Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Denis Normandin"'
Autor:
M. David Percival, Denis Normandin, Karen Ortega, Joel Rubin, Nathalie Méthot, Diane Ethier, T. Jagadeeswar Reddy, Denis Riendeau, Simon Wong, Daniel Guay, Christian Beaulieu
Publikováno v:
Molecular Pharmacology. 73:1857-1865
Inhibition of cathepsin C, a dipeptidyl peptidase that activates many serine proteases, represents an attractive therapeutic strategy for inflammatory diseases with a high neutrophil burden. We recently showed the feasibility of blocking the activati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43b3d96663c517f65c9a67131bfbfe1f
https://doi.org/10.1124/mol.108.045682
https://doi.org/10.1124/mol.108.045682
Autor:
Jacquelin Jolette, Nancy Kelly, Kathleen Deschamps, Christopher M. Tan, Denis Normandin, Carole Desroches, Cindy Jones
Publikováno v:
Journal of Histotechnology. 32:169-171
Eosinophils and mast cells are important cell types in human allergic inflammation and in various animal models of pulmonary inflammatory disease. Standard histology stains for these cell types in lungs and airways include the toluidine blue and the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::df5a9ef31ab5697116d4bc0af125c86e
https://doi.org/10.1179/his.2009.32.4.169
https://doi.org/10.1179/his.2009.32.4.169
Autor:
Ailsa Lee Loy, Susan Collins, Chi-Chung Chan, Paul Payette, Brian P. Kennedy, Mounib Elchebly, Denis Normandin, Jean Himms-Hagen, Alan Cheng, Eva Michaliszyn, Michel L. Tremblay, Michael J. Gresser, Chidambaram Ramachandran, Wanda Cromlish
Publikováno v:
Science. 283:1544-1548
Protein tyrosine phosphatase–1B (PTP-1B) has been implicated in the negative regulation of insulin signaling. Disruption of the mouse homolog of the gene encoding PTP-1B yielded healthy mice that, in the fed state, had blood glucose concentrations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65dec93f24ba3e32ae498fd95e756bbf
https://doi.org/10.1126/science.283.5407.1544
https://doi.org/10.1126/science.283.5407.1544
Autor:
Renata M. Oballa, Liette Belair, W. Cameron Black, Kelly Bleasby, Chi Chung Chan, Carole Desroches, Xiaobing Du, Robert Gordon, Jocelyne Guay, Sebastien Guiral, Michael J. Hafey, Emelie Hamelin, Zheng Huang, Brian Kennedy, Nicolas Lachance, France Landry, Chun Sing Li, Joseph Mancini, Denis Normandin, Alessandro Pocai, David A. Powell, Yeeman K. Ramtohul, Kathryn Skorey, Dan Sørensen, Wayne Sturkenboom, Angela Styhler, Deena M. Waddleton, Hao Wang, Simon Wong, Lijing Xu, Lei Zhang
Publikováno v:
Journal of medicinal chemistry. 54(14)
The potential use of SCD inhibitors for the chronic treatment of diabetes and dyslipidemia has been limited by preclinical adverse events associated with inhibition of SCD in skin and eye tissues. To establish a therapeutic window, we embarked on des
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1c43863779b7e91be0da9e7afe20903
https://pubmed.ncbi.nlm.nih.gov/21661758
https://pubmed.ncbi.nlm.nih.gov/21661758
Autor:
Douglas J. Pon, Eric S. Muise, Kathleen M. Metters, François Nantel, Annette Robichaud, Denis Normandin, Sonia Lamontagne, Louise Boulet, Pauline Luk, George S. Robertson, Emily Meadows
Publikováno v:
Brain research. 920(1-2)
Pre-clinical and clinical studies are currently underway to evaluate the potential of phosphodiesterase-4 (PDE4) inhibitors for the treatment of chronic obstructive pulmonary disease and other inflammatory conditions of the airways. The most common s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::437163ce6475aa6497ed8d9d83a16be7
https://pubmed.ncbi.nlm.nih.gov/11716814
https://pubmed.ncbi.nlm.nih.gov/11716814
Autor:
Simon Wong, Kathleen M. Metters, Gary P. O'Neill, Maria Cirino, Richard M. Breyer, P. Masson, François Nantel, Denis Normandin, Danielle Denis
Publikováno v:
Advances in Prostaglandin and Leukotriene Research ISBN: 9789048158812
Small clinical studies of asthma [1–5] found that inhaled prostaglandin E2 (PGE2) induced bronchodilation and reduced the influx of inflammatory cells in the airways. PGE2 activates four receptors identified as EP1–4 [6,7]. The activation of two
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::995563b58504173bfb1b3d812ca53768
https://doi.org/10.1007/978-94-015-9721-0_18
https://doi.org/10.1007/978-94-015-9721-0_18
