Analytical validation of a prognostic prostate cancer gene expression assay using formalin fixed paraffin embedded tissue

Autor: Paul Wallace Medlow, Christopher James Steele, Andrena Marie McCavigan, Wesley Reardon, Christopher Michael Brown, Shauna May Lambe, Felipe Augusto Andre Ishiy, Steven Michael Walker, Gemma Elizabeth Logan, Olaide Yaqeen Raji, Viktor Berge, Betina Katz, Elaine Williamson Kay, Katherine Sheehan, Ronald William Watson, Denis Paul Harkin, Richard Darragh Kennedy, Laura Anne Knight

Publikováno v: BMC Medical Genomics, Vol 11, Iss 1, Pp 1-11 (2018)

Abstract Background There is a clear need for assays that can predict the risk of metastatic prostate cancer following curative procedures. Importantly these assays must be analytically robust in order to provide quality data for important clinical d

Externí odkaz: https://doaj.org/article/cea50b98202e4eea84680d0f7edc20bd

Abstract 152: A machine learning approach to detect FFPE artefacts leads to accurate estimation of tumor mutational burden from sequencing data without a matched normal

Autor: Denis Paul Harkin, James R. Bradford, Sinead Donegan, Jayna Mistry, Hui Sun Leong, Richard D. Kennedy, Laura A. Knight, Steven Walker, Nuala McCabe, Karen Keating, Emma O'Connor

Publikováno v: Cancer Research. 81:152-152

Tumor mutational burden (TMB) is emerging as a promising predictive biomarker to select cancer patients who will benefit from immunotherapy. However, accurate TMB estimation from sequencing data remains hampered by the ability to correctly distinguis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::715182d5944ece7e04ddf1053d24c257
https://doi.org/10.1158/1538-7445.am2021-152

Analytical validation of a prognostic prostate cancer gene expression assay using formalin fixed paraffin embedded tissue

Autor: Viktor Berge, Olaide Raji, R.W. Watson, Katherine M. Sheehan, Denis Paul Harkin, Wesley Reardon, Christopher Steele, Felipe Augusto Andre Ishiy, Elaine W. Kay, Andrena McCavigan, Steven Walker, Laura A. Knight, Christopher Michael Brown, Shauna Lambe, Paul Wallace Medlow, Richard D. Kennedy, Betina Katz, Gemma E Logan

Publikováno v: BMC Medical Genomics
Medlow, P W, Steele, C J, McCavigan, A M, Reardon, W, Brown, C M, Lambe, S M, Ishiy, F A A, Walker, S M, Logan, G E, Raji, O Y, Berge, V, Katz, B, Kay, E W, Sheehan, K, Watson, R W, Harkin, D P, Kennedy, R D & Knight, L A 2018, ' Analytical validation of a prognostic prostate cancer gene expression assay using formalin fixed paraffin embedded tissue ', BMC Medical Genomics, vol. 11, no. 1, 125 . https://doi.org/10.1186/s12920-018-0442-y
BMC Medical Genomics, Vol 11, Iss 1, Pp 1-11 (2018)

Background There is a clear need for assays that can predict the risk of metastatic prostate cancer following curative procedures. Importantly these assays must be analytically robust in order to provide quality data for important clinical decisions.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c925aeaf48d126ad84c500715bbe091
https://doi.org/10.1186/s12920-018-0442-y

Validation of a Metastatic Assay using biopsies to improve risk stratification in patients with prostate cancer treated with radical radiation therapy

Autor: Richard D. Kennedy, Ciara Lyons, Christopher Steele, Darren M. Mitchell, Brendan Pang, Sean O. Hynes, Stephen McQuaid, D.A. Loblaw, Kevin M. Prise, Denis Paul Harkin, Darragh G. McArt, Viktor Berge, Suneil Jain, David Waugh, Betina Katz, Jacqueline James, Joe M. O'Sullivan, Laura A. Knight, Andrena McCavigan, Declan O'Rourke, Steven Walker, Paul Wallace Medlow, Simon S. McDade, Gemma E Logan, Ian G. Mills

Publikováno v: Annals of Oncology
Jain, S, Lyons, C A, Walker, S M, McQuaid, S, Hynes, S, Mitchell, D, Pang, B, Logan, G E, McCavigan, A M, O'Rourke, D, McArt, D, McDade, S, Mills, I, Prise, K M, Knight, L A, Steele, C J, Medlow, P W, Berge, V, Katz, B, Loblaw, D A, Harkin, D P, James, J, O'Sullivan, J M, Kennedy, R D & Waugh, D J 2017, ' Validation of a Metastatic Assay using biopsies to improve risk stratification in patients with prostate cancer treated with radical radiation therapy ' Annals of Oncology . DOI: 10.1093/annonc/mdx637

Background Radiotherapy is an effective treatment of intermediate/high-risk locally advanced prostate cancer, however,>30% of patients relapse within 5 years. Clinicopathological parameters currently fail to identify patients prone to systemic relaps

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1e6c8ec3437350e57327302da86183a
http://ora.ox.ac.uk/objects/uuid:

Abstract 7: Platinum resistance in epithelial ovarian cancer is dependent on a PDGFR alpha-VEGF-A signalling mechanism that activates downstream angiogenesis pathways

Autor: Naomi Dickson, Caolan Harkin, Laura A. Knight, Reinhold J. Medina, Aya El Helali, Caroline O. Michie, Jacqueline James, Lara Dura Perez, Stephen McQuaid, Christopher Steele, Alan W. Stitt, Nuala McCabe, Richard H. Wilson, Christina L. O'Neill, Niamh McGivern, Richard D. Kennedy, Denis Paul Harkin, Andrena McCavigan, W. Glenn McCluggage, Charlie Gourley

Publikováno v: Cancer Research. 78:7-7

Introduction: 40-45% of patients with High Grade Serous Ovarian Cancer (HGSOC) will eventually relapse with platinum resistant disease. Tothill et al and TCGA are two independent gene expression datasets which have demonstrated the presence of a mese

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::abc5960a1c08a52e5f39fefc08751a85
https://doi.org/10.1158/1538-7445.am2018-7