Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Denise Blum-Kaelin"'
Autor:
Eric J. Niesor, Christine Magg, Naoto Ogawa, Hiroshi Okamoto, Elisabeth von der Mark, Hugues Matile, Georg Schmid, Roger G. Clerc, Evelyne Chaput, Denise Blum-Kaelin, Walter Huber, Ralf Thoma, Philippe Pflieger, Makoto Kakutani, Daisuke Takahashi, Gregor Dernick, Cyrille Maugeais
Publikováno v:
Journal of Lipid Research, Vol 51, Iss 12, Pp 3443-3454 (2010)
The mechanism by which cholesteryl ester transfer protein (CETP) activity affects HDL metabolism was investigated using agents that selectively target CETP (dalcetrapib, torcetrapib, anacetrapib). In contrast with torcetrapib and anacetrapib, dalcetr
Externí odkaz:
https://doaj.org/article/6b0ce888f3634531a2b4ff3ba44e3457
Autor:
Henrietta Dehmlow, Ralf Thoma, Armin Ruf, Narendra Panday, Elisabeth Von Der Mark, Olivier Morand, Hans Peter Märki, Manfred Kansy, Peter Hartman, Philippe Coassolo, Alexander Chucholowski, Denise Blum-Kaelin, Johannes Aebi, Jean Ackermann, Tanja Schulz-Gasch
Publikováno v:
CHIMIA, Vol 59, Iss 3 (2005)
Novel inhibitors of oxidosqualene cyclase (OSC) for the treatment of dyslipidemia are reported. Starting point for the chemistry program was a set of compounds derived from a fungicide project which, in addition to high affinity for OSC from Candida
Externí odkaz:
https://doaj.org/article/52a208c1b0c345b49b3846af115d21f8
Autor:
Peter Hartman, Denise Blum-Kaelin, Warot Xavier Marie, Vanessa Bourgeaux, Bernd Kuhn, Henrietta Dehmlow, Narendra Panday, Hassen Ratni, Jörg Benz, Matthew Blake Wright
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:5231-5237
A series of branched and unbranched anilinohexafluoroisopropanols related to the known sulfonamide T0901317 were prepared and evaluated as activators/modulators of both LXRalpha and LXRbeta. A structure-activity relationship was established and compo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94b2410b76a5acb85ee64d14fe5948e7
https://doi.org/10.1016/j.bmcl.2006.06.081
https://doi.org/10.1016/j.bmcl.2006.06.081
Autor:
Christian Oefner, Johannes Aebi, Glenn E. Dale, Stefan Sahli, François Diederich, Hans-Joachim Böhm, W. Bernd Schweizer, Brian Frank, Denise Blum-Kaelin
Publikováno v:
Helvetica Chimica Acta. 88:731-750
A new class of nonpeptidic inhibitors of the ZnII-dependent metalloprotease neprilysin with IC50 values in the nanomolar activity range (0.034–0.30 μM) were developed based on structure-based de novo design (Figs. 1 and 2). The inhibitors feature
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6dcef800a1157dff7200eafccb7809a0
https://doi.org/10.1002/hlca.200590051
https://doi.org/10.1002/hlca.200590051
Autor:
Hans-Joachim Böhm, Johannes Aebi, Tobias Welti, Bernhard Stump, Denise Blum-Kaelin, W. Bernd Schweizer, François Diederich, Stefan Sahli
Publikováno v:
Helvetica Chimica Acta. 88:707-730
Neprilysin (NEP; neutral endopeptidase EC 3.4.24.11) is a Zn-II-dependent, membrane-bound endopeptidase. NEP is widely distributed in the organs, particularly in the kidneys and lungs, and it is involved in the metabolism of a number of smaller regul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::31eb9ca7dde05813a171953dfc27a695
https://doi.org/10.1002/hlca.200590050
https://doi.org/10.1002/hlca.200590050
Autor:
Bernd-Michael Löffler, Johannes Aebi, Lucienne Juillerat-Jeanneret, Eric A. Kitas, Henrietta Dehmlow, Denise Blum-Kaelin, Yann Berger
Publikováno v:
Journal of Medicinal Chemistry. 48:483-498
Endothelin-1 (ET-1) is mitogenic and/or antiapoptotic in human cancers, and antagonists to ET-1 receptors are under evaluation for cancer treatment. Inhibition of ET-1 activation by the endothelin-converting enzymes 1(a)(-)(d) (ECE-1(a)(-)(d); EC 3.4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c7bf69be97812c9ac781edfb3e969e4
https://doi.org/10.1021/jm040857x
https://doi.org/10.1021/jm040857x
Autor:
Denise Blum-Kaelin, Tobias Welti, François Diederich, Bernhard Stump, Hans-Joachim Böhm, Johannes Aebi, Stefan Sahli, Christian Oefner
Publikováno v:
ChemBioChem. 5:996-1000
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e18f293ac19997ea847a890713d40476
https://doi.org/10.1002/cbic.200400005
https://doi.org/10.1002/cbic.200400005
Autor:
Matthew Blake Wright, Raffaello Masciadri, Denise Blum-Kaelin, Cyrille Maugeais, Henrietta Dehmlow, Hassen Ratni, Narendra Panday, Angelique Patiny-Adam, Peter Hartman, Philippe Jablonski
Publikováno v:
Bioorganicmedicinal chemistry letters. 19(6)
A series of tetrahydro-cyclopenta[b]indoles modulating the activity of the liver-X-receptor (LXR) were derived from a high throughput screening hit. The potency and selectivity for LXRβ versus LXRα was improved. One compound, administered to wild-t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7666abbeb40d20e16c7e9e402789ddc
https://pubmed.ncbi.nlm.nih.gov/19231176
https://pubmed.ncbi.nlm.nih.gov/19231176
Autor:
Bernd-Michael Löffler, Denise Blum-Kaelin, Hermann Haller, Joon-Keun Park, Henrietta Dehmlow, Bernhard Pilz, Alexander Mullally, Stefan Masur, Anette Fiebeler, Friedrich C. Luft, Dominik N. Müller, Johannes Aebi, Ralf Dechend
Publikováno v:
Hypertension (Dallas, Tex. : 1979). 40(6)
We tested the hypothesis that endothelin-converting enzyme (ECE) inhibition ameliorates end-organ damage in rats harboring both human renin and human angiotensinogen genes (dTGR). Hypertension develops in the animals, and they die by age 7 weeks of h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0af616783ecd1be34bbe093d864c19ce
https://pubmed.ncbi.nlm.nih.gov/12468567
https://pubmed.ncbi.nlm.nih.gov/12468567
Autor:
Gregor Dernick, Hugues Matile, Cyrille Maugeais, Eric J. Niesor, Elisabeth von der Mark, Christine Magg, Georg Schmid, Evelyne Chaput, Denise Blum-Kaelin
Publikováno v:
Atherosclerosis. 213:e5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::250478e8b20b1e0ca4e38f8adb65819a
https://doi.org/10.1016/j.atherosclerosis.2010.07.042
https://doi.org/10.1016/j.atherosclerosis.2010.07.042