Zobrazeno 1 - 10
of 290
pro vyhledávání: '"Denis Le Bihan"'
Autor:
Denis Le Bihan
Publikováno v:
Entropy, Vol 25, Iss 12, p 1645 (2023)
It has been shown that the theory of relativity can be applied physically to the functioning brain, so that the brain connectome should be considered as a four-dimensional spacetime entity curved by brain activity, just as gravity curves the four-dim
Externí odkaz:
https://doaj.org/article/abbb0a66815d431095fb1d370305a791
Autor:
Amandine Bery, Olivier Etienne, Laura Mouton, Sofiane Mokrani, Christine Granotier-Beckers, Laurent R. Gauthier, Justyne Feat-Vetel, Thierry Kortulewski, Elodie A. Pérès, Chantal Desmaze, Philippe Lestaveal, Vilma Barroca, Antony Laugeray, Fawzi Boumezbeur, Vincent Abramovski, Stéphane Mortaud, Arnaud Menuet, Denis Le Bihan, Jean-Pierre de Villartay, François D. Boussin
Publikováno v:
Cell Reports, Vol 42, Iss 4, Pp 112342- (2023)
Summary: XLF/Cernunnos is a component of the ligation complex used in classical non-homologous end-joining (cNHEJ), a major DNA double-strand break (DSB) repair pathway. We report neurodevelopmental delays and significant behavioral alterations assoc
Externí odkaz:
https://doaj.org/article/932eb1262b3c484399e5f2d802035f1e
Autor:
Mami Iima, Denis Le Bihan
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
Breast cancer is the leading cause of cancer in women with a huge medical, social and economic impact. Mammography (MMG) has been the gold standard method until now because it is relatively inexpensive and widely available. However, MMG suffers from
Externí odkaz:
https://doaj.org/article/cd047c34bb0c472d9115ea2efad7b294
Autor:
Yuko Someya, Mami Iima, Hirohiko Imai, Akihiko Yoshizawa, Masako Kataoka, Hiroyoshi Isoda, Denis Le Bihan, Yuji Nakamoto
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract We investigated the associations of time-dependent DWI, non-Gaussian DWI, and CEST parameters with histological biomarkers in a breast cancer xenograft model. 22 xenograft mice (7 MCF-7 and 15 MDA-MB-231) were scanned at 4 diffusion times [T
Externí odkaz:
https://doaj.org/article/c060bd3b543e4d35a17a33a41cfa631c
Autor:
Davide Boido, Ravi L. Rungta, Bruno-Félix Osmanski, Morgane Roche, Tomokazu Tsurugizawa, Denis Le Bihan, Luisa Ciobanu, Serge Charpak
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Neuronal activity leads to a local increase in blood flow and volume, a process termed hyperaemia. Here, the authors employ multiple imaging approaches of neuronal and vascular activity at varying resolution to delineate the spatiotemporal dynamics o
Externí odkaz:
https://doaj.org/article/caefeb2ed51248469672e890c4215216
Autor:
Yoshifumi Abe, Norio Takata, Yuki Sakai, Hiro Taiyo Hamada, Yuichi Hiraoka, Tomomi Aida, Kohichi Tanaka, Denis Le Bihan, Kenji Doya, Kenji F Tanaka
Publikováno v:
NeuroImage, Vol 223, Iss , Pp 117318- (2020)
Diffusion functional magnetic resonance imaging (DfMRI) has been proposed as an alternative functional imaging method to detect brain activity without confounding hemodynamic effects. Here, taking advantage of this DfMRI feature, we investigated abno
Externí odkaz:
https://doaj.org/article/5135297929c14ac1afedf94662dc7293
Autor:
Denis Le Bihan
Publikováno v:
Brain Multiphysics, Vol 1, Iss , Pp 100016- (2020)
Considering that the propagation speed of action potentials in the brain connectome has a finite limit and that present is ill-defined in the brain we apply concepts borrowed from the theories of special and general relativity to introduce the view t
Externí odkaz:
https://doaj.org/article/f09722d5a30a4425b5340d97447dd236
Publikováno v:
PLoS ONE, Vol 15, Iss 5, p e0229702 (2020)
The Glymphatic System (GS) has been proposed as a mechanism to clear brain tissue from waste. Its dysfunction might lead to several brain pathologies, including the Alzheimer's disease. A key component of the GS and brain tissue water circulation is
Externí odkaz:
https://doaj.org/article/06876edac7b74ee1b96c6d2569f3af7d
Autor:
Yuji Komaki, Clement Debacker, Boucif Djemai, Luisa Ciobanu, Tomokazu Tsurugizawa, Denis Le Bihan
Publikováno v:
PLoS ONE, Vol 15, Iss 5, p e0228759 (2020)
The contribution of astrocytes to the BOLD fMRI and DfMRI responses in visual cortex of mice following visual stimulation was investigated using TGN-020, an aquaporin 4 (AQP4) channel blocker, acting as an astrocyte function perturbator. Under TGN-02
Externí odkaz:
https://doaj.org/article/004a702459d94505ac86292911835a46
Autor:
Takashi Ota, Masatoshi Hori, Denis Le Bihan, Hideyuki Fukui, Hiromitsu Onishi, Atsushi Nakamoto, Takahiro Tsuboyama, Mitsuaki Tatsumi, Kazuya Ogawa, Noriyuki Tomiyama
Publikováno v:
Journal of Clinical Medicine, Vol 10, Iss 19, p 4553 (2021)
Background: Strong correlation has been reported between tissue water diffusivity and tissue elasticity in the liver. The purpose of this study is to explore the capability of diffusion–based virtual MR elastography (VMRE) in the characterization o
Externí odkaz:
https://doaj.org/article/9cecd8509e7c4a6b935a8dcc85a6b54e