A mixed method feasibility and acceptability study of a flexible intervention based on acceptance and commitment therapy for patients with cancer

Autor: François Bourgognon, Denise Bechet, Cécile Huin-Schohn, Aurélia Strelow, Laëtitia Demarche, Mireille Guillou, Virginie Adam, Estelle Fall, Abdou Yacoubou Omorou

Publikováno v: Frontiers in Psychology, Vol 15 (2024)

ProposeThis study aimed to propose an innovative, open, and circular program that combines acceptance and commitment therapy (ACT) and mindfulness practices. We assessed its feasibility, acceptability, and first signs of its effect on psychological w

Externí odkaz: https://doaj.org/article/ce39bd0382214fc8a593405f8317e752

H3K27M induces defective chromatin spread of PRC2-mediated repressive H3K27me2/me3 and is essential for glioma tumorigenesis

Autor: Ashot S. Harutyunyan, Brian Krug, Haifen Chen, Simon Papillon-Cavanagh, Michele Zeinieh, Nicolas De Jay, Shriya Deshmukh, Carol C. L. Chen, Jad Belle, Leonie G. Mikael, Dylan M. Marchione, Rui Li, Hamid Nikbakht, Bo Hu, Gael Cagnone, Warren A. Cheung, Abdulshakour Mohammadnia, Denise Bechet, Damien Faury, Melissa K McConechy, Manav Pathania, Siddhant U. Jain, Benjamin Ellezam, Alexander G. Weil, Alexandre Montpetit, Paolo Salomoni, Tomi Pastinen, Chao Lu, Peter W. Lewis, Benjamin A. Garcia, Claudia L. Kleinman, Nada Jabado, Jacek Majewski

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)

Lysine27-to-methionine mutations in histone H3 genes (H3K27M) occur in a subgroup of gliomas and decrease genome-wide H3K27 trimethylation. Here the authors utilise primary H3K27M tumour lines and isogenic CRISPR-edited controls and show that H3K27M

Externí odkaz: https://doaj.org/article/0beae741fed94f66b31dab929cbfe1ba

H3K27M induces defective chromatin spread of PRC2-mediated repressive H3K27me2/me3 and is essential for glioma tumorigenesis

Autor: Gael Cagnone, Siddhant U. Jain, Warren A. Cheung, Jacek Majewski, Simon Papillon-Cavanagh, Shriya Deshmukh, Hamid Nikbakht, Jad I. Belle, Haifen Chen, Damien Faury, Benjamin Ellezam, Peter W. Lewis, Carol C.L. Chen, Nicolas De Jay, Abdulshakour Mohammadnia, Bo Hu, Melissa K. McConechy, Brian Krug, Dylan M. Marchione, Claudia L. Kleinman, Michele Zeinieh, Chao Lu, Ashot S. Harutyunyan, Tomi Pastinen, Leonie G. Mikael, Benjamin A. Garcia, Manav Pathania, Alexander G. Weil, Nada Jabado, Rui Li, Alexandre Montpetit, Denise Bechet, Paolo Salomoni

Publikováno v: Nature Communications
Nature Communications 10(1), 1262 (2019). doi:10.1038/s41467-019-09140-x
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)

Lys-27-Met mutations in histone 3 genes (H3K27M) characterize a subgroup of deadly gliomas and decrease genome-wide H3K27 trimethylation. Here we use primary H3K27M tumor lines and isogenic CRISPR-edited controls to assess H3K27M effects in vitro and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc8009a4766e296bb95581ac15a67e41
https://pubmed.ncbi.nlm.nih.gov/30890717

Specific detection of methionine 27 mutation in histone 3 variants (H3K27M) in fixed tissue from high-grade astrocytomas

Autor: Caterina Rousso, Keith L. Ligon, Stefan M. Pfister, Steffen Albrecht, Pierre Fiset, Mark W. Kieran, Gerrit H. Gielen, Naciba Benlimane, Torsten Pietsch, Benjamin Ellezam, Peter W. Lewis, Damien Faury, Chao Lu, Denise Bechet, Andrey Korshunov, C. David Allis, Nada Jabado

Publikováno v: Acta Neuropathologica

Studies in pediatric high-grade astrocytomas (HGA) by our group and others have uncovered recurrent somatic mutations affecting highly conserved residues in histone 3 (H3) variants. One of these mutations leads to analogous p.Lys27Met (K27M) mutation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5111de61a972dc4c54a1838e09be8ce5
http://europepmc.org/articles/PMC4201745

Abstract B44: Identification of epigenomic changes induced by H3 K27M mutation in glioblastoma using patient-derived and CRISPR/Cas9 edited cell lines

Autor: Jad Belle, Jacek Majewski, Nada Jabado, Warren A. Cheung, Denise Bechet, Brian Krug, Haifen Chen, Simon Papillon-Cavanagh, Rui Li, Leonie G. Mikael, Tomi Pastinen, Caterina Russo, Ashot S. Harutyunyan, Shriya Deshmukh, Tenzin Gayden, Michele Zeinieh, Nicolas De Jay, Claudia L. Kleinman, Damien Faury

Publikováno v: Cancer Research. 78:B44-B44

Background: Glioblastoma is a grade IV malignant brain tumor with poor prognosis and rapid disease progression. Recurrent somatic mutations in histone H3 genes have been identified in the majority of pediatric glioblastoma cases. The K27M mutation in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ff7fa13b7970c671882e216d32d5e91d
https://doi.org/10.1158/1538-7445.pedca17-b44