PLP2-derived peptide Rb4 triggers PARP-1-mediated necrotic death in murine melanoma cells

Autor: Vera S. C. Maia, Rodrigo Berzaghi, Denise C. Arruda, Fabrício C. Machado, Leticia L. Loureiro, Pollyana M. S. Melo, Alice S. Morais, Alexandre Budu, Luiz R. Travassos

Publikováno v: Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)

Abstract Malignant melanoma is the main cause of death in patients with skin cancer. Overexpression of Proteolipid protein 2 (PLP2) increased tumor metastasis and the knockdown of PLP2 inhibited the growth and metastasis of melanoma cells. In the pre

Externí odkaz: https://doaj.org/article/2eba05a1f58f4d17ba9257b2a26b3996

Co-Encapsulation of Methylene Blue and PARP-Inhibitor into Poly(Lactic-Co-Glycolic Acid) Nanoparticles for Enhanced PDT of Cancer

Autor: Jéssica A. Magalhães, Denise C. Arruda, Maurício S. Baptista, Dayane B. Tada

Publikováno v: Nanomaterials, Vol 11, Iss 6, p 1514 (2021)

The development of resistance against photodamage triggered by photodynamic therapy (PDT) is ascribed mainly to the cellular redox defenses and repair. If the tumor tissue is not promptly eliminated by the first few PDT sessions, PDT-resistance can b

Externí odkaz: https://doaj.org/article/2c2cc8b5bc88465b9993ddc9f58cdcef

FTY720 induces apoptosis in B16F10-NEX2 murine melanoma cells, limits metastatic development in vivo, and modulates the immune system

Autor: Felipe V. Pereira, Denise C. Arruda, Carlos R. Figueiredo, Mariana H. Massaoka, Alisson L. Matsuo, Valquiria Bueno, Elaine G. Rodrigues

Publikováno v: Clinics, Vol 68, Iss 7, Pp 1018-1027 (2013)

OBJECTIVE: Available chemotherapy presents poor control over the development of metastatic melanoma. FTY720 is a compound already approved by the Food and Drug Administration for the treatment of patients with multiple sclerosis. It has also been obs

Externí odkaz: https://doaj.org/article/bf968af2f16d444fa768f019b9c144d1

Intracellular Targeting of Poly Lactic-Co-Glycolic Acid Nanoparticles by Surface Functionalization with Peptides

Autor: Thaís Dolzany de Oliveira, Denise C. Arruda, Luiz R. Travassos, Dayane Batista Tada

Publikováno v: Journal of biomedical nanotechnology. 17(7)

Nanoparticles (NPs) are a promising strategy for delivering drugs to specific sites because of their tunable size and surface chemistry variety. Among the availablematerials, NPs prepared with biopolymers are of particular interest because of their b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::068942be01f9ab728b837e8ce7cb571d
https://pubmed.ncbi.nlm.nih.gov/34446135

In Vitro and In Vivo Inhibitory Activity of Limonene against Different Isolates of Candida spp

Autor: Diego C. P. Rossi, Denise C. Arruda, David Aciole Barbosa, Julián E. Muñoz, Fernanda F. M. Cunha, Carlos Pelleschi Taborda, Daniela L. Jabes, Luiz R. Nunes

Publikováno v: Journal of Fungi
Volume 6
Issue 3
Journal of Fungi, Vol 6, Iss 183, p 183 (2020)
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Commensal yeast from the genus Candida is part of the healthy human microbiota. In some cases, Candida spp. dysbiosis can result in candidiasis, the symptoms of which may vary from mild localized rashes to severe disseminated infections. The most pre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8c6696386325d81c26261ce2c0878a7
http://europepmc.org/articles/PMC7559214