Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Denisa Kirdajova"'
Autor:
Martina Chmelova, Peter Androvic, Denisa Kirdajova, Jana Tureckova, Jan Kriska, Lukas Valihrach, Miroslava Anderova, Lydia Vargova
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 17 (2023)
IntroductionModification of the extracellular matrix (ECM) is one of the major processes in the pathology of brain damage following an ischemic stroke. However, our understanding of how age-related ECM alterations may affect stroke pathophysiology an
Externí odkaz:
https://doaj.org/article/6b7a09d149be46f69fa671ac67a7ed87
Autor:
Tereza Filipi, Zuzana Matusova, Pavel Abaffy, Ondrej Vanatko, Jana Tureckova, Sarka Benesova, Monika Kubiskova, Denisa Kirdajova, Jakub Zahumensky, Lukas Valihrach, Miroslava Anderova
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-15 (2023)
Abstract The role of glia in amyotrophic lateral sclerosis (ALS) is undeniable. Their disease-related activity has been extensively studied in the spinal cord, but only partly in the brain. We present herein a comprehensive study of glia in the corte
Externí odkaz:
https://doaj.org/article/a35f615333f640c2a67600c1ef38b273
Autor:
Petra Sucha, Zuzana Hermanova, Martina Chmelova, Denisa Kirdajova, Sara Camacho Garcia, Valeria Marchetti, Ivan Vorisek, Jana Tureckova, Eyar Shany, Daniel Jirak, Miroslava Anderova, Lydia Vargova
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 16 (2022)
IntroductionAstrocytic Aquaporin 4 (AQP4) and Transient receptor potential vanilloid 4 (TRPV4) channels form a functional complex that likely influences cell volume regulation, the development of brain edema, and the severity of the ischemic injury.
Externí odkaz:
https://doaj.org/article/5c81345844e6487e8f7c5f6fd2302364
Autor:
Brenan Cullimore, Jackson Baumann, Christopher N Rudzitis, Andrew O Jo, Denisa Kirdajova, David Križaj
Publikováno v:
Neural Regeneration Research, Vol 18, Iss 5, Pp 1031-1032 (2023)
Externí odkaz:
https://doaj.org/article/0353d7fb69d64c3f89e493b69b5f8bf7
Autor:
Jan Kriska, Lucie Janeckova, Denisa Kirdajova, Pavel Honsa, Tomas Knotek, David Dzamba, Denisa Kolenicova, Olena Butenko, Martina Vojtechova, Martin Capek, Zbynek Kozmik, Makoto Mark Taketo, Vladimir Korinek, Miroslava Anderova
Publikováno v:
Frontiers in Neuroscience, Vol 15 (2021)
Modulating endogenous regenerative processes may represent a suitable treatment for central nervous system (CNS) injuries, such as stroke or trauma. Neural stem/progenitor cells (NS/PCs), which naturally reside in the subventricular zone (SVZ) of the
Externí odkaz:
https://doaj.org/article/abcd8bb230064c7b80ad86ff6baa7608
Autor:
Peter Androvic, Denisa Kirdajova, Jana Tureckova, Daniel Zucha, Eva Rohlova, Pavel Abaffy, Jan Kriska, Martin Valny, Miroslava Anderova, Mikael Kubista, Lukas Valihrach
Publikováno v:
Cell Reports, Vol 31, Iss 11, Pp 107777- (2020)
Summary: Ischemic stroke is a well-recognized disease of aging, yet it is unclear how the age-dependent vulnerability occurs and what are the underlying mechanisms. To address these issues, we perform a comprehensive RNA-seq analysis of aging, ischem
Externí odkaz:
https://doaj.org/article/48606988946442b78008c3d7458dfed8
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 10 (2016)
The tamoxifen-inducible Cre-loxP system is widely used to overcome gene targeting pre-adult lethality, to modify a specific cell population at desired time-points, and to visualize and trace cells in fate-mapping studies. In this study we focused on
Externí odkaz:
https://doaj.org/article/c52bd88354864a4aade3e5a3f9640a1b
Autor:
Daniel Zucha, Pavel Abaffy, Denisa Kirdajova, Daniel Jirak, Miroslava Anderova, Mikael Kubista, Lukas Valihrach
The role of non-neuronal cells in the resolution of cerebral ischemia remains to be fully understood. To decode key cellular processes that occur after ischemia, we performed spatial and single-cell transcriptomic profiling of mouse brain tissue duri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::81a20a224de6386745093ea5f774095c
https://doi.org/10.1101/2023.03.28.534553
https://doi.org/10.1101/2023.03.28.534553
Autor:
Lucie Janeckova, Tomas Knotek, Jan Kriska, Zuzana Hermanova, Denisa Kirdajova, Jan Kubovciak, Linda Berkova, Jana Tureckova, Sara Camacho Garcia, Katerina Galuskova, Michal Kolar, Miroslava Anderova, Vladimir Korinek
Glia cells expressing neuron-glial antigen 2 (NG2) play a critical role as oligodendrocyte precursor cells (OPCs) in the healthy brain; however, their differentiation potential after ischemic injury remains an unresolved question. Here, we aimed to e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f536c10b250d63929d23b53d684892cc
https://doi.org/10.1101/2023.02.20.529180
https://doi.org/10.1101/2023.02.20.529180
Autor:
Miroslava Anderova, Denisa Kirdajova
Publikováno v:
Current Opinion in Pharmacology. 50:53-60
NG2 cells, which comprise a cycling population of glial cells, appear in the early phases of development and are present in the adult central nervous system. When a specific subpopulation of NG2 cells give rise to myelinating oligodendrocytes, they a