Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Denise Barçante Castro-Pinto"'
Autor:
Aurea Echevarria, Grazielle Alves Ribeiro, Leonor L. Leon, Márcia Moreira Berredo-Pinho, Myrtes S. S. Bellieny, Carla Marins Goulart, Leonardo Henrique Ferreira Gomes, Mônica Caroline de Oliveira Campos, Denise Barçante Castro-Pinto
Publikováno v:
Parasitology Research
Drug resistance in protozoan parasites has been associated with the P-glycoprotein (Pgp), an energy-dependent efflux pump that transports substances across the membrane. Interestingly, the genes TcPGP1 and TcPGP2 have been described in Trypanosoma cr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be5a7b8bad2c52aae9021b463228d896
https://doi.org/10.1007/s00436-013-3398-z
https://doi.org/10.1007/s00436-013-3398-z
Autor:
Catarina de Nigris Del Cistia, Marilene M. Canto-Cavalheiro, Leonor L. Leon, Aurea Echevarria, Denise Barçante Castro-Pinto, Raquel Fonseca Rodrigues, Carlos Mauricio R. Sant'Anna, Camilla Moretto dos Reis, Filipa Teixeira, Ana M. Tomás, Helena Castro
Publikováno v:
Bioorganic & Medicinal Chemistry. 20:1760-1766
The biological activities of a series of mesoionic 1,3,4-thiadiazolium-2-aminide derivatives have been studied. The most active compounds (MI-HH; MI-3-OCH(3); MI-4-OCH(3) and MI-4-NO(2)) were evaluated to determine their effect on trypanothione reduc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05c723335aeb780d38466383c56e0400
https://doi.org/10.1016/j.bmc.2012.01.009
https://doi.org/10.1016/j.bmc.2012.01.009
Autor:
Leonor L. Leon, Helene Santos Barbosa, Denise Barçante Castro-Pinto, Maria Aparecida Medeiros Maciel, Solange L. de Castro, Mônica Caroline de Oliveira Campos, Kelly Salomão
Publikováno v:
Parasitology Research. 107:1193-1204
Croton cajucara is a plant found in the Amazon region and is known for its medicinal properties. The effects of the methanolic extract of the stem bark of C. cajucara (MCC) and of the isolated terpenes, trans-dehydrocrotonin (t-DCTN) and acetyl aleur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29f67ae37986ff115167edd0877147ca
https://doi.org/10.1007/s00436-010-1988-6
https://doi.org/10.1007/s00436-010-1988-6
Autor:
Daniela Leite Fabrino, Leonor L. Leon, Thiago Bellato‐Santos, Rômulo José Soares-Bezerra, Liliane Gomes-Silva, Marilene M. Canto-Cavalheiro, Denise Barçante Castro-Pinto, Marcelo Genestra
Publikováno v:
Cell Biochemistry and Function. 26:709-717
Leishmania parasites survive despite exposure to the toxic nitrosative oxidants during phagocytosis by the host cell. In this work, the authors investigated comparatively the resistance of Leishmania amazonensis promastigotes and axenic amastigotes t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5107fd3f3b5d24f00bb619abb12f51d5
https://doi.org/10.1002/cbf.1496
https://doi.org/10.1002/cbf.1496
Autor:
Maria Aparecida Medeiros Maciel, Gérzia C. Machado, Gerson S. Lima, Aurea Echevarria, Denise Barçante Castro-Pinto
Publikováno v:
Phytomedicine : international journal of phytotherapy and phytopharmacology. 22(12)
Leishmaniasis comprises several infectious diseases caused by protozoa parasites of Leishmania genus. In recent years, there has been a growing interest in the therapeutic use of natural products to treat parasitic diseases. Among them Croton cajucar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4210d3f4548eecafddfc72ca5c4d8db8
https://pubmed.ncbi.nlm.nih.gov/26547537
https://pubmed.ncbi.nlm.nih.gov/26547537
Autor:
Leonor L. Leon, Mariana Caldas Waghabi, Leila Mendonça-Lima, Marcelo Genestra, Antonio M. Gonçalves, Catarina de Nigris Del Cistia, Gustavo B. Menezes, Carlos Mauricio R. Sant'Anna, Denise Barçante Castro-Pinto
Publikováno v:
Archives of microbiology. 189(4)
Trypanothione disulfide (T[S]2), an unusual form of glutathione found in parasitic protozoa, plays a crucial role in the regulation of the intracellular thiol redox balance and in the defense against oxidative stress. Trypanothione reductase (TR) is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc869b82c39f38a011c3979099d5ebbf
https://pubmed.ncbi.nlm.nih.gov/18060667
https://pubmed.ncbi.nlm.nih.gov/18060667
Autor:
Rosa M. M. de Léo, Andréa S. Cunha, Marcelo Genestra, Fabiane Pereira Monteiro, Edson L. S. Lima, Denise Barçante Castro-Pinto, Leonor L. Leon
Publikováno v:
Journal of enzyme inhibition and medicinal chemistry. 22(1)
Trypanothione reductase (TR) is a major enzyme in trypanosomatids. Its substrate, trypanothione is a molecule containing a tripeptide (L-glutamic acid-cysteine-glycine) coupled to a polyamine, spermidine. This redox system (TR/Trypanothione) is vital
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85b987c18842aef24a5312b1012a5c76
https://pubmed.ncbi.nlm.nih.gov/17373550
https://pubmed.ncbi.nlm.nih.gov/17373550
Autor:
Denise Barçante Castro-Pinto, Marcelo Genestra, Aurea Echevarria, Leonor L. Leon, Léa Cysne-Finkelstein
Publikováno v:
Journal of enzyme inhibition and medicinal chemistry. 19(1)
The activity of trypanothione reductase in Leishmania amazonensis was evaluated and it was demonstrated that TR is expressed in the soluble fractions of infective promastigotes and amastigotes, while non-infective promastigotes expressed the enzyme a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5835db5a73a95b163b5fbf1962242254
https://pubmed.ncbi.nlm.nih.gov/15202494
https://pubmed.ncbi.nlm.nih.gov/15202494
Autor:
Raquel Ferreira Rodrigues, Carlos Mauricio R. Sant'Anna, Aurea Echevarria, Denise Barçante Castro-Pinto, Leonor L. Leon, Ana M. Tomás, Marilene M. Canto-Cavalheiro
Publikováno v:
Free Radical Biology and Medicine. 53:S116-S117
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::11508181dcaa6d65817f345cc95b5271
https://doi.org/10.1016/j.freeradbiomed.2012.10.286
https://doi.org/10.1016/j.freeradbiomed.2012.10.286