Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Denis Paul Harkin"'
Autor:
Paul Wallace Medlow, Christopher James Steele, Andrena Marie McCavigan, Wesley Reardon, Christopher Michael Brown, Shauna May Lambe, Felipe Augusto Andre Ishiy, Steven Michael Walker, Gemma Elizabeth Logan, Olaide Yaqeen Raji, Viktor Berge, Betina Katz, Elaine Williamson Kay, Katherine Sheehan, Ronald William Watson, Denis Paul Harkin, Richard Darragh Kennedy, Laura Anne Knight
Publikováno v:
BMC Medical Genomics, Vol 11, Iss 1, Pp 1-11 (2018)
Abstract Background There is a clear need for assays that can predict the risk of metastatic prostate cancer following curative procedures. Importantly these assays must be analytically robust in order to provide quality data for important clinical d
Externí odkaz:
https://doaj.org/article/cea50b98202e4eea84680d0f7edc20bd
Autor:
Christopher Steele, Peggy L. Porter, William E. Barlow, Gabriel N. Hortobagyi, Debu Tripathy, Kamilla Isakova, Daniel F. Hayes, Sunil Badve, Alastair M. Thompson, Laura A. Knight, Yesim Gökmen-Polar, Andrew K. Godwin, Eileen Parkes, Lajos Pusztai, Hannah M. Linden, Richard D. Kennedy, Shauna Lambe, Priyanka Sharma, Gemma E Logan, Steven Walker, Denis Paul Harkin, Harsh B. Pathak
Publikováno v:
J Clin Oncol
PURPOSE To independently validate two biomarkers, a 44-gene DNA damage immune response (DDIR) signature and stromal tumor-infiltrating lymphocytes (sTILs), as prognostic markers in patients with triple-negative breast cancer (TNBC) treated with adjuv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d85ba49c05aae7324331b8814628f25a
https://doi.org/10.1200/jco.19.00693
https://doi.org/10.1200/jco.19.00693
Autor:
Denis Paul Harkin, James R. Bradford, Sinead Donegan, Jayna Mistry, Hui Sun Leong, Richard D. Kennedy, Laura A. Knight, Steven Walker, Nuala McCabe, Karen Keating, Emma O'Connor
Publikováno v:
Cancer Research. 81:152-152
Tumor mutational burden (TMB) is emerging as a promising predictive biomarker to select cancer patients who will benefit from immunotherapy. However, accurate TMB estimation from sequencing data remains hampered by the ability to correctly distinguis
Autor:
Richard D. Kennedy, Kienan Savage, Richard D A Wilkinson, Katrina M. Lappin, Stuart McIntosh, Roger A. Greenberg, Eileen Parkes, Eliana M. Barros, David Johnston, Nuala McCabe, Denis Paul Harkin, Rayhaan M.M. Ali
Tumours with genomic instability demonstrate enhanced immunogenicity and potential for response to immune checkpoint blockade (ICB). We previously demonstrated activation of the cGAS-STING pathway following loss of DNA repair, resulting in cytokine i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::068685f1474980ce5318286b0872d3e1
https://doi.org/10.1101/764662
https://doi.org/10.1101/764662
Autor:
Viktor Berge, Olaide Raji, R.W. Watson, Katherine M. Sheehan, Denis Paul Harkin, Wesley Reardon, Christopher Steele, Felipe Augusto Andre Ishiy, Elaine W. Kay, Andrena McCavigan, Steven Walker, Laura A. Knight, Christopher Michael Brown, Shauna Lambe, Paul Wallace Medlow, Richard D. Kennedy, Betina Katz, Gemma E Logan
Publikováno v:
BMC Medical Genomics
Medlow, P W, Steele, C J, McCavigan, A M, Reardon, W, Brown, C M, Lambe, S M, Ishiy, F A A, Walker, S M, Logan, G E, Raji, O Y, Berge, V, Katz, B, Kay, E W, Sheehan, K, Watson, R W, Harkin, D P, Kennedy, R D & Knight, L A 2018, ' Analytical validation of a prognostic prostate cancer gene expression assay using formalin fixed paraffin embedded tissue ', BMC Medical Genomics, vol. 11, no. 1, 125 . https://doi.org/10.1186/s12920-018-0442-y
BMC Medical Genomics, Vol 11, Iss 1, Pp 1-11 (2018)
Medlow, P W, Steele, C J, McCavigan, A M, Reardon, W, Brown, C M, Lambe, S M, Ishiy, F A A, Walker, S M, Logan, G E, Raji, O Y, Berge, V, Katz, B, Kay, E W, Sheehan, K, Watson, R W, Harkin, D P, Kennedy, R D & Knight, L A 2018, ' Analytical validation of a prognostic prostate cancer gene expression assay using formalin fixed paraffin embedded tissue ', BMC Medical Genomics, vol. 11, no. 1, 125 . https://doi.org/10.1186/s12920-018-0442-y
BMC Medical Genomics, Vol 11, Iss 1, Pp 1-11 (2018)
Background There is a clear need for assays that can predict the risk of metastatic prostate cancer following curative procedures. Importantly these assays must be analytically robust in order to provide quality data for important clinical decisions.
