Zobrazeno 1 - 10
of 125
pro vyhledávání: '"Denis Lee"'
Autor:
Mary C. Bedard, Tafadzwa Chihanga, Adrean Carlile, Robert Jackson, Marion G. Brusadelli, Denis Lee, Andrew VonHandorf, Mark Rochman, Phillip J. Dexheimer, Jeffrey Chalmers, Gerard Nuovo, Maria Lehn, David E. J. Williams, Aditi Kulkarni, Molly Carey, Amanda Jackson, Caroline Billingsley, Alice Tang, Chad Zender, Yash Patil, Trisha M. Wise-Draper, Thomas J. Herzog, Robert L. Ferris, Ady Kendler, Bruce J. Aronow, Matthew Kofron, Marc E. Rothenberg, Matthew T. Weirauch, Koenraad Van Doorslaer, Kathryn A. Wikenheiser-Brokamp, Paul F. Lambert, Mike Adam, S. Steven Potter, Susanne I. Wells
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
The role of keratinocyte subpopulations in the different phases of the viral cycle during HPV16 infection remains to be characterised. Here, single cell RNA sequencing of HPV16 infected and uninfected organoids identifies 12 distinct keratinocyte pop
Externí odkaz:
https://doaj.org/article/944133d8df914bc3ab573aab9d9f4d14
Autor:
James C Romero-Masters, Miranda Grace, Denis Lee, Joshua Lei, Melanie DePamphilis, Darya Buehler, Rong Hu, Ella Ward-Shaw, Simon Blaine-Sauer, Nathalie Lavoie, Elizabeth A White, Karl Munger, Paul F Lambert
Publikováno v:
PLoS Pathogens, Vol 19, Iss 4, p e1011215 (2023)
Human papillomaviruses (HPVs) contribute to approximately 5% of all human cancers. Species-specific barriers limit the ability to study HPV pathogenesis in animal models. Murine papillomavirus (MmuPV1) provides a powerful tool to study the roles of p
Externí odkaz:
https://doaj.org/article/a3f357b0c51341d8ace6ff84e078a09e
Autor:
Deo R Singh, Scott E Nelson, Abigail S Pawelski, Juan A Cantres-Velez, Alisha S Kansra, Nicholas P Pauly, Jillian A Bristol, Mitchell Hayes, Makoto Ohashi, Alejandro Casco, Denis Lee, Stuart A Fogarty, Paul F Lambert, Eric C Johannsen, Shannon C Kenney
Publikováno v:
PLoS Pathogens, Vol 18, Iss 10, p e1010868 (2022)
Differentiated epithelial cells are an important source of infectious EBV virions in human saliva, and latent Epstein-Barr virus (EBV) infection is strongly associated with the epithelial cell tumor, nasopharyngeal carcinoma (NPC). However, it has be
Externí odkaz:
https://doaj.org/article/c603bab0a33b48b1a46a9dd7f2ea5c12
Autor:
Nicholas Van Sciver, Makoto Ohashi, Dhananjay M. Nawandar, Nicholas P. Pauly, Denis Lee, Kathleen R. Makielski, Jillian A. Bristol, Sai Wah Tsao, Paul F. Lambert, Eric C. Johannsen, Shannon C. Kenney
Publikováno v:
PLoS Pathogens, Vol 17, Iss 11 (2021)
Epstein-Barr virus (EBV) is a human herpesvirus that causes infectious mononucleosis and contributes to both B-cell and epithelial-cell malignancies. EBV-infected epithelial cell tumors, including nasopharyngeal carcinoma (NPC), are largely composed
Externí odkaz:
https://doaj.org/article/cf1e2f37626547988264e0a8c5e31e20
Autor:
Tao Wei, Miranda Grace, Aayushi Uberoi, James C. Romero-Masters, Denis Lee, Paul F. Lambert, Karl Munger
Publikováno v:
mBio, Vol 12, Iss 4 (2021)
