Výsledky vyhledávání - "Denisa D Mateus"

Akademický článek

The yeast PNC1 longevity gene is up-regulated by mRNA mistranslation.

Autor: Raquel M Silva, Iven C N Duarte, João A Paredes, Tatiana Lima-Costa, Michel Perrot, Hélian Boucherie, Brian J Goodfellow, Ana C Gomes, Denisa D Mateus, Gabriela R Moura, Manuel A S Santos

Publikováno v: PLoS ONE, Vol 4, Iss 4, p e5212 (2009)

Translation fidelity is critical for protein synthesis and to ensure correct cell functioning. Mutations in the protein synthesis machinery or environmental factors that increase synthesis of mistranslated proteins result in cell death and degenerati

Externí odkaz: https://doaj.org/article/943e46601d564f488bffc94f1ed080f8

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Akademický článek

A genetic code alteration is a phenotype diversity generator in the human pathogen Candida albicans.

Autor: Isabel Miranda, Rita Rocha, Maria C Santos, Denisa D Mateus, Gabriela R Moura, Laura Carreto, Manuel A S Santos

Publikováno v: PLoS ONE, Vol 2, Iss 10, p e996 (2007)

BACKGROUND: The discovery of genetic code alterations and expansions in both prokaryotes and eukaryotes abolished the hypothesis of a frozen and universal genetic code and exposed unanticipated flexibility in codon and amino acid assignments. It is n

Externí odkaz: https://doaj.org/article/411fccf8421b484c9e2697f4f4b3301a

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Codon misreading tRNAs promote tumor growth in mice

Autor: Patrícia Oliveira, Renata Bordeira-Carriço, Carla Oliveira, Rui Vitorino, Joana Carvalho, A. Sofia Varanda, Mafalda Azevedo, Fábio Trindade, Fátima Carneiro, Nuno Mendes, Denisa D. Mateus, Marta Pinto, Manuel A. S. Santos, Mafalda Santos, Patricia M. Pereira

Publikováno v: Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP

Deregulation of tRNAs, aminoacyl-tRNA synthetases and tRNA modifying enzymes are common in cancer, raising the hypothesis that protein synthesis efficiency and accuracy (mistranslation) are compromised in tumors. We show here that human colon tumors

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1860f1dc8dfee5d0cef19ec30c0c4c5
http://hdl.handle.net/10773/27792

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A Rab3a-dependent complex essential for lysosome positioning and plasma membrane repair

Autor: Inês B. Santarino, Lília Espada, Cristina Escrevente, José S. Ramalho, Duarte C. Barral, Otilia V. Vieira, Denisa D. Mateus, Xavier Michelet, Michael B. Brenner, Marisa Encarnação, Victor W. Hsu

Publikováno v: The Journal of Cell Biology

Encarnação et al. show that Rab3a, together with its newly identified effector NMHC IIA, mediates the positioning of peripheral lysosomes in nonsecretory cells, thereby promoting lysosome exocytosis and plasma membrane repair.
Lysosome exocyto

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7486cc99104135ca4f7e914b09970c5

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Finding and tracing human MSC in 3D microenvironments with the photoconvertible protein Dendra2

Autor: Maria Gomez-Lazaro, David B. Gomes, Carla M. Oliveira, Cristina C. Barrias, Denisa D. Mateus, Hugo R. Caires, Carla Oliveira, Catarina R. Almeida, Mário A. Barbosa

Publikováno v: Scientific Reports

Mesenchymal Stem/Stromal Cells (MSC) are a promising cell type for cell-based therapies - from tissue regeneration to treatment of autoimmune diseases - due to their capacity to migrate to damaged tissues, to differentiate in different lineages and t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6c702aa04038892bf148d7377790bcb
https://pubmed.ncbi.nlm.nih.gov/25974085

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Rescue of wild-type E-cadherin expression from nonsense-mutated cancer cells by a suppressor-tRNA

Autor: Manuel A. S. Santos, Denisa D. Mateus, Renata Bordeira-Carriço, Ana Paula Pêgo, Hugo Pinheiro, Daniel Ferreira, Carla Oliveira

Publikováno v: Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP

Hereditary diffuse gastric cancer (HDGC) syndrome, although rare, is highly penetrant at an early age, and is severe and incurable because of ineffective screening tools and therapy. Approximately 45% of HDGC families carry germline CDH1/E-cadherin a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e72380a58830d14c8897b7f7ca56ef9e
http://hdl.handle.net/10773/18869

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Molecular reconstruction of a fungal genetic code alteration

Autor: Manuel A. S. Santos, Denisa D. Mateus, João A. Paredes, Yaiza Español, Lluís Ribas de Pouplana, Gabriela Moura

Publikováno v: Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP

Fungi of the CTG clade translate the Leu CUG codon as Ser. This genetic code alteration is the only eukaryotic sense-to-sense codon reassignment known to date, is mediated by an ambiguous serine tRNA (tRNACAG(Ser)), exposes unanticipated flexibility

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2c915ace8c3bf2ac7e244ef97f104bd
https://europepmc.org/articles/PMC4111736/

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A genetic code alteration is a phenotype diversity generator in the human pathogen Candida albicans

Autor: Maria C. Santos, Rita Rocha, Isabel M. Miranda, Gabriela Moura, Laura Carreto, Manuel A. S. Santos, Denisa D. Mateus

Publikováno v: PLoS ONE, Vol 2, Iss 10, p e996 (2007)
PLoS ONE
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP

Background The discovery of genetic code alterations and expansions in both prokaryotes and eukaryotes abolished the hypothesis of a frozen and universal genetic code and exposed unanticipated flexibility in codon and amino acid assignments. It is no

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b05ddc57f2a5c0314c732bd8446396f4
http://hdl.handle.net/10773/27675

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The Yeast PNC1 Longevity Gene Is Up-Regulated by mRNA Mistranslation

Autor: Denisa D. Mateus, Iven C. N. Duarte, Michel Perrot, Brian J. Goodfellow, João A. Paredes, Manuel A. S. Santos, Ana C. Gomes, Gabriela Moura, Raquel M. Silva, Hélian Boucherie, Tatiana Lima-Costa

Publikováno v: Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
PLoS ONE
PLoS ONE, Vol 4, Iss 4, p e5212 (2009)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0398b78ca926698bccf1e363acdd1e43
https://doi.org/10.1371/journal.pone.0005212

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Akademický článek

Identification and Characterization of Non- Saccharomyces Species Isolated from Port Wine Spontaneous Fermentations.

Autor: Mateus D; Genomics Unit, Biocant-Biotechnology Innovation Center, Biocant Park, Núcleo 04 Lote 3, 3060-197 Cantanhede, Portugal., Sousa S; Genomics Unit, Biocant-Biotechnology Innovation Center, Biocant Park, Núcleo 04 Lote 3, 3060-197 Cantanhede, Portugal., Coimbra C; Ângelo Coimbra, S.A., Zona Industrial Maia, Sector IV Moreira, 4470-460 Maia, Portugal., S Rogerson F; Symington Family Estates, Vinhos S.A. Travessa Barão de Forrester 86, Apartado 26, 4431-901 Vila Nova de Gaia, Portugal., Simões J; Genomics Unit, Biocant-Biotechnology Innovation Center, Biocant Park, Núcleo 04 Lote 3, 3060-197 Cantanhede, Portugal.

Publikováno v: Foods (Basel, Switzerland) [Foods] 2020 Jan 23; Vol. 9 (2). Date of Electronic Publication: 2020 Jan 23.

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