikováno v:
Annals of the New York Academy of Sciences. 890
Intracellular free Ca2+ and free radicals are increased following spinal cord injury (SCI). These can activate calpain to degrade cytoskeletal proteins leading to apoptotic and necrotic cell death. Primary injury triggers a cascade of secondary injur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51b16f38da79e34170b53791f18717f1
https://pubmed.ncbi.nlm.nih.gov/10668431
https://pubmed.ncbi.nlm.nih.gov/10668431
Increased calpain content and progressive degradation of neurofilament protein in spinal cord injury
Publikováno v:
Brain research. 752(1-2)
Spinal cord injury was induced in rat by weight drop. The extent of degradation of neurofilament proteins in the lesion following trauma was examined and served as a measure of calpain activity. Calpain was identified in the samples by myelin mealpai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73b447bc954dc297edb3a7b0950cfe8e
https://pubmed.ncbi.nlm.nih.gov/9106471
https://pubmed.ncbi.nlm.nih.gov/9106471