Výsledky vyhledávání - "Denise Appel"

Ubiquitin stimulated reversal of topoisomerase 2 DNA-protein crosslinks by TDP2

Autor: C. Denise Appel, Logan R. Butler, Felipe Cortés-Ledesma, Juno M. Krahn, A.A. Riccio, Jenna A Liebermann, Matthew J. Schellenberg, R. Scott Williams

Publikováno v: Repisalud
Instituto de Salud Carlos III (ISCIII)
Digital.CSIC. Repositorio Institucional del CSIC
instname
Nucleic Acids Res

Tyrosyl-DNA phosphodiesterase 2 (TDP2) reverses Topoisomerase 2 DNA–protein crosslinks (TOP2-DPCs) in a direct-reversal pathway licensed by ZATTZNF451 SUMO2 E3 ligase and SUMOylation of TOP2. TDP2 also binds ubiquitin (Ub), but how Ub regulates TDP

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ef519374a8117e19b5d8918492d5564
http://hdl.handle.net/10261/221300

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Structure of the sirtuin-linked macrodomain SAV0325 from Staphylococcus aureus

Autor: R. Scott Williams, Bret D. Wallace, Geoffrey K. Feld, C. Denise Appel

Publikováno v: Protein Science

Cells use the post-translational modification ADP-ribosylation to control a host of biological activities. In some pathogenic bacteria, an operon-encoded mono-ADP-ribosylation cycle mediates response to host-induced oxidative stress. In this system,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d126613217095ca9ec6a6e5a5275366a

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Reversal of DNA damage induced Topoisomerase 2 DNA–protein crosslinks by Tdp2

Autor: Jason Williams, Lalith Perera, Crystal A. Waters, Brinda Monian, Caroline K. Vilas, Dale A. Ramsden, Matthew J. Schellenberg, R. Scott Williams, C. Denise Appel, Christina N. Strom

Publikováno v: Nucleic Acids Research

Mammalian Tyrosyl-DNA phosphodiesterase 2 (Tdp2) reverses Topoisomerase 2 (Top2) DNA-protein crosslinks triggered by Top2 engagement of DNA damage or poisoning by anticancer drugs. Tdp2 deficiencies are linked to neurological disease and cellular sen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7cc540e9ba6c936c23b168e94a9407d
https://doi.org/10.1093/nar/gkw228

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Tetrameric Ctp1 coordinates DNA binding and bridging in DNA double strand break repair

Autor: Patrick D. Robertson, R. Scott Williams, Michael A. Resnick, Sara N. Andres, C. Denise Appel, James W. Westmoreland, Jessica S. Williams, Yvonne Nguyen

Publikováno v: Nature structural & molecular biology

Ctp1 (also known as CtIP or Sae2) collaborates with Mre11-Rad50-Nbs1 to initiate repair of DNA double-strand breaks (DSBs), but its functions remain enigmatic. We report that tetrameric Schizosaccharomyces pombe Ctp1 contains multivalent DNA-binding

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04a2e4c013bcfa7cd180813db6b84764
http://europepmc.org/articles/PMC4318798

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Narratives on Death and Bereavement From Three South African Cultures: An Exploratory Study

Autor: Denise Appel, Maria Papaikonomou

Publikováno v: Journal of Psychology in Africa. 23:453-458

The study aimed to explore how three culturally diverse South African women (n=3) constructed death and bereavement. Data were qualitatively gathered and thematically analyzed. Findings revealed grand narratives (other than western dominance) on deat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d373cc0a4509a1211a6c613b43728cca
https://doi.org/10.1080/14330237.2013.10820651

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APE2 Zf-GRF facilitates 3'-5' resection of DNA damage following oxidative stress

Autor: R. Scott Williams, Robert E. London, Eugene F. DeRose, C. Denise Appel, Sara N. Andres, Jessica L. Wojtaszek, Timothy Chang, Bret D. Wallace, Geoffrey A. Mueller, Zachary Berman, Shan Yan, Yunfeng Lin

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America. 114(2)

The Xenopus laevis APE2 (apurinic/apyrimidinic endonuclease 2) nuclease participates in 3′-5′ nucleolytic resection of oxidative DNA damage and activation of the ATR-Chk1 DNA damage response (DDR) pathway via ill-defined mechanisms. Here we repor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df21e16ce17e424a2a06eacbb6e61734
https://pubmed.ncbi.nlm.nih.gov/28028224

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Deficiency of terminal ADP-ribose protein glycohydrolase TARG1/C6orf130 in neurodegenerative disease

Publikováno v: The EMBO Journal
EMBO J

Adenosine diphosphate (ADP)-ribosylation is a post-translational protein modification implicated in the regulation of a range of cellular processes. A family of proteins that catalyse ADP-ribosylation reactions are the poly(ADP-ribose) (PAR) polymera

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf237b245362dda22b84fac0f67edcf6

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Mechanism of repair of 5'-topoisomerase II-DNA adducts by mammalian tyrosyl-DNA phosphodiesterase 2

Autor: C. Denise Appel, Patrick D. Robertson, Sanjay Adhikari, R. Scott Williams, Matthew J. Schellenberg, Dale A. Ramsden

Publikováno v: Nature structural & molecular biology

The topoisomerase II (topo II) DNA incision-and-ligation cycle can be poisoned (for example following treatment with cancer chemotherapeutics) to generate cytotoxic DNA double-strand breaks (DSBs) with topo II covalently conjugated to DNA. Tyrosyl-DN

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::476e937264735ab7dc1889cdbf2ae84f
https://pubmed.ncbi.nlm.nih.gov/23211766

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