Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Denise, Tischner"'
Autor:
Malarvizhi Gurusamy, Denise Tischner, Jingchen Shao, Stephan Klatt, Sven Zukunft, Remy Bonnavion, Stefan Günther, Kai Siebenbrodt, Roxane-Isabelle Kestner, Tanja Kuhlmann, Ingrid Fleming, Stefan Offermanns, Nina Wettschureck
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
P2Y10 is a G-protein-coupled receptor that is expressed in CD4 T cells. Here authors show that its ligands, lysophosphatidylserine and ATP, are induced in T cells upon chemokine stimulation and regulate RhoA activation and migration through an autocr
Externí odkaz:
https://doaj.org/article/d43888793ed74435ad7482aecc577779
Autor:
Florian Wanke, Sonja Moos, Andrew L. Croxford, André P. Heinen, Stephanie Gräf, Bettina Kalt, Denise Tischner, Juan Zhang, Isabelle Christen, Julia Bruttger, Nir Yogev, Yilang Tang, Morad Zayoud, Nicole Israel, Khalad Karram, Sonja Reißig, Sonja M. Lacher, Christian Reichhold, Ilgiz A. Mufazalov, Avraham Ben-Nun, Tanja Kuhlmann, Nina Wettschureck, Andreas W. Sailer, Klaus Rajewsky, Stefano Casola, Ari Waisman, Florian C. Kurschus
Publikováno v:
Cell Reports, Vol 18, Iss 5, Pp 1270-1284 (2017)
Arrival of encephalitogenic T cells at inflammatory foci represents a critical step in development of experimental autoimmune encephalomyelitis (EAE), the animal model for multiple sclerosis. EBI2 and its ligand, 7α,25-OHC, direct immune cell locali
Externí odkaz:
https://doaj.org/article/4430b96b5b16407db24119db388b3fa8
Autor:
Lourdes Rocamora-Reverte, Selma Tuzlak, Laura von Raffay, Marcel Tisch, Heidi Fiegl, Mathias Drach, Holger M. Reichardt, Andreas Villunger, Denise Tischner, G. Jan Wiegers
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Activation of the immune system increases systemic adrenal-derived glucocorticoid (GC) levels which downregulate the immune response as part of a negative feedback loop. While CD4+ T cells are essential target cells affected by GC, it is not known wh
Externí odkaz:
https://doaj.org/article/1ff41dd18e2a4e848458c96ff01777d9
Autor:
Verena Labi, Daniela Bertele, Claudia Woess, Denise Tischner, Florian J. Bock, Sven Schwemmers, Heike L. Pahl, Stephan Geley, Mirjam Kunze, Charlotte M. Niemeyer, Andreas Villunger, Miriam Erlacher
Publikováno v:
EMBO Molecular Medicine, Vol 5, Iss 1, Pp 122-136 (2012)
Abstract Anti‐apoptotic Bcl‐2 family members are critical for the regulation of haematopoietic stem and progenitor cell (HSPC) survival. Little is known about the role of their pro‐apoptotic antagonists, i.e. ‘BH3‐only’ proteins, in this
Externí odkaz:
https://doaj.org/article/ebf7c50d150d4e9a8a87fc2714835e25
Autor:
Remy Bonnavion, Denise Tischner, Stephan Klatt, Roxane-Isabelle Kestner, Tanja Kuhlmann, Sven Zukunft, Nina Wettschureck, Stefan Günther, Malarvizhi Gurusamy, Ingrid Fleming, Jingchen Shao, Stefan Offermanns, Kai Siebenbrodt
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
G-protein-coupled receptors (GPCRs), especially chemokine receptors, play a central role in the regulation of T cell migration. Various GPCRs are upregulated in activated CD4 T cells, including P2Y10, a putative lysophospholipid receptor that is offi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3259767c36a2e388934cd5db549ac554
https://doi.org/10.1038/s41467-021-26882-9
https://doi.org/10.1038/s41467-021-26882-9
Autor:
Simone Wüst, Denise Tischner, Michael John, Jan P Tuckermann, Christiane Menzfeld, Uwe-Karsten Hanisch, Jens van den Brandt, Fred Lühder, Holger M Reichardt
Publikováno v:
PLoS ONE, Vol 4, Iss 12, p e8202 (2009)
BACKGROUND: Dissociating glucocorticoid receptor (GR) ligands hold great promise for treating inflammatory disorders since it is assumed that they exert beneficial activities mediated by transrepression but avoid adverse effects of GR action requirin
Externí odkaz:
https://doaj.org/article/9131bf4fc0fc475bbecdc5ffc8b0ca31
Autor:
