Výsledky vyhledávání - "Denise C. LaTemple"

Adult and neonatal anti-Gal response in knock-out mice for ?1,3galactosyltransferase

Publikováno v: Xenotransplantation. 5:191-196

The knockout mouse to alpha1,3galactosyltransferase (alpha1,3GT KO) lacks the ability to synthesize alpha-gal epitopes (Galalpha1,3Galbeta1,4GlcNAc-R) and is capable of producing low amounts of the natural anti-Gal antibody. The present study indicat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::033cd24ae7b0a4956d37fdad60f443c9
https://doi.org/10.1111/j.1399-3089.1998.tb00027.x

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A SENSITIVE ASSAY FOR MEASURING ??-GAL EPITOPE EXPRESSION ON CELLS BY A MONOCLONAL ANTI-GAL ANTIBODY1

Autor: Marko Z. Radic, Uri Galili, Denise C. LaTemple

Publikováno v: Transplantation. 65:1129-1132

Background The assessment of a-gal epitope (Galalpha1-3Galbeta1-4GlcNAc-R) expression on various cells and tissues is important for the prediction of anti-Gal-mediated immune rejection of xenografts. This study describes an enzyme-linked immunosorben

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3be7f5b87ef54d4ca7c5c9fbefa86790
https://doi.org/10.1097/00007890-199804270-00020

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Natural anti-Gal antibody as a universal augmenter of autologous tumor vaccine immunogenicity

Autor: Denise C. LaTemple, Uri Galili

Publikováno v: Immunology Today. 18:281-285

The immunogenicity of tumor-associated antigens (TAAs) in autologous tumor vaccines is usually very low. Here, the possibility is discussed that TAA immunogenicity might be increased in any human tumor-cell vaccine by engineering the vaccinating memb

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7f7a064e69069b5074e0fe9898796d7
https://doi.org/10.1016/s0167-5699(97)80024-2

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Enhancement of Autologous Tumor Vaccine Immunogenicity by Anti-Gal

Autor: Uri Galili, Denise C. LaTemple

Publikováno v: α-Gal and Anti-Gal ISBN: 9781461371601

Anti-Gal is considered to be the most prevalent naturally occurring antibody common to all humans. It represents approximately 1 % of total IgG in the serum in humans and interacts specifically with the α-gal epitope of cell surface glycoproteins an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9cbc4ec93ca22bcc9a6be5cb8fc25b64
https://doi.org/10.1007/978-1-4615-4771-6_15

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The Natural Anti-Gal Antibody

Autor: Uri Galili, Marko Z. Radic, Le Wang, Denise C. LaTemple

Publikováno v: α-Gal and Anti-Gal ISBN: 9781461371601

Anti-Gal is the most abundant antibody found in humans. It constitutes 1 % of circulating antibodies and interacts specifically with the α-gal epitope (Galα1-3Galβl-4GlcNAc-R). This chapter describes the studies which have red to the identificatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::03cd138c14a225d019e68df3659d7e1c
https://doi.org/10.1007/978-1-4615-4771-6_4

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Tumor Cell Responses to IFNγ Affect Tumorigenicity and Response to IL-12 Therapy and Antiangiogenesis

Autor: William M. F. Lee, Michael S. Gee, Denise C. LaTemple, Joshua M. Farber, Xiaojing Ma, Sidney Pestka, Maria Wysocka, Kevin E. Salhany, Fang Liao, Christina M. Coughlin, Giorgia Gri, Serguei V. Kotenko, Li Liu, Giorgio Trinchieri, Ji Eun Kim

Publikováno v: Immunity. (1):25-34

Expression of a dominant negative mutant IFNgammaR1 in murine SCK and K1735 tumor cells rendered them relatively unresponsive to IFNgamma in vitro and more tumorigenic and less responsive to IL-12 therapy in vivo. IL-12 induced histologic evidence of

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