ABSTRACT The species specificity of papillomaviruses has been a significant roadblock for performing in vivo pathogenesis studies in common model organisms. The Mus musculus papillomavirus type 1 (MmuPV1) causes cutaneous papillomas that can progress
Externí odkaz:
https://doaj.org/article/ef1292efa7fb4e6381ea52dd70d70fbe
Autor:
Tao Wei, Suyong Choi, Darya Buehler, Denis Lee, Ella Ward-Shaw, Richard A. Anderson, Paul F. Lambert
Publikováno v:
Cancers, Vol 13, Iss 9, p 2276 (2021)
Approximately 25% of head and neck squamous cell carcinomas (HNSCC) are associated with human papillomavirus (HPV) infection. In these cancers as well as in HPV-associated anogenital cancers, PI3K signaling is highly activated. We previously showed t
Externí odkaz:
https://doaj.org/article/f8c3d6a4b40e4b36b0821812c9a93abb
Autor:
Mary C. Bedard, Marion G. Brusadelli, Adrean Carlile, Sonya Ruiz-Torres, Hannah Lodin, Denis Lee, Matthew Kofron, Paul F. Lambert, Adam Lane, Najim Ameziane, El Mustapha Bahassi, Kathryn A. Wikenheiser-Brokamp, Alessandro de Alarcon, David F. Smith, Susanne I. Wells
Publikováno v:
Viruses, Vol 13, Iss 1, p 68 (2021)
Juvenile-onset recurrent respiratory papillomatosis (JoRRP) is driven by human papillomavirus (HPV) low-risk strains and is associated with significant morbidity. While previous studies of 2D cultures have shed light on disease pathogenesis and demon
Externí odkaz:
https://doaj.org/article/bb26671686ec46b4893dd0fd5e7dd53e
Autor:
Louis Cicchini, Joseph A. Westrich, Tao Xu, Daniel W. Vermeer, Jennifer N. Berger, Eric T. Clambey, Denis Lee, John I. Song, Paul F. Lambert, Robert O. Greer, John H. Lee, Dohun Pyeon
Publikováno v:
mBio, Vol 7, Iss 3 (2016)
ABSTRACT High-risk human papillomaviruses (HPVs) are causally associated with multiple human cancers. Previous studies have shown that the HPV oncoprotein E7 induces immune suppression; however, the underlying mechanisms remain unknown. To understand
Externí odkaz:
https://doaj.org/article/968814f4f50343f0bc8be64a70db166d
Autor:
Dhananjay M Nawandar, Anqi Wang, Kathleen Makielski, Denis Lee, Shidong Ma, Elizabeth Barlow, Jessica Reusch, Ru Jiang, Coral K Wille, Deborah Greenspan, John S Greenspan, Janet E Mertz, Lindsey Hutt-Fletcher, Eric C Johannsen, Paul F Lambert, Shannon C Kenney
Publikováno v:
PLoS Pathogens, Vol 11, Iss 10, p e1005195 (2015)
Epstein-Barr virus (EBV) is a human herpesvirus associated with B-cell and epithelial cell malignancies. EBV lytically infects normal differentiated oral epithelial cells, where it causes a tongue lesion known as oral hairy leukoplakia (OHL) in immun
Externí odkaz:
https://doaj.org/article/17c699bb23124beb9484bc834e8a9693
Autor:
Valdimara C. Vieira, Brandon Leonard, Elizabeth A. White, Gabriel J. Starrett, Nuri A. Temiz, Laurel D. Lorenz, Denis Lee, Marcelo A. Soares, Paul F. Lambert, Peter M. Howley, Reuben S. Harris
Publikováno v:
mBio, Vol 5, Iss 6 (2014)
ABSTRACT Several recent studies have converged upon the innate immune DNA cytosine deaminase APOBEC3B (A3B) as a significant source of genomic uracil lesions and mutagenesis in multiple human cancers, including those of the breast, head/neck, cervix,
Externí odkaz:
https://doaj.org/article/78b02926d2814d79a2e5419970d5363e