Zobrazeno 1 - 10
of 204
pro vyhledávání: '"Denis Thieffry"'
Autor:
Ozge Saatci, Rashedul Alam, Kim-Tuyen Huynh-Dam, Aynur Isik, Meral Uner, Nevin Belder, Pelin Gulizar Ersan, Unal Metin Tokat, Burge Ulukan, Metin Cetin, Kubra Calisir, Mustafa Emre Gedik, Hilal Bal, Ozlem Sener Sahin, Yasser Riazalhosseini, Denis Thieffry, Daniel Gautheret, Besim Ogretmen, Sercan Aksoy, Aysegul Uner, Aytekin Akyol, Ozgur Sahin
Publikováno v:
Cell Death and Disease, Vol 15, Iss 6, Pp 1-14 (2024)
Abstract Tamoxifen has been the mainstay therapy to treat early, locally advanced, and metastatic estrogen receptor-positive (ER + ) breast cancer, constituting around 75% of all cases. However, the emergence of resistance is common, necessitating th
Externí odkaz:
https://doaj.org/article/736322c0c13e4be88e8c36818fc7c5ab
Autor:
Karla Fabiola Corral-Jara, Camille Chauvin, Wassim Abou-Jaoudé, Maximilien Grandclaudon, Aurélien Naldi, Vassili Soumelis, Denis Thieffry
Publikováno v:
Molecular Biomedicine, Vol 2, Iss 1, Pp 1-16 (2021)
Abstract Interleukins (IL)-17A and F are critical cytokines in anti-microbial immunity but also contribute to auto-immune pathologies. Recent evidence suggests that they may be differentially produced by T-helper (Th) cells, but the underlying mechan
Externí odkaz:
https://doaj.org/article/12305458a27c4a008a2cff8ad8d21439
Autor:
Gautier Stoll, Aurélien Naldi, Vincent Noël, Eric Viara, Emmanuel Barillot, Guido Kroemer, Denis Thieffry, Laurence Calzone
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
Mathematical modeling aims at understanding the effects of biological perturbations, suggesting ways to intervene and to reestablish proper cell functioning in diseases such as cancer or in autoimmune disorders. This is a difficult task for obvious r
Externí odkaz:
https://doaj.org/article/f02489663d454c70affc8aba62e58595
Autor:
Laura Cantini, Pooya Zakeri, Celine Hernandez, Aurelien Naldi, Denis Thieffry, Elisabeth Remy, Anaïs Baudot
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Advances in omics technology have resulted in the generation of multi-view data for cancer samples. Here, the authors compare dimensionality reduction techniques using simulated and TCGA data and identify the features of the methods with superior per
Externí odkaz:
https://doaj.org/article/46bcfde47530473dae0c303f24558469
Publikováno v:
Frontiers in Genetics, Vol 12 (2021)
Networks are powerful tools to represent and investigate biological systems. The development of algorithms inferring regulatory interactions from functional genomics data has been an active area of research. With the advent of single-cell RNA-seq dat
Externí odkaz:
https://doaj.org/article/126b9198d38241a5b2ae694c15aa69ed
Autor:
Walter Santana-Garcia, Maria Rocha-Acevedo, Lucia Ramirez-Navarro, Yvon Mbouamboua, Denis Thieffry, Morgane Thomas-Chollier, Bruno Contreras-Moreira, Jacques van Helden, Alejandra Medina-Rivera
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 17, Iss , Pp 1415-1428 (2019)
Gene regulatory regions contain short and degenerated DNA binding sites recognized by transcription factors (TFBS). When TFBS harbor SNPs, the DNA binding site may be affected, thereby altering the transcriptional regulation of the target genes. Such
Externí odkaz:
https://doaj.org/article/440bf9b4109f479b801230395cb4a6a1
Autor:
Andrea Checcoli, Jonathan G. Pol, Aurelien Naldi, Vincent Noel, Emmanuel Barillot, Guido Kroemer, Denis Thieffry, Laurence Calzone, Gautier Stoll
Publikováno v:
Frontiers in Physiology, Vol 11 (2020)
As opposed to the standard tolerogenic apoptosis, immunogenic cell death (ICD) constitutes a type of cellular demise that elicits an adaptive immune response. ICD has been characterized in malignant cells following cytotoxic interventions, such as ch
Externí odkaz:
https://doaj.org/article/d7e163cf08bf4350ab9f5bf2ad1eb364
Publikováno v:
Frontiers in Physiology, Vol 11 (2020)
At the crossroad between biology and mathematical modeling, computational systems biology can contribute to a mechanistic understanding of high-level biological phenomenon. But as knowledge accumulates, the size and complexity of mathematical models
Externí odkaz:
https://doaj.org/article/95da829ca53b483285f0ca1a6cc14733
Autor:
Sarah M Keating, Dagmar Waltemath, Matthias König, Fengkai Zhang, Andreas Dräger, Claudine Chaouiya, Frank T Bergmann, Andrew Finney, Colin S Gillespie, Tomáš Helikar, Stefan Hoops, Rahuman S Malik‐Sheriff, Stuart L Moodie, Ion I Moraru, Chris J Myers, Aurélien Naldi, Brett G Olivier, Sven Sahle, James C Schaff, Lucian P Smith, Maciej J Swat, Denis Thieffry, Leandro Watanabe, Darren J Wilkinson, Michael L Blinov, Kimberly Begley, James R Faeder, Harold F Gómez, Thomas M Hamm, Yuichiro Inagaki, Wolfram Liebermeister, Allyson L Lister, Daniel Lucio, Eric Mjolsness, Carole J Proctor, Karthik Raman, Nicolas Rodriguez, Clifford A Shaffer, Bruce E Shapiro, Joerg Stelling, Neil Swainston, Naoki Tanimura, John Wagner, Martin Meier‐Schellersheim, Herbert M Sauro, Bernhard Palsson, Hamid Bolouri, Hiroaki Kitano, Akira Funahashi, Henning Hermjakob, John C Doyle, Michael Hucka, SBML Level 3 Community members
Publikováno v:
Molecular Systems Biology, Vol 16, Iss 8, Pp n/a-n/a (2020)
Abstract Systems biology has experienced dramatic growth in the number, size, and complexity of computational models. To reproduce simulation results and reuse models, researchers must exchange unambiguous model descriptions. We review the latest edi
Externí odkaz:
https://doaj.org/article/86e517962df24b21af078b7f951f7487
Autor:
Darely Y. Gutiérrez-Reyna, Alejandra Cedillo-Baños, Linda A. Kempis-Calanis, Oscar Ramírez-Pliego, Lisa Bargier, Denis Puthier, Jose D. Abad-Flores, Morgane Thomas-Chollier, Denis Thieffry, Alejandra Medina-Rivera, Salvatore Spicuglia, Maria A. Santana
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Neonates are highly susceptible to intracellular pathogens, leading to high morbidity and mortality rates. CD8+ T lymphocytes are responsible for the elimination of infected cells. Understanding the response of these cells to normal and high stimulat
Externí odkaz:
https://doaj.org/article/8c177a28a4f942e9a298502304fb2cdd