Autor:
Margaret Grayson, Anna Gavin, Tracy Robson, Jacqueline James, Manuel Salto-Tellez, Kevin M. Prise, Robert D. Ladner, Liam J. Murray, David Waugh, Peter W. Hamilton, Patrick G. Johnston, Richard D. Kennedy, Darragh G. McArt, Ruth Boyd, Richard H. Wilson, Sandra Van Schaeybroeck, Tim Harrison, Mark Lawler, Joe M. O'Sullivan, Denis Paul Harkin
Publikováno v:
Cancer. 122:664-673
The last 20 years have seen significant advances in cancer care in Northern Ireland, leading to measureable improvements in patient outcomes. Crucial to this transformation has been an ethos that recognizes the primacy role of research in effecting h
Autor:
Richard D. Kennedy, Ciara Lyons, Christopher Steele, Darren M. Mitchell, Brendan Pang, Sean O. Hynes, Stephen McQuaid, D.A. Loblaw, Kevin M. Prise, Denis Paul Harkin, Darragh G. McArt, Viktor Berge, Suneil Jain, David Waugh, Betina Katz, Jacqueline James, Joe M. O'Sullivan, Laura A. Knight, Andrena McCavigan, Declan O'Rourke, Steven Walker, Paul Wallace Medlow, Simon S. McDade, Gemma E Logan, Ian G. Mills
Publikováno v:
Annals of Oncology
Jain, S, Lyons, C A, Walker, S M, McQuaid, S, Hynes, S, Mitchell, D, Pang, B, Logan, G E, McCavigan, A M, O'Rourke, D, McArt, D, McDade, S, Mills, I, Prise, K M, Knight, L A, Steele, C J, Medlow, P W, Berge, V, Katz, B, Loblaw, D A, Harkin, D P, James, J, O'Sullivan, J M, Kennedy, R D & Waugh, D J 2017, ' Validation of a Metastatic Assay using biopsies to improve risk stratification in patients with prostate cancer treated with radical radiation therapy ' Annals of Oncology . DOI: 10.1093/annonc/mdx637
Jain, S, Lyons, C A, Walker, S M, McQuaid, S, Hynes, S, Mitchell, D, Pang, B, Logan, G E, McCavigan, A M, O'Rourke, D, McArt, D, McDade, S, Mills, I, Prise, K M, Knight, L A, Steele, C J, Medlow, P W, Berge, V, Katz, B, Loblaw, D A, Harkin, D P, James, J, O'Sullivan, J M, Kennedy, R D & Waugh, D J 2017, ' Validation of a Metastatic Assay using biopsies to improve risk stratification in patients with prostate cancer treated with radical radiation therapy ' Annals of Oncology . DOI: 10.1093/annonc/mdx637
Background Radiotherapy is an effective treatment of intermediate/high-risk locally advanced prostate cancer, however,>30% of patients relapse within 5 years. Clinicopathological parameters currently fail to identify patients prone to systemic relaps
Autor:
Eileen Parkes, Andrena McCavigan, Laura A. Knight, Richard D. Kennedy, Denis Paul Harkin, Emma Reilly, Nuala McCabe, Steven Walker
Publikováno v:
Cancer Research. 78:283-283
Background Recent studies have demonstrated limited success of immune checkpoint therapies in unselected prostate cancer. We therefore assessed an immune based DNA Damage Repair Deficiency (DDRD) assay, that we have previously reported represents act
Autor:
Naomi Dickson, Caolan Harkin, Laura A. Knight, Reinhold J. Medina, Aya El Helali, Caroline O. Michie, Jacqueline James, Lara Dura Perez, Stephen McQuaid, Christopher Steele, Alan W. Stitt, Nuala McCabe, Richard H. Wilson, Christina L. O'Neill, Niamh McGivern, Richard D. Kennedy, Denis Paul Harkin, Andrena McCavigan, W. Glenn McCluggage, Charlie Gourley
Publikováno v:
Cancer Research. 78:7-7
Introduction: 40-45% of patients with High Grade Serous Ovarian Cancer (HGSOC) will eventually relapse with platinum resistant disease. Tothill et al and TCGA are two independent gene expression datasets which have demonstrated the presence of a mese
Autor:
Alan W. Stitt, Laura A. Knight, Charlie Gourley, Richard D. Kennedy, Lara Dura Perez, Christopher Steele, Reinhold J. Medina, W. Glenn McCluggage, Richard H. Wilson, Aya El-Helali, Caroline O. Michie, Christina L. O'Neill, Stephen McQuaid, Andrena McCavigan, Nuala McCabe, Denis Paul Harkin, Jacqueline James
Publikováno v:
Journal of Clinical Oncology. 36:5578-5578
5578Background: Patients with High Grade Serous Ovarian Cancer (HGSOC) initially respond to SOC platinum based treatment but most will eventually relapse with platinum resistant disease. Angiogenes...