Zobrazeno 1 - 10
of 99
pro vyhledávání: '"Denise Al Alam"'
Autor:
Laure M.G. Petit, Randa Belgacemi, Julien Ancel, Lynda Saber Cherif, Myriam Polette, Jeanne-Marie Perotin, Nathalie Spassky, Charles Pilette, Denise Al Alam, Gaëtan Deslée, Valérian Dormoy
Publikováno v:
European Respiratory Review, Vol 32, Iss 170 (2023)
Cilia are organelles emanating from the cell surface, consisting of an axoneme of microtubules that extends from a basal body derived from the centrioles. They are either isolated and nonmotile (primary cilia), or grouped and motile (motile cilia). C
Externí odkaz:
https://doaj.org/article/e0fbf611df534e4fb204be9a76171269
Autor:
Soumyaroop Bhattacharya, Jacquelyn A. Myers, Cameron Baker, Minzhe Guo, Soula Danopoulos, Jason R. Myers, Gautam Bandyopadhyay, Stephen T. Romas, Heidie L. Huyck, Ravi S. Misra, Jennifer Dutra, Jeanne Holden-Wiltse, Andrew N. McDavid, John M. Ashton, Denise Al Alam, S. Steven Potter, Jeffrey A. Whitsett, Yan Xu, Gloria S. Pryhuber, Thomas J. Mariani
Publikováno v:
Genes, Vol 15, Iss 3, p 298 (2024)
While animal model studies have extensively defined the mechanisms controlling cell diversity in the developing mammalian lung, there exists a significant knowledge gap with regards to late-stage human lung development. The NHLBI Molecular Atlas of L
Externí odkaz:
https://doaj.org/article/3996ae063b504f2687fa04752f0eeb11
Autor:
Randa Belgacemi, Caroline Cherry, Imad El Alam, Andrew Frauenpreis, Ian Glass, Saverio Bellusci, Soula Danopoulos, Denise Al Alam
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Fibroblast growth factor (FGF) signaling is necessary for proper lung branching morphogenesis, alveolarization, and vascular development. Dysregulation of FGF activity has been implicated in various lung diseases. Recently, we showed that FGF18 promo
Externí odkaz:
https://doaj.org/article/33cd71228f1249e8913affb74fee3d69
Autor:
Feng Gao, Changgong Li, Soula Danopoulos, Denise Al Alam, Neil Peinado, Sha Webster, Zea Borok, GoleNaz Adeli Kohbodi, Saverio Bellusci, Parviz Minoo
Publikováno v:
Cell Reports, Vol 39, Iss 1, Pp 110608- (2022)
Summary: The lung alveolus is lined with alveolar type 1 (AT1) and type 2 (AT2) epithelial cells. During alveologenesis, increasing demand associated with expanding alveolar numbers is met by proliferating progenitor AT2s (pAT2). Little information e
Externí odkaz:
https://doaj.org/article/c2caca6805364138a638e17d7e693f99
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Cystic fibrosis (CF)-related bone disease has emerged as a significant comorbidity of CF and is characterized by decreased bone formation and increased bone resorption. Both osteoblast and osteoclast differentiations are impacted by cystic fibrosis t
Externí odkaz:
https://doaj.org/article/577d821c5fd9461592081e812c559a2c
Autor:
Randa Belgacemi, Soula Danopoulos, Gail Deutsch, Ian Glass, Valérian Dormoy, Saverio Bellusci, Denise Al Alam
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 9, p 5265 (2022)
The Hedgehog (HH) signaling pathway plays an essential role in mouse lung development. We hypothesize that the HH pathway is necessary for branching during human lung development and is impaired in pulmonary hypoplasia. Single-cell, bulk RNA-sequenci
Externí odkaz:
https://doaj.org/article/a516a608ad814e2bba0a81d13d159f9f
Autor:
Sara Taghizadeh, Matthew R. Jones, Ruth Olmer, Saskia Ulrich, Soula Danopoulos, Chengguo Shen, Chaolei Chen, Jochen Wilhelm, Ulrich Martin, Chengshui Chen, Denise Al Alam, Saverio Bellusci
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
The existence during mouse lung development of an embryonic stage temporally and functionally distinct from the subsequent pseudoglandular stage has been proposed but never demonstrated; while studies in human embryonic lung tissue fail to recapitula
Externí odkaz:
https://doaj.org/article/7e864000238f40d8991b1a2b3778caa9
Autor:
Danielle V. Bower, Nick Lansdale, Sonia Navarro, Thai V. Truong, Dan J. Bower, Neil C. Featherstone, Marilyn G. Connell, Denise Al Alam, Mark R. Frey, Le A. Trinh, G. Esteban Fernandez, David Warburton, Scott E. Fraser, Daimark Bennett, Edwin C. Jesudason
Publikováno v:
Biology Open, Vol 6, Iss 10, Pp 1458-1471 (2017)
Branching morphogenesis underlies organogenesis in vertebrates and invertebrates, yet is incompletely understood. Here, we show that the sarco-endoplasmic reticulum Ca2+ reuptake pump (SERCA) directs budding across germ layers and species. Clonal kno
Externí odkaz:
https://doaj.org/article/6dc6a89c9c804d15867c9d3a71b5a831
Publikováno v:
Frontiers in Genetics, Vol 10 (2019)
Fibroblast growth factor 10 (FGF10) plays an important role in mouse lung development, injury, and repair. It is considered the main morphogen driving lung branching morphogenesis in rodents. While many studies have found FGF10 SNPs associated with C
Externí odkaz:
https://doaj.org/article/d1d0c4d0a0d1489ea4c878f41842fa39
Autor:
Matthew R. Jones, Salma Dilai, Arun Lingampally, Cho-Ming Chao, Soula Danopoulos, Gianni Carraro, Regina Mukhametshina, Jochen Wilhelm, Eveline Baumgart-Vogt, Denise Al Alam, Chengshui Chen, Parviz Minoo, Jin San Zhang, Saverio Bellusci
Publikováno v:
Frontiers in Genetics, Vol 9 (2019)
This study demonstrates that FGF10/FGFR2b signaling on distal epithelial progenitor cells, via ß-catenin/EP300, controls, through a comprehensive set of developmental genes, morphogenesis, and differentiation. Fibroblast growth factor (FGF) 10 signa
Externí odkaz:
https://doaj.org/article/047ed13dcfec476eaa31718dbf35d48a