Klaus Rajewsky, Nina Wettschureck, Stephanie Gräf, Ilgiz A. Mufazalov, Morad Zayoud, Tanja Kuhlmann, Sonja Moos, Denise Tischner, Yilang Tang, Florian C. Kurschus, Andreas W. Sailer, Nir Yogev, Andrew L. Croxford, Avraham Ben-Nun, Julia Bruttger, Bettina Kalt, Sonja M. Lacher, Ari Waisman, Isabelle Christen, Sonja Reißig, André P. Heinen, Khalad Karram, Christian Reichhold, Florian Wanke, Stefano Casola, Nicole Israel, Juan Zhang
Publikováno v:
Cell Reports, Vol 18, Iss 5, Pp 1270-1284 (2017)
Arrival of encephalitogenic T cells at inflammatory foci represents a critical step in development of experimental autoimmune encephalomyelitis (EAE), the animal model for multiple sclerosis. EBI2 and its ligand, 7{alpha},25-OHC, direct immune cell l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7264f423d59d19da8ed1a904ee31b98f
Autor:
S. Classen, Stefan Offermanns, Nina Wettschureck, Mario Looso, Julián Albarrán-Juárez, Jorge Carvalho, Stephan Günther, Pratibha Singh, Denise Tischner, Jens Preussner, Ramesh Chennupati, Harmandeep Kaur
Publikováno v:
Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-1 (2019)
Kaur, H, Carvalho, J, Looso, M, Singh, P, Chennupati, R, Preussner, J, Günther, S, Albarrán-Juárez, J, Tischner, D, Classen, S, Offermanns, S & Wettschureck, N 2019, ' Author Correction : Single-cell profiling reveals heterogeneity and functional patterning of GPCR expression in the vascular system ' Nature Communications, vol. 10, no. 1, pp. 1448 . https://doi.org/10.1038/s41467-019-09334-3
Nature Communications, Vol 10, Iss 1, Pp 1-1 (2019)
Kaur, H, Carvalho, J, Looso, M, Singh, P, Chennupati, R, Preussner, J, Günther, S, Albarrán-Juárez, J, Tischner, D, Classen, S, Offermanns, S & Wettschureck, N 2019, ' Author Correction : Single-cell profiling reveals heterogeneity and functional patterning of GPCR expression in the vascular system ' Nature Communications, vol. 10, no. 1, pp. 1448 . https://doi.org/10.1038/s41467-019-09334-3
G-protein-coupled receptor (GPCR) expression is extensively studied in bulk cDNA, but heterogeneity and functional patterning of GPCR expression in individual vascular cells is poorly understood. Here, we perform a microfluidic-based single-cell GPCR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::221869f1f8b374cf13c864031850747c
https://pubmed.ncbi.nlm.nih.gov/28621310
https://pubmed.ncbi.nlm.nih.gov/28621310
Autor:
Christiane Menzfeld, Alexander Götz, Peter Teismann, Denise Tischner, Tommy Regen, Wolfgang Brück, Thomas Herdegen, Martin S. Weber, Philippe Boutin, Sandra Ribes, Shlomo Rotshenker, Michael John, Vanessa Bremes, Angela Borisch, Tobias Pukrop, Jürgen Wienands, Konstantin Neumann, Roland Nau, Helmut Kettenmann, Vicky Waetzig, Fred Lühder, Uwe-Karsten Hanisch, Hana Janova, Iain R. Greig, Alexander Mildner, Denise van Rossum, Holger M. Reichardt, Jörg Scheffel, Michael Müller, Marco Prinz
Publikováno v:
Glia. 63:1083-1099
The putative protein tyrosine kinase (PTK) inhibitor tyrphostin AG126 has proven beneficial in various models of inflammatory disease. Yet molecular targets and cellular mechanisms remained enigmatic. We demonstrate here that AG126 treatment has bene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::06ae829bc2f7b8151092d31202d6404a
https://doi.org/10.1002/glia.22803
https://doi.org/10.1002/glia.22803
Autor:
Simon Classen, Jorge Carvalho, Stefan Günther, Stefan Offermanns, Denise Tischner, Julián Albarrán-Juárez, Jens Preussner, Mario Looso, Ramesh Chennupati, Harmandeep Kaur, Nina Wettschureck, Pratibha Singh
Publikováno v:
Nature Communications
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
G-protein-coupled receptor (GPCR) expression is extensively studied in bulk cDNA, but heterogeneity and functional patterning of GPCR expression in individual vascular cells is poorly understood. Here, we perform a microfluidic-based single-cell GPCR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1eb4f1b40a15f5515b89e2529a79035
https://doi.org/10.1038/ncomms15700
https://doi.org/10.1038/ncomms15700