Zobrazeno 1 - 10 of 30 pro vyhledávání: '"Denis L'Abbé"'
1
Akademický článek
Influence of variant-specific mutations, temperature and pH on conformations of a large set of SARS-CoV-2 spike trimer vaccine antigen candidates
Autor: Matthew Stuible, Joseph D. Schrag, Joey Sheff, Daria Zoubchenok, Simon Lord-Dufour, Brian Cass, Denis L’Abbé, Alex Pelletier, Martin A. Rossotti, Jamshid Tanha, Christian Gervais, Roger Maurice, Majida El Bakkouri, Mauro Acchione, Yves Durocher
Publikováno v: Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract SARS-CoV-2 subunit vaccines continue to be the focus of intense clinical development worldwide. Protein antigens in these vaccines most commonly consist of the spike ectodomain fused to a heterologous trimerization sequence, designed to mimi
Externí odkaz: https://doaj.org/article/dc399963cdec43a6ac763c16fa63044f
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2
Akademický článek
Unique epitope–antibody interactions in the intrinsically disordered proteoglycan-like domain of human carbonic anhydrase IX defined by high-resolution NMR combined with yeast surface display
Autor: Feng Ni, Cunle Wu, Ping Xu, Ping Wang, Yves Fortin, Melanie Arbour, Luke Masson, Denis L’Abbé, Andrea Acel, Mylene Gosselin, Anne E.G. Lenferink
Publikováno v: mAbs, Vol 15, Iss 1 (2023)
ABSTRACTCarbonic anhydrase (CA)-IX is an extracellular enzyme that is essential in the adaptation of tumor cells to their increasingly more hypoxic and acidic microenvironment. Within the family of carbonic anhydrases, CA-IX is unique in that it is t
Externí odkaz: https://doaj.org/article/bef68df9eb5940de9d22b6603ddf4189
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4
Akademický článek
Impact of the temperature on the interactions between common variants of the SARS-CoV-2 receptor binding domain and the human ACE2
Autor: Catherine Forest-Nault, Izel Koyuturk, Jimmy Gaudreault, Alex Pelletier, Denis L’Abbé, Brian Cass, Louis Bisson, Alina Burlacu, Laurence Delafosse, Matthew Stuible, Olivier Henry, Gregory De Crescenzo, Yves Durocher
Publikováno v: Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Several key mutations in the Spike protein receptor binding domain (RBD) have been identified to influence its affinity for the human Angiotensin-Converting Enzyme 2 (ACE2). Here, we perform a comparative study of the ACE2 binding to the wil
Externí odkaz: https://doaj.org/article/13bedb88d258407e8f1a229ff39ec266
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6
Akademický článek
Hydrogen-deuterium exchange mass spectrometry reveals three unique binding responses of mAbs directed to the catalytic domain of hCAIX
Autor: Joey G. Sheff, John F. Kelly, Anna Robotham, Traian Sulea, Félix Malenfant, Denis L’Abbé, Mélanie Duchesne, Alex Pelletier, Jean Lefebvre, Andrea Acel, Marie Parat, Mylene Gosselin, Cunle Wu, Yves Fortin, Jason Baardsnes, Henk Van Faassen, Shannon Awrey, Shawn C. Chafe, Paul C. McDonald, Shoukat Dedhar, Anne E.G. Lenferink
Publikováno v: mAbs, Vol 13, Iss 1 (2021)
Human carbonic anhydrase (hCAIX), an extracellular enzyme that catalyzes the reversible hydration of CO2, is often overexpressed in solid tumors. This enzyme is instrumental in maintaining the survival of cancer cells in a hypoxic and acidic tumor mi
Externí odkaz: https://doaj.org/article/05ceb9ddaa0e4ba48f2d8c3227f954cc
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7
Akademický článek
Foot-and-Mouth Disease: Optimization, Reproducibility, and Scalability of High-Yield Production of Virus-Like Particles for a Next-Generation Vaccine
Autor: Ana Clara Mignaqui, Alejandra Ferella, Brian Cass, Larissa Mukankurayija, Denis L'Abbé, Louis Bisson, Cintia Sánchez, Romina Scian, Sabrina Beatriz Cardillo, Yves Durocher, Andrés Wigdorovitz
Publikováno v: Frontiers in Veterinary Science, Vol 7 (2020)
Inactivated Foot-and-Mouth Disease (FMD) vaccine has proven to be effective in the control of the disease. However, its production has some disadvantages, including the costly biosafety facilities required for the production of huge amounts of growin
Externí odkaz: https://doaj.org/article/ab6893d8df71456386381a3cf749f5d2
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