Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Denise, Skrombolas"'
Publikováno v:
J Interferon Cytokine Res
Cytokines are powerful mediators of immune responses and some, such as interleukin-2 (IL-2), have achieved dramatic responses as cancer immunotherapies. Unfortunately, systemic administration often results in deleterious side effects, prompting explo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ac633e3b06b48aa47f9775e257d51e0
https://doi.org/10.1089/jir.2022.0043
https://doi.org/10.1089/jir.2022.0043
Interleukin-12 (IL-12) is a pleiotropic cytokine that has profound effects on many aspects of cell-mediated responses and can enhance antitumor responses in experimental models. IL-12 has been tested clinically, however, side-effects have limited its
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d4497029d4401b6803175b6c3dd6e18
https://europepmc.org/articles/PMC6479256/
https://europepmc.org/articles/PMC6479256/
Publikováno v:
The Journal of Immunology. 204:246.9-246.9
Cytokines are potent immune mediators and play a crucial role in the differentiation and activation of effector CD8 T cells which are critical in anti-tumor responses. Here we tested the ability of IL-2, IL-12, and IL-18 to drive expression of gamma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9137b3cfbfc03b664fc6666c7eb4c1f9
https://doi.org/10.4049/jimmunol.204.supp.246.9
https://doi.org/10.4049/jimmunol.204.supp.246.9
Publikováno v:
Journal of Interferon & Cytokine Research. 35:690-697
Interleukin-12 (IL-12), a potent inducer of interferon gamma (IFNγ), is a heterodimeric protein consisting of p40 and p35 subunits whose expression is regulated independently. IL-12 is part of a cytokine family (currently consisting of IL-12, IL-23,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d12ecadebc190e9ab050530c6e944c4
https://doi.org/10.1089/jir.2014.0176
https://doi.org/10.1089/jir.2014.0176
Autor:
Denise Skrombolas, John G. Frelinger
Publikováno v:
Expert Review of Clinical Immunology. 10:207-217
Interleukin-2 (IL-2) is a cytokine with pleiotropic effects on the immune system. Systemic IL-2 treatment has produced durable responses in melanoma and renal cancer patients, but unfortunately this is effective only in a fraction of patients. Moreov
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a678d7f1b34ddc3cb7cdbf8ee82d4354
https://doi.org/10.1586/1744666x.2014.875856
https://doi.org/10.1586/1744666x.2014.875856
Autor:
Abigail Sedlacek, Denise Skrombolas, Joanne Y.H. Lim, John G. Frelinger, Scott A. Gerber, Elizabeth W. Sorensen, Edith M. Lord
Publikováno v:
Immunology
The tumour microenvironment is complex containing not only neoplastic cells but also a variety of host cells. The heterogeneous infiltrating immune cells include subsets of cells with opposing functions, whose activities are mediated either directly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0985fed5dce449e5bf3e2c3973e33600
Autor:
John G. Frelinger, Abigail Sedlacek, Denise Skrombolas, John A. Puskas, Mark A. Sullivan, Edith M. Lord
Publikováno v:
Immunology. 133:206-220
The ability to alter the cytokine microenvironment has the potential to shape immune responses in many physiological settings, including the immunotherapy of tumours. We set out to develop a general approach in which cytokines could be functionally a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::27edc885007d2757d4ef3c1795d41cd9
https://doi.org/10.1111/j.1365-2567.2011.03428.x
https://doi.org/10.1111/j.1365-2567.2011.03428.x
Autor:
Lucinda L. Hensley, Thomas H. Kawula, Michael D. Valentino, Denise Skrombolas, John G. Frelinger, Jeffrey A. Frelinger, Pamela L. McPherson, Matthew D. Woolard
Publikováno v:
Molecular Immunology. 46:1830-1838
Francisella tularensis is a Gram-negative intracellular bacterium that is the causative agent of tularemia. Small mammals such as rodents and rabbits, as well as some biting arthropods, serve as the main vectors for environmental reservoirs of F. tul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2aee0c0fd1cd009bdef953d0020949ec
https://doi.org/10.1016/j.molimm.2009.01.008
https://doi.org/10.1016/j.molimm.2009.01.008
Autor:
John G. Frelinger, Michelle Dziejman, Thomas H. Kawula, Michael D. Valentino, Denise Skrombolas, C. Siddiq Abdul-Alim, Zachary J. Maben, Edith M. Lord, Jeffrey A. Frelinger, Lucinda L. Hensley
Epitopes are a hallmark of the antigen specific immune response. The identification and characterization of epitopes is essential for modern immunologic studies, from investigating cellular responses against tumors to understanding host/pathogen inte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a4674b19d5ecbe5e623ae36eef3c5cb
https://europepmc.org/articles/PMC3195951/
https://europepmc.org/articles/PMC3195951/
Autor:
John, Puskas, Denise, Skrombolas, Abigail, Sedlacek, Edith, Lord, Mark, Sullivan, John, Frelinger
Publikováno v:
Immunology. 133(2)
The ability to alter the cytokine microenvironment has the potential to shape immune responses in many physiological settings, including the immunotherapy of tumours. We set out to develop a general approach in which cytokines could be functionally a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::15aca4b3379f23dd90a9763de8784ee4
https://pubmed.ncbi.nlm.nih.gov/21426339
https://pubmed.ncbi.nlm.nih.gov/21426339