Zobrazeno 1 - 10
of 128
pro vyhledávání: '"Denis Pompon"'
Autor:
Philippe Urban, Denis Pompon
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Conformational dynamics plays a critical role for the function of multidomain electron transfer complexes. While crystallographic or NMR approaches allow detailed insight into structures, lower resolution methods like cryo-electron microscop
Externí odkaz:
https://doaj.org/article/b97a4f31a5714b3bb1427fa757934d4f
Autor:
Francisco Esteves, Cristina M. M. Almeida, Sofia Silva, Inês Saldanha, Philippe Urban, José Rueff, Denis Pompon, Gilles Truan, Michel Kranendonk
Publikováno v:
Biomolecules, Vol 13, Iss 7, p 1083 (2023)
A unique cytochrome P450 (CYP) oxidoreductase (CPR) sustains activities of human microsomal CYPs. Its function requires toggling between a closed conformation enabling electron transfers from NADPH to FAD and then FMN cofactors and open conformations
Externí odkaz:
https://doaj.org/article/f62d15d3be7b4883af44a3ed7f77817f
Autor:
Luis F Garcia-Alles, Eric Lesniewska, Katharina Root, Nathalie Aubry, Nicolas Pocholle, Carlos I Mendoza, Eric Bourillot, Konstantin Barylyuk, Denis Pompon, Renato Zenobi, David Reguera, Gilles Truan
Publikováno v:
PLoS ONE, Vol 12, Iss 9, p e0185109 (2017)
CcmK proteins are major constituents of icosahedral shells of β-carboxysomes, a bacterial microcompartment that plays a key role for CO2 fixation in nature. Supported by the characterization of bidimensional (2D) layers of packed CcmK hexamers in cr
Externí odkaz:
https://doaj.org/article/0ae714a144604763ae6252bdd98ea651
Publikováno v:
International Journal of Molecular Sciences, Vol 19, Iss 6, p 1617 (2018)
Quantitative structure-activity relationships may bring invaluable information on structural elements of both enzymes and substrates that, together, govern substrate specificity. Buried active sites in cytochrome P450 enzymes are connected to the sol
Externí odkaz:
https://doaj.org/article/00245c6d415a487c88643e3d8bf97686
Autor:
Maï Panchal, Jacqueline Loeper, Jack-Christophe Cossec, Claire Perruchini, Adina Lazar, Denis Pompon, Charles Duyckaerts
Publikováno v:
Journal of Lipid Research, Vol 51, Iss 3, Pp 598-605 (2010)
Extensive knowledge of the protein components of the senile plaques, one of the hallmark lesions of Alzheimer’s disease, has been acquired over the years, but their lipid composition remains poorly known. Evidence suggests that cholesterol contribu
Externí odkaz:
https://doaj.org/article/ffa2e09e036e47a39b276772929131a6
Publikováno v:
BioTechniques, Vol 45, Iss 5, Pp 523-532 (2008)
Combinatorial libraries coding for mosaic enzymes with predefined crossover points constitute useful tools to address and model structure-function relationships and for functional optimization of enzymes based on multivariate statistics. The presente
Externí odkaz:
https://doaj.org/article/aed950851d0e41baacf2eef4ed14f055
Publikováno v:
BioTechniques, Vol 34, Iss 6, Pp 1280-1286 (2003)
Here we describe a computational approach for the high-throughput sequence mapping of combinatorial libraries obtained by DNA shuffling. Original algorithms and their software implementation were developed for the automated and reliable analysis of h
Externí odkaz:
https://doaj.org/article/5c8fcb83890a47c9b0fe1569d2270d8f
Autor:
Kranendonk, Francisco Esteves, Cristina M. M. Almeida, Sofia Silva, Inês Saldanha, Philippe Urban, José Rueff, Denis Pompon, Gilles Truan, Michel
Publikováno v:
Biomolecules; Volume 13; Issue 7; Pages: 1083
A unique cytochrome P450 (CYP) oxidoreductase (CPR) sustains activities of human microsomal CYPs. Its function requires toggling between a closed conformation enabling electron transfers from NADPH to FAD and then FMN cofactors and open conformations
Publikováno v:
Biochimica et Biophysica Acta (BBA) - General Subjects. 1867:130343
Autor:
Philippe Urban, Denis POMPON
Large range structural dynamics plays a critical role for the function of electron transfer proteins. This information is generally not available from crystallographic structures, while cryo-electron microscopy (cryo-EM) can provide some elements but
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a892bed0997bc77ad48858904b467342
https://doi.org/10.1101/2022.03.21.485149
https://doi.org/10.1101/2022.03.21.485149