Marek's disease herpesvirus: a model of vaccine-dependent adaptation

Autor: Ginette, Dambrine, Jennifer, Labaille, Élodie, Boissel, Catherine, Dupuy, Denis, Rasschaert

Publikováno v: Virologie (Montrouge, France). 20(5)

Marek's disease (MD) virus (MDV) is an alphaherpesvirus that causes a rapid-onset T-cell lymphoma in chickens. In order to preserve the viability of poultry industry, non sterilizing vaccines have been used since fifty years, preventing lymphoma deve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3f6606664e6c36b5a99430ab21e009a2
https://pubmed.ncbi.nlm.nih.gov/32260024

Hyperediting by ADAR1 of a new herpesvirus lncRNA during the lytic phase of the oncogenic Marek’s disease virus

Autor: Thomas Figueroa, Denis Rasschaert, Damien Coupeau, Imane Boumart

Publikováno v: Journal of General Virology. 97:2973-2988

Marek’s disease virus, or Gallid herpesvirus 2 (GaHV-2), is an avian alphaherpesvirus that induces T-cell lymphoma in chickens. During transcriptomic studies of the RL region of the genome, we characterized the 7.5 kbp gene of the ERL lncRNA (edite

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f58c3f8274828b4bd89ff61aff3b0a6
https://doi.org/10.1099/jgv.0.000606

GaHV-2 ICP22 protein is expressed from a bicistronic transcript regulated by three GaHV-2 microRNAs

Autor: Ginette Dambrine, Thomas Figueroa, Benoît Muylkens, Srdan Pejakovic, Denis Rasschaert, Imane Boumart, Catherine Dupuy

Publikováno v: Journal of General Virology
Journal of General Virology, Microbiology Society, 2018, 99 (9), pp.1286-1300. ⟨10.1099/jgv.0.001124⟩
Boumart, I, Figueroa, T, Dambrine, G, Muylkens, B, Pejaković, S, Rasschaert, D & Dupuy, C 2018, ' GaHV-2 ICP22 protein is expressed from a bicistronic transcript regulated by three GaHV-2 microRNAs ', The Journal of general virology, vol. 99, no. 9, 001124, pp. 1286-1300 . https://doi.org/10.1099/jgv.0.001124

International audience; Herpesviruses have a lifecycle consisting of successive lytic, latent and reactivation phases. Only three infected cell proteins (ICPs) have been described for the oncogenic Marek's disease virus (or Gallid herpes virus 2, GaH

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97dc6b248b48b9037e654581c6487f08
https://pubmed.ncbi.nlm.nih.gov/30067174

The Oncogenic MicroRNA OncomiR-21 Overexpressed during Marek's Disease Lymphomagenesis Is Transactivated by the Viral Oncoprotein Meq

Autor: Gregoire Stik, Sébastien Pfeffer, Denis Rasschaert, Ginette Dambrine

Publikováno v: Journal of Virology
Journal of Virology, American Society for Microbiology, 2013, 87 (1), pp.80-93. ⟨10.1128/JVI.02449-12⟩

Gallid herpesvirus 2 (GaHV-2) is an oncogenic herpesvirus that causes T lymphoma in chicken. GaHV-2 encodes a basic leucine zipper (bZIP) protein of the AP-1 family, Meq. Upon formation of homo- or heterodimers with c-Jun, Meq may modulate the expres

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e6ebd063bd75080f78befd2889fa0b2
https://doi.org/10.1128/jvi.02449-12

mdv1-miR-M7-5p, located in the newly identified first intron of the latency-associated transcript of Marek’s disease virus, targets the immediate-early genes ICP4 and ICP27

Autor: Denis Rasschaert, S. Strassheim, Gregoire Stik, S. Laurent

Publikováno v: Journal of General Virology
Journal of General Virology, Microbiology Society, 2012, 93, pp.1731-1742. ⟨10.1099/vir.0.043109-0⟩

Marek’s disease virus serotype 1 (MDV-1) is an oncogenic alphaherpesvirus causing fatal T-cell lymphoma in chickens. MDV latency is characterized by the production of latency-associated transcripts (LATs), a family of non-protein-coding spliced RNA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d30acd418698576722539d8b6ecb480
https://doi.org/10.1099/vir.0.043109-0