Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Denise A. Santoro"'
Autor:
Ron A. Morena, Nabil Hanna, Braslawsky Gary R, Syed V. S. Kashmiri, Jeffrey Schlom, Paul Chinn, Denise A. Santoro, Timothy Kazules
Publikováno v:
Cancer Biotherapy and Radiopharmaceuticals. 21:106-116
The primary limitation of IgG antibodies for radioimmunotherapy of solid tumors is their prolonged serum half-life, leading to dose-limiting bone marrow toxicity at doses providing inadequate radiation to the tumor. A humanized C(H)2 domain-deleted v
Autor:
Alemseged Truneh, Carl Crysler, Nabil Hanna, Kandasamy Hariharan, Paul R. Dal Monte, Robert C. Gagnon, Preston Hensley, Raymond W. Sweet, Michael L. Doyle, Peter J. Bugelski, Manjula Reddy, Roland A. Newman, Braslawsky Gary R, Michael Brigham-Burke, Reff Mitchell E, Darrel R. Anderson, Denise A. Santoro
Publikováno v:
Clinical Immunology. 98:164-174
Keliximab, a Primatized IgG1 CD4 mAb, was reconfigured to an IgG4 antibody. The gamma4 constant region was further modified by substituting glutamic acid for serine at position 235 in the CH2 domain (IgG4-E), to remove residual binding to Fcgamma rec
Autor:
Paul C. Chinn, Ron A. Morena, Denise A. Santoro, Timothy Kazules, Syed V.S. Kashmiri, Jeffrey Schlom, Nabil Hanna, Gary Braslawsky
Publikováno v:
Cancer Biotherapy & Radiopharmaceuticals; Apr2006, Vol. 21 Issue 2, p106-116, 11p