Phenotype of POLE-mutated endometrial cancer.

Autor: Sara Imboden, Denis Nastic, Mehran Ghaderi, Filippa Rydberg, Tilman T Rau, Michael D Mueller, Elisabeth Epstein, Joseph W Carlson

Publikováno v: PLoS ONE, Vol 14, Iss 3, p e0214318 (2019)

Background and purposeIndividualized therapy in endometrial cancer, the most common gynaecologic cancer in the developed world, focuses on identifying specific molecular subtypes. Mutations in the exonuclease domain of the DNA polymerase epsilon (POL

Externí odkaz: https://doaj.org/article/c32f2ad8fb5c459cb66ef925df6c9f18

An Unusual Case of Bleeding in Small Intestine

Autor: Martin Måhl, Miroslav Vujasinovic, Denis Nastic, Carmen Mesas Burgos, Ervin Toth, Cecilia K Zetterström, Gabriele Wurm Johansson

Publikováno v: Turk J Gastroenterol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9777a4ae3265111300fbbabe18034d9
https://pubmed.ncbi.nlm.nih.gov/34464325

Implementation of the 2021 molecular ESGO/ESTRO/ESP risk groups in endometrial cancer

Autor: Joseph W. Carlson, Filippa Rydberg, Sara Imboden, Michael D. Mueller, Denis Nastic, Mehran Ghaderi, Tilman T. Rau, Franziska Siegenthaler, Elisabeth Epstein

Publikováno v: Imboden, Sara; Nastic, Denis; Ghaderi, Mehran; Rydberg, Filippa; Siegenthaler, Franziska; Mueller, Michael D.; Rau, Tilman T.; Epstein, Elisabeth; Carlson, Joseph W. (2021). Implementation of the 2021 molecular ESGO/ESTRO/ESP risk groups in endometrial cancer. Gynecologic oncology, 162(2), pp. 394-400. Elsevier 10.1016/j.ygyno.2021.05.026

IntroductionIn 2021, a joint ESGO/ESTRO/ESP committee updated their evidence-based guidelines for endometrial cancer, recommending a new risk grouping incorporating both clinicopathologic and molecular parameters. We applied the new risk grouping and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2665143fbb93511d68a41e4cbd04b512
https://doi.org/10.1101/2021.03.25.21254244

A Selective Biomarker Panel Increases the Reproducibility and the Accuracy in Endometrial Biopsy Diagnosis

Autor: Marianne Lidang, Anna Måsbäck, Anne Britt Abusland, Olli Carpén, Julia Bak, Elisa Lappi-Blanco, Keng-Ling Wallin, Denis Nastic, Anni Grove, Bjørn I. Bertelsen, Joseph W. Carlson, Claudia Mateoiu, Annikki Liakka, Emma Shanwell, Jonas Selling, Ben Davidson, Marit Valla

Publikováno v: Nastic, D, Shanwell, E, Wallin, K-L, Valla, M, Måsbäck, A, Mateoiu, C, Lidang, M, Liakka, A, Lappi-Blanco, E, Grove, A, Davidson, B, Carpen, O, Bertelsen, B I, Bak, J, Abusland, A B, Selling, J & Carlson, J W 2017, ' A Selective Biomarker Panel Increases the Reproducibility and the Accuracy in Endometrial Biopsy Diagnosis ', International Journal of Gynecological Pathology, vol. 36, no. 4, pp. 339-347 . https://doi.org/10.1097/PGP.0000000000000334

Grading and histologic typing of endometrial cancer in biopsy material has a direct impact on the decision to perform lymphadenectomy and/or omentectomy in many cancer centers. Endometrial biopsies are among the most common general surgical pathology

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3afff6b43bac85fb01f5e1f89d8b66a7
https://doi.org/10.1097/PGP.0000000000000334

Abstract 465: Molecular classification of endometrial cancer provides complementary information but does not outperform current predictive models: The Karolinska and Bern experience

Autor: Denis Nastic, Sara Imboden, Mehran Ghaderi, Filippa Rydberg, Daniel Olsson, Michael Mueller, Tilman T. Rau, Elisabeth Epstein, Joseph Carlson

Publikováno v: Cancer Research. 79:465-465

Purpose: The purpose of this study was to evaluate the performance of a proposed prognostic molecular classification of endometrial cancer in a retrospective cohort of n=604 patients. A secondary goal was to compare the performance to existing progno

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2044defac16626b639d5d8d6a48cb800
https://doi.org/10.1158/1538-7445.am2019-465