Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Denisa Komůrková"'
Publikováno v:
Life, Vol 11, Iss 7, p 669 (2021)
METTL16 methyltransferase is responsible for the methylation of N6-adenosine (m6A) in several RNAs. In mouse cells, we showed that the nuclear distribution of METTL16 is cell cycle-specific. In the G1/S phases, METTL16 accumulates to the nucleolus, w
Externí odkaz:
https://doaj.org/article/23039bf3561b4c57b5109e6b130020d4
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 4, p 1995 (2021)
G-quadruplexes (G4s) are four-stranded helical structures that regulate several nuclear processes, including gene expression and telomere maintenance. We observed that G4s are located in GC-rich (euchromatin) regions and outside the fibrillarin-posit
Externí odkaz:
https://doaj.org/article/104133a013634b7a9e7681f68e9cfc4c
Autor:
Alena Svobodová Kovaříková, Lenka Stixová, Aleš Kovařík, Denisa Komůrková, Soňa Legartová, Paolo Fagherazzi, Eva Bártová
Publikováno v:
Cells, Vol 9, Iss 2, p 360 (2020)
The DNA damage response is mediated by both DNA repair proteins and epigenetic markers. Here, we observe that N6-methyladenosine (m6A), a mark of the epitranscriptome, was common in RNAs accumulated at UV-damaged chromatin; however, inhibitors of RNA
Externí odkaz:
https://doaj.org/article/0f0ff6109b3c4db9b21e76b0ad6363a6
Granulocyte Colony-Stimulating Factor in the Treatment of Acute Radiation Syndrome: A Concise Review
Publikováno v:
Molecules, Vol 19, Iss 4, Pp 4770-4778 (2014)
This article concisely summarizes data on the action of one of the principal and best known growth factors, the granulocyte colony-stimulating factor (G-CSF), in a mammalian organism exposed to radiation doses inducing acute radiation syndrome. Highl
Externí odkaz:
https://doaj.org/article/050490a6afa64f3aa0e07a38f53926ff
Publikováno v:
Molecules, Vol 17, Iss 5, Pp 5615-5625 (2012)
The presented review summarizes experimental data obtained with a mouse model when investigating the relationship between inhibition of prostaglandin production and hematopoiesis. While prostaglandin E2 acts in a negative feedback control of myelopoi
Externí odkaz:
https://doaj.org/article/97c5e0feb494497d97b54c9529749361
Publikováno v:
Life
Volume 11
Issue 7
Life, Vol 11, Iss 669, p 669 (2021)
Volume 11
Issue 7
Life, Vol 11, Iss 669, p 669 (2021)
METTL16 methyltransferase is responsible for the methylation of N6-adenosine (m6A) in several RNAs. In mouse cells, we showed that the nuclear distribution of METTL16 is cell cycle-specific. In the G1/S phases, METTL16 accumulates to the nucleolus, w
Publikováno v:
Chromosome Research. 27:41-55
Repair of ribosomal DNA (rDNA) is a very important nuclear process due to the most active transcription of ribosomal genes. Proper repair of rDNA is required for physiological biogenesis of ribosomes. Here, we analyzed the epigenetics of the DNA dama
Autor:
Lenka Štefančíková, Karel J. Angelis, Denisa Komůrková, Michal Hofer, Bořivoj Klejdus, Iva Falková, Ladislav Dušek, Martin Falk, Lenka Weiterová, Alena Bačíková, Štefan Galbavý, Eva Pagáčová, Stanislav Kozubek
Publikováno v:
Journal of Medicinal Chemistry. 59:3003-3017
Amifostine protects normal cells from DNA damage induction by ionizing radiation or chemotherapeutics, whereas cancer cells typically remain uninfluenced. While confirming this phenomenon, we have revealed by comet assay and currently the most sensit
Publikováno v:
Purinergic Signalling. 11:79-85
Adenosine A3 receptor knockout (A3AR KO) mice and their wild-type (WT) counterparts were compared from the point of view of their abilities to survive exposures to lethal doses of γ-radiation belonging to the range of radiation doses inducing the bo
Publikováno v:
Open Life Sciences, Vol 9, Iss 6, Pp 642-646 (2014)
Combined approaches to the treatment of acute radiation disease are preferred to single-agent therapies due to proven or anticipated better outcomes comprising increased therapeutic efficacy and decreased incidence of undesirable side effects. Our st