Exosomal Composition, Biogenesis and Profiling Using Point-of-Care Diagnostics—Implications for Cardiovascular Disease

Autor: Denise Burtenshaw, Brian Regan, Kathryn Owen, David Collins, David McEneaney, Ian L. Megson, Eileen M. Redmond, Paul Aidan Cahill

Publikováno v: Frontiers in Cell and Developmental Biology, Vol 10 (2022)

Arteriosclerosis is an important age-dependent disease that encompasses atherosclerosis, in-stent restenosis (ISR), pulmonary hypertension, autologous bypass grafting and transplant arteriosclerosis. Endothelial dysfunction and the proliferation of v

Externí odkaz: https://doaj.org/article/576c5cfbd4c64084b2e96667d7d0adf4

Reactive Oxygen Species (ROS), Intimal Thickening, and Subclinical Atherosclerotic Disease

Autor: Denise Burtenshaw, Michael Kitching, Eileen M. Redmond, Ian L. Megson, Paul A. Cahill

Publikováno v: Frontiers in Cardiovascular Medicine, Vol 6 (2019)

Arteriosclerosis causes significant morbidity and mortality worldwide. Central to this process is the development of subclinical non-atherosclerotic intimal lesions before the appearance of pathologic intimal thickening and advanced atherosclerotic p

Externí odkaz: https://doaj.org/article/4ab051d91f304c05a15f8c69d0aac728

Disease-Relevant Single Cell Photonic Signatures Identify S100β Stem Cells and their Myogenic Progeny in Vascular Lesions

Autor: Lourdes Albina Nirupa Julius, Killian Healy, Roya Hakimjavadi, Eileen M. Redmond, Andreu Llobera, Yusof Gusti, Weimin Liu, Michael Kitching, Emma Fitzpatrick, Emma K. Finlay, Damien King, Mariana Di Luca, David Kernan, Abidemi Olayinka, Paul A. Cahill, Claire Molony, Denise Burtenshaw, Jens Ducrée, David A. Morrow

Publikováno v: Stem cell reviews and reports
Molony, Claire, King, Damien, Di Luca, Mariana, Kitching, Michael ORCID: 0000-0002-9884-0790 , Olayinka, Abidemi, Hakimjavadi, Roya, Julius, Lourdes A.N., Fitzpatrick, Emma, Gusti, Yusof, Burtenshaw, Denise ORCID: 0000-0002-5958-1773 , Healy, Killian, Finlay, Emma K. ORCID: 0000-0003-0621-2744 , Kernan, David, Llobera, Andreu ORCID: 0000-0002-2941-478X , Liu, Weimin, Morrow, David, Redmond, Eileen M. ORCID: 0000-0001-8642-4418 , Ducrée, Jens ORCID: 0000-0002-0366-1897 and Paul, Cahill ORCID: 0000-0002-5385-6502 (2021) Disease-relevant single cell photonic signatures identify S100β stem cells and their myogenic progeny in vascular lesions. Stem Cell Reviews and Reports, 17 . pp. 1713-1740. ISSN 2629-3269
Molony, Claire, King, Damien ORCID: 0000-0001-7720-064X , Di Luca, Mariana, Kitching, Michael ORCID: 0000-0002-9884-0790 , Olayinka, Abidemi, Hakimjavadi, Roya, Julius, Lourdes A.N., Fitzpatrick, Emma, Gusti, Yusof, Burtenshaw, Denise, Healy, Killian, Finlay, Emma K. ORCID: 0000-0003-0621-2744 , Kernan, David, Llobera, Andreu ORCID: 0000-0002-2941-478X , Liu, Weimin, Morrow, David, Redmond, Eileen M. ORCID: 0000-0001-8642-4418 , Ducrée, Jens and Cahill, Paul A. ORCID: 0000-0002-5385-6502 (2021) Disease-relevant single cell photonic signatures identify S100β stem cells and their myogenic progeny in vascular lesions. Stem Cell Reviews and Reports, 17 . pp. 1713-1740. ISSN 2629-3269

A hallmark of subclinical atherosclerosis is the accumulation of vascular smooth muscle cell (SMC)-like cells leading to intimal thickening and lesion formation. While medial SMCs contribute to vascular lesions, the involvement of resident vascular s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cfeddfb7778f1f404a4ad148e72048f
https://doi.org/10.1007/s12015-021-10125-x

The calcium binding protein S100β marks hedgehog-responsive resident vascular stem cells within vascular lesions

Autor: Eileen M. Redmond, Weimin Liu, Emma Fitzpatrick, Jay-Christian Helt, Roya Hakimjavadi, Daniel Sheridan, Denise Burtenshaw, Eoin Corcoran, Susan Harman, Yusof Gusti, Catriona Lally, Paul A. Cahill, Mariana Di Luca

Publikováno v: NPJ Regenerative Medicine
npj Regenerative Medicine, Vol 6, Iss 1, Pp 1-15 (2021)
Di Luca, Mariana, Fitzpatrick, Emma, Burtenshaw, Denise, Liu, Weimin, Helt, Jay-Christian, Hakimjavadi, Roya, Corcoran, Eoin, Gusti, Yusof, Sheridan, Daniel ORCID: 0000-0003-3322-2606 , Harman, Susan, Lally, Catriona, Redmond, Eileen M. ORCID: 0000-0001-8642-4418 and Cahill, Paul A. ORCID: 0000-0002-5385-6502 (2021) The calcium binding protein S100β marks hedgehog-responsive resident vascular stem cells within vascular lesions. npj Regenerative medicine, 6 . ISSN 2057-3995

A hallmark of subclinical atherosclerosis is the accumulation of vascular smooth muscle cell (SMC)-like cells leading to intimal thickening. While medial SMCs contribute, the participation of hedgehog responsive resident vascular stem cells (vSCs) to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3591696c2e434a72524579ececa1a495
http://europepmc.org/articles/PMC7921434

The Calcium Binding Protein S100β Marks Hedgehog-Responsive Perivascular Stem Cells That Contribute to Intimal Thickening Following Iatrogenic Flow Restriction

Autor: Susan Harman, Emma Fitzpatrick, Eileen M. Redmond, Roya Hakimjavadi, Weimin Liu, Jay-Christian Helt, Yusof Gusti, Paul A. Cahill, Eoin Corcoran, Mariana Di Luca, Caitríona Lally, Daniel Sheridan, Denise Burtenshaw

Publikováno v: SSRN Electronic Journal.

The origin(s) of smooth muscle-like cells contributing to the development of subclinical arteriosclerosis remains controversial. Using Sca1-eGFP and S100β-eGFP transgenic mice together with genetic lineage tracing of S100β+ vascular stem cells (vSC

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::36f22f2f8a342eda818de4c2461f03ee
https://doi.org/10.2139/ssrn.3599853